赵伟 - 山东大学 - 基础医学院医学免疫学系

个人简介

受教育经历 2004/09—2007/06，第二军医大学，免疫学研究所暨医学免疫学国家重点实验室博士，导师：曹雪涛院士 2001/09—2004/06，第二军医大学，长海医院硕士，导师：赵宝珍教授 1996/09—2001/06，第二军医大学，海军临床医学系，本科/学士科研与学术工作经历 2013/09至今，山东大学，基础医学院医学免疫学系，教授(破格晋升) 2011/10—2013/08，山东大学，医学院医学免疫学研究所，讲师 2008/06—2011/09，山东大学，医学院医学免疫学研究所，博士后

研究领域

长期致力于病毒感染与固有免疫调控的研究工作，发现了多个参与抗病毒免疫反应调控的宿主因子并阐明了它们的作用机制。以病毒与宿主相互作用为切入点, 进一步揭示和丰富了抗病毒固有免疫信号通路调节网络；通过发现这些病毒宿主相互作用的关键节点分子，可为抗病毒药物研制提供新的潜在靶点。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Yu Z#, Song H, Jia M, Zhang J, Wang W, Li Q, Zhang L, Zhao W*. USP1-UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses. J.Exp.Med. 2017. 214(12): 3553-3563. Zhao C#, Jia M#, Song H, Yu Z, Wang W, Li Q, Zhang L, Zhao W*, Cao X*. The E3 ubiquitin ligase TRIM40 attenuates antiviral immune responses by targeting MDA5 and RIG-I. Cell. Rep. 2017. 21(6):1613-1623. Li S, Liang X, Ma L, Shen L, Li T, Zheng L, Sun A, Shang W, Chen C, Zhao W*, Jia J*. MiR-22 sustains NLRP3 expression and attenuates H. pylori-induced gastric carcinogenesis. Oncogene. 2018. 37(7):884-896. Huai W#, Song H#, Yu Z, Wang W, Han L, Sakamoto T, Seiki M, Zhang L, Zhang Q, Zhao W*. Mint3 potentiates TLR3/4- and RIG-I-induced IFN-β expression and antiviral immune responses. Proc Natl Acad Sci USA. 2016; 113(42):11925- 11930. Song H#, Liu B#, Huai W#, Yu Z, Wang W, Zhao J, Han L, Jiang G, Zhang L, Gao C*, Zhao W*. The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3. Nat.Commun. 2016; 7:13727. Huai W#, Zhao R#, Song H, Zhao J, Zhang L, Zhang L, Gao C, Han L*, Zhao W*. Aryl hydrocarbon receptor negatively regulates NLRP3 inflammasome activity by inhibiting NLRP3 transcription. Nat.Commun. 2014; 5:4738. Zhang M#, Wang L, Zhao X, Zhao K, Meng H, Zhao W*, Gao C*. TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1. J.Exp.Med. 2012; 209(10):1703-11. Song H#, Huai W, Yu Z, Wang W, Zhao J, Zhang L, Zhao W*. MLN4924, a first-in-class NEDD8-activating enzyme inhibitor, attenuates IFN-β production. J. Immunol. 2016; 196(7):3117-23. Huai W#, Song H, Wang L, Li B, Zhao J, Han L, Gao C, Jiang G, Zhang L, Zhao W*. Phosphatase PTPN4 preferentially inhibits TRIF-dependent TLR4 pathway by dephosphorylating TRAM. J. Immunol. 2015;194(9):4458-65. Wang L#, Zhang L#, Zhao X, Zhang M, Zhao W*, Gao C*. Lithium attenuates IFN-β production and antiviral response via inhibition of TANK-binding kinase 1 kinase activity. J. Immunol. 2013; 191(8):4392-4398. Zhao W#, Wang L, Zhang M, Yuan C, Gao C*. E3 Ubiquitin Ligase Tripartite motif 38 negatively regulates TLR-mediated immune responses by proteasomal degradation of TNF receptor-associated factor 6 inmacrophages. J. Immunol. 2012;188(6):2567-2574. Zhao W#, Wang L#, Zhang M#, Wang P, Yuan C, Qi J, Meng H, Gao C*. Tripartite motif-Containing protein 38 negatively regulates TLR3/4- and RIG-I–mediated IFN-β production and antiviral response by targeting NAP1. J. Immunol. 2012;188(11):5311-5318. Zhao W#, Wang L, Zhang M, Wang P, Qi J, Zhang L, Gao C*. Nuclear to cytoplasmic translocation of heterogeneous nuclear ribonucleoprotein U enhances TLR-induced pro-inflammatory cytokines production by stabilizing mRNAs in macrophages. J. Immunol. 2012;188(7):3179-3187. Zhao W#, Wang L#, Zhang M, Wang P, Zhang L, Yuan C, Qi J, Qiao Y, Kuo PC, Gao C*. NF-κB and AP-1 mediated DNA looping regulates osteopontin transcription in endotoxin-stimulated murine macrophages. J. Immunol. 2011;186(5):3173-3179. Zhao W#, Wang L, Zhang M, Wang P, Zhang L, Yuan C, Qi J, Qiao Y, Kuo PC, Gao C*. Peroxisome proliferator-activated receptor gamma negatively regulates IFN-beta production in TLR3 and TLR4-stimulated macrophages by preventing IRF3 binding to the IFN-beta promoter. J. Biol. Chem. 2011;286(7):5519-28. Zhao W*. Negative regulation of TBK1-mediated antiviral immunity. FEBS. Lett. 2013; 587(6):542-548. Zhao W#, Qi J#, Wang L, Zhang M, Wang P, Gao C*. LY294002 inhibits TLR3/4-mediated IFN-β production via inhibition of IRF3 activation with a PI3K-independent mechanism. FEBS. Lett. 2012;586(6):705-710. Hou X#, Wang L#, Zhang L, Pan X*, Zhao W*. Ubiquitin-specific protease 4 promotes TNF-α-induced apoptosis by deubiquitination of RIP1 inhead and neck squamous cell carcinoma. FEBS Lett. 2013;587(4):311-6.