孙周通 - 中国科学院天津工业生物技术研究所 -

个人简介

教育背景 2005-09--2012-03 中国科学院上海生命科学研究院博士研究生 2003-09--2005-06 河南大学工学学士工作经历 2016-9～至今，中国科学院天津工业生物技术研究所，研究员 2013-10~2016-09,德国马普煤炭化学研究所, 博士后 2012-10~2013-09,新加坡南洋理工大学, 博士后研究员

研究领域

1. 生物催化与蛋白质工程：a）生物信息学挖掘新型工业用酶；b）生物催化剂的分子定向进化改造；c）计算机(In Silico)定向进化与设计；d) 新酶新反应设计与催化机制研究。 2. 工业微生物代谢工程与合成生物学。

近期论文

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Manfred T. Reetz, Ge Qu, Zhoutong Sun. Engineered enzymes for the synthesis of pharmaceuticals and other high-value products. Nature Synthesis[J]. 2024, 3: 19-32, Qiang Chen, Ge Qu, Xu Li, Mingjian Feng, Fan Yang, Yanjie Li, Jincheng Li, Feifei Tong, Shiyi Song, Yujun Wang, Zhoutong Sun, Guangsheng Luo. Active and stable alcohol dehydrogenase-assembled hydrogels via synergistic bridging of triazoles and metal ions. NATURE COMMUNICATIONS[J]. 2023, 14(1): 1-12, https://doaj.org/article/8a23f4f93e4849218588d536eb254723. Xiangying Li, Jingang Wang, Wencheng Su, Congcong Li, Ge Qu, Bo Yuan, Zhoutong Sun. Characterization and engineering of cephalosporin C acylases to produce 7-Aminocephalosporanic acid. MOLECULAR CATALYSIS. 2023, 550: http://dx.doi.org/10.1016/j.mcat.2023.113595. Manfred TReetz, Zhoutong Sun, Ge Qu. Book review of"Enzyme engineering:Selective catalysts for applications in biotechnology,organic chemistry,and life science". 绿色合成与催化(英文)[J]. 2023, 4(2): 77-77, http://lib.cqvip.com/Qikan/Article/Detail?id=7110661023. Jiapeng Lu, Zengyu Wang, Yingying Jiang, Zhoutong Sun, Wei Luo. Modification of the substrate specificity of leucine dehydrogenase by site‑directed mutagenesis based on biocomputing strategies. 系统微生物学与生物制造(英文). 2023, 3(2): 384-392, http://lib.cqvip.com/Qikan/Article/Detail?id=7110116051. Li, Yinuo, Bao, Cuiyu, Sun, Zhoutong, Zhang, Wuyuan, Yuan, Bo. Comparison between Chemoenzymatic and Bienzymatic Cascades Leading to Morita-Baylis-Hillman Adducts. CHEMCATCHEM[J]. 2023, 15(7): http://dx.doi.org/10.1002/cctc.202201621. Zhang, Jun, Liao, Daohong, Chen, Rongchang, Zhu, Fangfang, Ma, Yaqing, Gao, Lei, Qu, Ge, Cui, Chengsen, Sun, Zhoutong, Lei, Xiaoguang, Gao, ShuShan. Tuning an Imine Reductase for the Asymmetric Synthesis of Azacycloalkylamines by Concise Structure-Guided Engineering. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, 61(24): http://dx.doi.org/10.1002/anie.202201908. Wang, Peipei, Han, Xiaofeng, Liu, Xinqi, Lin, Richen, Chen, Yongzheng, Sun, Zhoutong, Zhang, Wuyuan. Synthesis of Enantioenriched Sulfoxides by an Oxidation-Reduction Enzymatic Cascade. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2022, 28(61): http://dx.doi.org/10.1002/chem.202201997. Jun-Kuan Li, Ge Qu, Xu Li, Yuchen Tian, Chengsen Cui, Fa-Guang Zhang, Wuyuan Zhang, Jun-An Ma, Manfred T. Reetz, Zhoutong Sun. Rational enzyme design for enabling biocatalytic Baldwin cyclization and asymmetric synthesis of chiral heterocycles. NATURE COMMUNICATIONS[J]. 