个人简介

Prof. Roger Schibli is an Associate Professor in the Department of Chemistry and Applied Biosciences (ETH Zurich) since 2010, and Head of the Center for Radiopharmaceutical Science (CRS), a joint endeavor between the ETH Zurich, the Paul Scherrer Institute and the University Hospital Zurich. Prof. Schibli studied Chemistry at the University of Basel, Switzerland and performed his doctoral thesis under the supervision of Prof. Thomas Kaden. After his graduation, he spent two years at the University of Missouri-Columbia, MO as a post-doctoral fellow. He was appointed Assistant Professor (tenure track) for Therapeutics Technologies at the Institute of Pharmaceutical Sciences (ETH Zurich) in 2004 and was tenured in 2009.

研究领域

Radiopharmaceutical Science

Prof. Schibli's research interestscover targeted tumor diagnosis and therapy using radiolabeled compounds. Apart from the chemical modification and radioactive labeling of molecules, his group emphasizes on the biological and pharmacological characterization and optimization of the radioactive compounds including non-invasive PET and SPET imaging. New, medically relevant radionuclides for his pre-clinical and clinical studies are produced at the cyclotron and neutron facilities of the ETH and the Paul Scherrer Institute.

近期论文

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Meletta, Romana and Herde, Adrienne Müller and Chiotellis, Aristeidis and Malsor, Isa and Rancic, Zoran and Borel, Nicole and Ametamey, M. Simon and Krämer, Stefanie D. and Schibli, R. Evaluation of the radiolabeled boronic acid-based FAP Inhibitor MIP-1232 for atherosclerotic plaque imaging 2015, Molecules Milicevic Sephton, Selena and Müller Herde, Adrienne and Mu, Linjing and Keller, Claudia and Rüdisühli, Sonja and Auberson, Yves and Schibli, Roger and Krämer, Stefanie D. and Ametamey, Simon M. Preclinical evaluation and test-retest studies of [(18)F]PSS232, a novel radioligand for targeting metabotropic glutamate receptor 5 (mGlu5) 2015, European Journal of Nuclear Medicine and Molecular Imaging Akkus, Funda and Terbeck, Sylvia and Ametamey, Simon M. and Rufer, Michael and Treyer, Valerie and Burger, Cyrill and Johayem, Anass and Mancilla, Baltazar G. and Sovago, Judit and Buck, Alfred and Hasler, Gregor Metabotropic glutamate receptor 5 binding in patients with obsessive-compulsive disorder 2014, The international journal of neuropsychopharmacology Weiss, Andrea and Berndsen, Robert H. and Dubois, Maxime and Müller, Cristina and Schibli, Roger and Griffioen, Arjan W. and Dyson, Paul J. and Nowak-Sliwinska, Patrycja In vivo anti-tumor activity of the organometallic ruthenium(II)-arene complex [Ru(η6-p-cymene)Cl2(pta)] (RAPTA-C) in human ovarian and colorectal carcinomas 2014, Chemical science Burger, Irene A. and et al. and Schibli, Roger First Clinical Results of (d)-18F-Fluoromethyltyrosine (BAY 86-9596) PET/CT in Patients with Non–Small Cell Lung Cancer and Head and Neck Squamous Cell Carcinoma 2014, The Journal of Nuclear Medicine Grünberg, Jürgen and Lindenblatt, Dennis and Dorrer, Holger and Cohrs, Susan and Zhernosekov, Konstantin and Köster, Ulli and Türler, Andreas and Fischer, Eliane and Schibli, Roger Anti-L1CAM radioimmunotherapy is more effective with the radiolanthanide terbium-161 compared to lutetium-177 in an ovarian cancer model 2014, European journal of nuclear medicine and molecular imaging BIB Leopoldo, Marcello and Selivanova, Svetlana V. and Müller, Adrienne and Lacivita, Enza and Schetz, John A. and Ametamey, Simon M. n Vitro and In Vivo Evaluation of N-{2-[4-(3-Cyanopyridin-2-yl)piperazin-1-yl]ethyl}-3-[11C]methoxybenz­amide, a Positron Emission Tomography (PET) Radioligand for Dopamine D4 Receptors, in Rodents 2014, Chemistry & biodiversity Mueller, Adrienne and Kraemer, Stefanie D. and Meletta, Romana and Beck, Katharina and Selivanova, Svetlana V. and Rancic, Zoran and Kaufmann, Philipp