个人简介
招生专业
085600-材料与化工
招生方向
微生物学,生物化学,酶
教育背景
2004-09--2007-12 山东大学 博士
2001-09--2004-08 山东大学 硕士
1997-09--2001-08 山东大学 学士
工作简历
2011-10~现在, 中国科学院天津工业生物技术研究所, 副研究员
2008-09~2011-09,国家毒理学研究中心(美国), 博士后
2004-09~2007-12,山东大学, 博士
2001-09~2004-08,山东大学, 硕士
1997-09~2001-08,山东大学, 学士
专利成果
( 1 ) 一株红平红球菌及其在原油脱硫中的应用 , 2007, 第 5 作者, 专利号: 200510044599.X
( 2 ) 一株基因重组的红平红球菌及其在脱除原油有害物-硫和氮中的应用, 2008, 第 5 作者, 专利号: 200610042259.8
( 3 ) 一株可耐受有机溶剂的恶臭假单胞菌及其在双液相反应中的应用, 2008, 第 5 作者, 专利号: 200610044410.1
( 4 ) 红平红球菌在清洗重油污垢中的应用, 2011, 第 2 作者, 专利号: 200810094048.8
科研项目
( 1 ) 全生物转化法从植物甾醇, 参与, 国家级, 2011-05--2017-04
( 2 ) 基因组进化育种-开发新一代甾体, 主持, 省级, 2011-10--2015-09
( 3 ) 甾体激素从头合成的人工细胞创建及应用, 参与, 国家级, 2020-01--2024-12
近期论文
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(1) Crystal structures and substrate recognition mechanism of 2, 3-dihydroxybenzoic acid decarboxylase from Fusarium oxysporum, ChemBioChem, 2020, 通讯作者
(2) Improving the catalytic efficiency and stereoselectivity of a nitrilase from Synechocystis sp. PCC6803 by semi-rational engineering en route to chiral γ-amino acids, Catalysis Science & Technology, 2019, 第 4 作者
(3) Flavin oxidoreductase-mediated regeneration of nicotinamide adenine dinucleotide with dioxygen and catalytic amount of flavin mononucleotide for one-pot multi-enzymatic preparation of ursodeoxycholic acid, Advanced Synthesis and Catalysis, 2019, 第 3 作者
(4) Improving and inverting Cβ‑stereoselectivity of threonine aldolase via substrate-binding-guided mutagenesis and a stepwise visual screening, ACS Catalysis, 2019, 第 3 作者
(5) Efficient Reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase, Nature Catalysis, 2019, 第 7 作者
(6) Efficient microbial synthesis of key steroidal intermediates from bio-renewable phytosterols by genetically modified Mycobacterium fortuitum strains, Green Chemistry, 2019, 第 2 作者
(7) Distinct regioselectivity of fungal P450 enzymes for steroidal hydroxylation, Applied and Environmental Microbiology, 2019, 通讯作者
(8) New product identification in the sterol metabolism by an industrial strain Mycobacterium neoaurum NRRL B-3805, Steroids, 2018, 通讯作者
(9) Molecular basis for the high activity and enantioselectivity of the carbonyl reductase from Sporobolomyces salmonicolor toward α-haloacetophenones, ACS Catalysis, 2018, 第 3 作者
(10) A fungal P450 enzyme from Thanatephorus cucumeris with steroid hydroxylation capabilities, Applied and Environmental Microbiology, 2018, 第 3 作者
(11) Characterization of new recombinant 3-ketosteroid -Δ1-dehydrogenases for the biotransformation of steroids, Applied Microbiology and Biotechnology, 2017, 第 2 作者
(12) 高效转化胆固醇菌株的筛选、鉴定及转化条件优化, Screening, identification and condition optimization of a bacterial strain efficient in biotransforming cholesterol, 应用与环境生物学报, 2014, 通讯作者
(13) Identification of the enzyme responsible for N-acetylation of norfloxacin by Microbacterium sp. Strin 4N2-2, Applied and Environmental Microbiology, 2013, 第 2 作者
(14) Probing the NADH- and Methyl Red-binding site of a FMN-dependent azoreductase (AzoA) from Enterococcus faecalis, Archives of Biochemistry and Biophysics, 2012, 第 1 作者
(15) Toxicological significance of azo dye metabolism by human intestinal microbiota, Frontiers in Bioscience, 2012, 第 1 作者
(16) Effects of Orange II and Sudan III azo dyes and their metabolites on Staphylococcus aureus, Journal of Industrial Microbiology Biotechnology, 2011, 第 2 作者
(17) Evidence for significantly enhancing reduction of azo dyes in Escherichia coli by expressed cytoplasmic azoreductase (AzoA) of Enterococcus faecalis, Protein and Peptide Lettters, 2010, 第 1 作者
(18) Identification and molecular characterization of a novel flavin-free NADPH preferred azoreductase encoded by azoB in Pigmentiphaga kullae K24, BMC Biochemistry, 2010, 第 2 作者