2022, 13(1): http://dx.doi.org/10.1038/s41467-022-35468-y. Ge, Ran, Zhang, Pengpeng, Dong, Xuetian, Li, Yuanying, Sun, Zhoutong, Zeng, Yongyi, Chen, Bishuang, Zhang, Wuyuan. Photobiocatalytic Decarboxylation for the Synthesis of Fatty Epoxides from Renewable Fatty Acids. CHEMSUSCHEM[J]. 2022, 15(20): http://dx.doi.org/10.1002/cssc.202201275. Yingying Jiang, Ge Qu, Xiang Sheng, Feifei Tong, Zhoutong Sun. Unraveling the mechanism of enantio-controlling switches of an alcohol dehydrogenase toward sterically small ketone. Catalysis Science & Technology[J]. 2022, 12(6): 1777-1787, https://pubs.rsc.org/en/content/articlelanding/2022/cy/d2cy00031h/unauth. Jiang, Yingying, Li, Xu, Liu, Beibei, Tong, Feifei, Qu, Ge, Sun, Zhoutong. Engineering the hydrogen transfer pathway of an alcohol dehydrogenase to increase activity by rational enzyme design. MOLECULAR CATALYSIS[J]. 2022, 530: http://dx.doi.org/10.1016/j.mcat.2022.112603. Chen, Qiang, An, Yuchao, Feng, Mingjian, Li, Jincheng, Li, Yanjie, Tong, Feifei, Qu, Ge, Sun, Zhoutong, Wang, Yujun, Luo, Guangsheng. An enzyme-assembled gel monolithic microreactor for continuous flow asymmetric synthesis of aryl alcohols. GREEN CHEMISTRY[J]. 2022, 24(24): 9508-9518, http://dx.doi.org/10.1039/d2gc03082a. Bi, Huiping, Qu, Ge, Wang, Shuai, Zhuang, Yibin, Sun, Zhoutong, Liu, Tao, Ma, Yanhe. Biosynthesis of a rosavin natural product in Escherichia coli by glycosyltransferase rational design and artificial pathway construction. METABOLIC ENGINEERING[J]. 2022, 69: 15-25, Huang, Wansheng, Huang, Shengtang, Sun, Zhoutong, Zhang, Wuyuan, Zeng, Zhigang, Yuan, Bo. Chemoenzymatic Synthesis of Sterically Hindered Biaryls by Suzuki Coupling and Vanadium Chloroperoxidase Catalyzed Halogenations. CHEMBIOCHEM. 2022, 24(1): http://dx.doi.org/10.1002/cbic.202200610. Dong, Chen, Qu, Ge, Guo, Jinggong, Wei, Fang, Gao, Shuwen, Sun, Zhoutong, Jin, Lifeng, Sun, Xuwu, Rochaix, JeanDavid, Miao, Yuchen, Wang, Ran. Rational design of geranylgeranyl diphosphate synthase enhances carotenoid production and improves photosynthetic efficiency in Nicotiana tabacum. SCIENCE BULLETIN[J]. 2022, 67(3): 315-327, https://www.sciengine.com/doi/10.1016/j.scib.2021.07.003. Li, Yuanying, Zhang, Pengpeng, Sun, Zhoutong, Li, Huanhuan, Ge, Ran, Sheng, Xiang, Zhang, Wuyuan. Peroxygenase-Catalyzed Selective Synthesis of Calcitriol Starting from Alfacalcidol. ANTIOXIDANTS[J]. 2022, 11(6): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000817441100001. Wu, Xiaowen, Jiang, Yingying, Wang, Zengyu, Yu, Xiaobin, Sun, Zhoutong, Luo, Wei. Enhanced thermostability of formate dehydrogenase via semi-rational design. MOLECULAR CATALYSIS[J]. 2022, 530: http://dx.doi.org/10.1016/j.mcat.2022.112628. Sang, Xianke, Tong, Feifei, Zeng, Zhigang, Wu, Minghu, Yuan, Bo, Sun, Zhoutong, Sheng, Xiang, Qu, Ge, Alcalde, Miguel, Hollmann, Frank, Zhang, Wuyuan. A Biocatalytic Platform for the Synthesis of Enantiopure Propargylic Alcohols and Amines. ORGANIC LETTERS[J]. 2022, 24(23): 4252-4257, http://dx.doi.org/10.1021/acs.orglett.2c01547. Ming, Hui, Yuan, Bo, Qu, Ge, Sun, Zhoutong. Engineering the activity of amine dehydrogenase in the asymmetric reductive amination of hydroxyl ketones. CATALYSIS SCIENCE & TECHNOLOGY[J]. 