A. and Vos, Bernhard and Meding, Jörg and Stellfeld, Timo and Heinrich, Tobias K. and Bauser, Marcus and Huetter, Joachim and Dinkelborg, Ludger M. and Schibli, Roger and Ametamey, Simon M. Gene expression levels of matrix metalloproteinases in human atherosclerotic plaques and evaluation of radiolabeled inhibitors as imaging agents for plaque vulnerability 2014, Nuclear medicine and biology Müller, Adrienne and Mu, Linjing and Meletta, Romana and Beck, Katharina and Rancic, Zoran and Drandarov, Konstantin and Kaufmann, Philipp A. and Ametamey, Simon M. and Schibli, Roger and Borel, Nicole and Krämer, Stefanie D. Towards non-invasive imaging of vulnerable atherosclerotic plaques by targeting co-stimulatory molecules 2014, International journal of cardiology Müller, Adrienne and Chiotellis, Aristeidis and Keller, Claudia and Ametamey, Simon M. and Schibli, Roger and Mu, Linjing and Krämer, Stefanie D. Imaging Tumour ATB0,+ Transport Activity by PET with the Cationic Amino Acid O-2((2-[18F]fluoroethyl)methyl-amino)ethyltyrosine 2014, Molecular imaging and biology Alf, Malte F. and Duarte, João M.N. and Lei, Hongxia and Krämer, Stefanie D. and Mlynarik, Vladimir and Schibli, Roger and Gruetter, Rolf MRS glucose mapping and PET joining forces 2014, Journal of Neurochemistry Hulka, Lea M. and et al. and Scheidegger, Milan and Johayem, Anass and Ametamey, Simon M. Smoking but not cocaine use is associated with lower cerebral metabotropic glutamate receptor 5 density in humans 2014, Molecular Psychiatry Müller, Cristina and Fischer, Eliane and Behe, Martin and Köster, Ulli and Dorrer, Holger and Reber, Josefine and Haller, Stephanie and Cohrs, Susan and Blanc, Alain and Grünberg, Jürgen and Bunka, Maruta and Zhernosekov, Konstantin and Meulen, Nicholas van der and Johnston, Karl and Türler, Andreas and Schibli, Roger Future prospects for SPECT imaging using the radiolanthanide terbium-155 - production and preclinical evaluation in tumor-bearing mice 2014, Nuclear Medicine and Biology Chiotellis, Aristeidis and Selivanova, Svetlana V. and Schweizer, Bernd and Schibli, Roger and Ametamey, Simon M. Studies toward terminal (fluoroalkyl)silanes 2014, Journal of Fluorine Chemistry Slavik, R. and Bieri, D. and Cermak, S. and Muller, A. and Kramer, S.D. and Weber, M. and Schibli, R. and Ametamey, S.M. and Mu, L.J. Development and Evaluation of Novel PET Tracers for Imaging Cannabinoid Receptor Type 2 in Brain 2014, Chimia Mu, Linjing and Slavik, Roger and Müller, Adrienne and Popaj, Kasim and Čermak, Stjepko and Weber, Markus and Schibli, Roger and Krämer, Stefanie D. and Ametamey, Simon M. Synthesis and preliminary evaluation of a 2-Oxoquinoline carboxylic acid derivative for PET imaging the cannabinoid type 2 receptor 2014, Pharmaceuticals Müller, Adrienne and Beck, Katharina and Rancic, Zoran and Müller, Cristina and Fischer, Cindy R. and Betzel, Thomas and Kaufmann, Philipp A. and Schibli, Roger and Krämer, Stefanie D. and Ametamey, Simon M. Imaging Atherosclerotic Plaque Inflammation via Folate Receptor Targeting Using a Novel F-18-Folate Radiotracer 2014, Molecular Imaging Müller, Cristina and Reber, Josefine and Haller, Stephanie and Dorrer, Holger and Bernhardt, Peter and Zhernosekov, Konstantin and Türler, Andreas and Schibli, Roger Direct in vitro and in vivo comparison of 161Tb and 177Lu using a tumour-targeting folate conjugate 2014, European journal of nuclear medicine and molecular imaging Müller, Cristina and Reber, Josefine and Haller, Stephanie and Dorrer, Holger and Köster, Ulli and Johnston, Karl and Zhernosekov, Konstantin and Türler, Andreas and Schibli, Roger Folate receptor targeted alpha-therapy using terbium-149 2014, Pharmaceuticals Bunka, M. and Muller, C. and Domnanich, K.A. and Schibli, R. and Turler, A. and Meulen, N.P. van der Sc-44 production development from Ca-44 for radiopharmaceutical application 2014, Nuclear medicine and biology