2022, 12(19): 5952-5960, http://dx.doi.org/10.1039/d2cy00391k. Shiyi Song, Yingying Jiang, Ruidong Chen, Wencheng Su, Weinan Liang, Dameng Yang, Jincheng Li, Wuyuan Zhang, Shushan Gao, Bo Yuan, Ge Qu, Zhoutong Sun. Whole-cell Biotransformation of Penicillin G by a Three-enzyme Co-expression System with Engineered Deacetoxycephalosporin C Synthase. ChemBioChem[J]. 2022, e202200179-, https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202200179. Ge Qu, Yuexin Bi, Beibei Liu, Junkuan Li, Xu Han, Weidong Liu, Yingying Jiang, Zongmin Qin, Zhoutong Sun. Unlocking the stereoselectivity and substrate acceptance of enzymes: Proline induced loop engineering test. Angewandte Chemie International Edition[J]. 2022, 61(1): e202110793-, https://onlinelibrary.wiley.com/doi/10.1002/anie.202110793. Yu Zhipu, An Chunyan, Yao Yongpeng, Wang Changyun, Sun Zhoutong, Cui Chengsen, Liu Ling, Gao Shushan. A combined strategy for the overproduction of complex ergot alkaloid agroclavine. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY[J]. 2022, 7(4): 1126-1132, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7414703&detailType=1. Feifei Tong, Zongmin Qin, Hongyue Wang, Yingying Jiang, Junkuan Li, Hui Ming, Ge Qu, Yazhong Xiao, Zhoutong Sun. Biosynthesis of Chiral Amino Alcohols via an Engineered Amine Dehydrogenase in E. coli. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY[J]. 2022, 9: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766677/. Dameng Yang, Wencheng Su, Yingying Jiang, Shushan Gao, Xiangying Li, Ge Qu, Zhoutong Sun. Biosynthesis of β-lactam nuclei in yeast. Metabolic Engineering[J]. 2022, 72: 56-65, https://www.sciencedirect.com/science/article/pii/S1096717622000350?via%3Dihub. Wang, Juan, Qu, Ge, Xie, Leipeng, Gao, Chao, Jiang, Yingying, Zhang, YiHeng P Job, Sun, Zhoutong, You, Chun. Engineering of a thermophilic dihydroxy-acid dehydratase toward glycerate dehydration for in vitro biosystems. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2022, 106(9-10): 3625-3637, http://dx.doi.org/10.1007/s00253-022-11936-9. Zongmin Qin, Xiaohui Zhang, Xianke Sang, Wuyuan Zhang, Ge Qu, Zhoutong Sun. Carboxylic acid reductases enable intramolecular lactamization reactions. GREEN SYNTHESIS AND CATALYSIS[J]. 2022, 3(3): 294-297, http://dx.doi.org/10.1016/j.gresc.2022.05.009. Chen, Qiang, Guo, Mingzhao, Bi, Yuexin, Qu, Ge, Sun, Zhoutong, Wang, Yujun, Luo, Guangsheng. Whole-cell biocatalytic synthesis of S-(4-chlorophenyl)-(pyridin-2-yl) methanol in a liquid?liquid biphasic microreaction system. BIORESOURCE TECHNOLOGY[J]. 2021, 330: http://dx.doi.org/10.1016/j.biortech.2021.125022. Jiao Li, Ge Qu, Na Shang, Peng Chen, Yan Men, Weidong Liu, Zelong Mei, Yuanxia Sun, Zhoutong Sun. Near-perfect control of the regioselective glucosylation enabled by rational design of glycosyltransferases. GREEN SYNTHESIS AND CATALYSIS[J]. 2021, 2(1): 45-53, http://dx.doi.org/10.1016/j.gresc.2021.01.005.