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个人简介

2009年7月于北京理工大学获应用化学工学博士学位,博士期间主要进行分子层层自组装微胶囊、利用表面仿生分子工程技术制备新型复合抗凝血材料方面的学习和研究工作。2009年7月-2011年7月于中国科学院高能物理研究所纳米生物效应与安全研究室博士后从事博士后研究,2011年7月出站后留所工作,2012年7月至今任副研究员。主要工作集中以水溶性富勒烯衍生物、石墨烯、聚合物纳米材料、金纳米颗粒、稀土元素纳米颗粒、量子点等纳米材料为研究对象,建立分离、制备方法,建立荧光标记、金属标记示踪方法,以及同步辐射和核技术,研究纳米材料的体外、体内安全性。在国际重要SCI刊物如Nano Scale, Nano Research, Nanomedicine等发表论文40余篇,他引600余次。累计申请专利8项和授权专利3项;主持和参与国家自然科学基金、科技部国家重大研究计划和北京市自然科学基金数项,应邀参加国际和国内学术会议数次。

研究领域

(1)富勒烯及金属富勒烯的生物效应及与肿瘤的高效低毒诊疗研究; (2)纳米药物的口服转运与转化过程中的安全性评价 ; (3)典型纳米载体与肠道微生物的相互作用研究。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

[1] Juan Li, R Lei, X Li, F Xiong, Q Zhang, Y Zhou, S Yang, Y Chang, K Chen, The antihyperlipidemic effects of fullerenol nanoparticles via adjusting the gut microbiota in vivo,Particle and Fibre Toxicology, 2018,15 (1), 5 [2]C Li, H Huang, R Cui, Juan Li, X Guo, H Yao, B Liu, B Xu, Y Li, S Liu, J Dong, Fluorescent activatable gadofullerene nanoprobes as NIR-MR dual-modal in vivo imaging contrast agent, Colloids and Surfaces B: Biointerfaces 2018,171, 159-166 [3] Juan Li, Shengmei Yang, Jiaqi Yu, Rongli Cui, Ru Liu, Runhong Lei ...Lipid- and Gut Microbiota-modulating Effects of Graphene Oxide Nanoparticles in High-fat Diet-induced Hyperlipidemic Mice. RSC Advances 2018,8, 31366 – 31371 [4] Juan Li, S Yang, R Cui, Y Chang, W Gu, X Guo, H Huang, K Chen, H Geng, ...The interactions between plasma proteins and fullerols by isothermal titration calorimetry,Nanomedicine: Nanotechnology, Biology and Medicine 2018,14 (5), 1781 [5] S Yang, F Xiong, K Chen, Y Chang, X Bai, W Yin, W Gu, Q Wang, Juan Li, ...Impact of Titanium Dioxide and Fullerenol Nanoparticles on Caco-2 Gut Epithelial Cells, Journal of nanoscience and nanotechnology 2018,18 (4), 2387-2393 [6] S Xia, J Li, M Zu, Juan Li, J Liu, X Bai, Y Chang, K Chen, W Gu, L Zeng, ...Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and FXa, Nanomedicine: Nanotechnology, Biology and Medicine 2018,14 (3), 929-939 [7] R Lei, X Bai, Y Chang, Juan Li, Y Qin, K Chen, W Gu, S Xia, J Zhang, Z Wang, ...Effects of Fullerenol Nanoparticles on Rat Oocyte Meiosis Resumption International journal of molecular sciences 2018,19 (3), 699 [8] S Ma, J Zhang, S Xia, W Yin, Y Qin, R Lei, L Mei, Juan Li*, G Xing*...Three-dimensional Angiography Fused with CT/MRI for Multimodal Imaging of Nanoparticles Based on Ba4Yb3F17: Lu3+, Gd3+,Nanoscale,2018 [9] Juan Li, S Yang, R Lei, W Gu, Y Qin, S Ma, K Chen, Y Chang, X Bai, S Xia, ...Oral administration of rutile and anatase TiO 2 nanoparticles shifts mouse gut microbiota structure,2018,Nanoscale 10 (16), 7736-7745 [10] W Gu, X Bai, K Ren, X Zhao, S Xia, J Zhang, Y Qin, R Lei, K Chen, Juan Li, Gengmei Xing, Mono-fullerenols modulating cell stiffness by perturbing actin bundling,Nanoscale 10 (4), 1750-1758 [11] J Yu, W Yin, T Peng, Y Chang, Y Zu, Juan Li, X He, X Ma, Z Gu, Y Zhao, Biodistribution, excretion, and toxicity of polyethyleneimine modified NaYF 4: Yb, Er upconversion nanoparticles in mice via different administration routes, Nanoscale,2017, 9 (13), 4497-4507 [12] H Geng, YN Chang, X Bai, S Liu, Q Yuan, W Gu, Juan Li, K Chen, G Xing,.. Fullerenol nanoparticles suppress RANKL-induced osteoclastogenesis by inhibiting differentiation and maturation, Nanoscale 2017, 9 (34), 12516-12523 [13] YN Chang, M Zhang Juan Li, K Chen, W Gu, G Xing,Utilizing a microfluidic device to enrich and fluorescently detect circulating tumor cells,Science Bulletin 2017, 7, 001 [14] W Yin, L Yan, J Yu, G Tian, L Zhou, X Zheng, X Zhang, Y Yong, Juan Li, Z Gu, High-Throughput Synthesis of Single-Layer MoS2 Nanosheets as a Near-Infrared Photothermal-Triggered Drug Delivery for Effective Cancer Therapy,2014,ACS nano 8 (7), 6922-6933 [15] K Chen, M Zhang, YN Chang, L Xia, W Gu, Y Qin, Juan Li, S Cui, G Xing, Utilizing gold nanoparticle probes to visually detect DNA methylation,Nanoscale research letters 2016, 11 (1), 304 7 [16] L Xia, W Gu, M Zhang, YN Chang, K Chen, X Bai, L Yu, Juan Li, S Li, G Xing, Endocytosed nanoparticles hold endosomes and stimulate binucleated cells formation, Particle and fibre toxicology, 2016, 13 (1), 63 7 [17] F Liu, F Xiong, Y Fan, Juan Li, H Wang, G Xing, F Yan, F Tai, R He, Facile and scalable fabrication engineering of fullerenol nanoparticles by improved alkaline-oxidation approach and its antioxidant potential in maize, Journal of Nanoparticle Research 2016,18 (11), 338 [18] F Xiong, Juan Li, H Wang, G Xing, R He, Evaluation of a series of different surface charged fullerenol nanoparticles as reactive oxygen species scavengers and potential cytoprotective agents, Journal of Nanoscience and Nanotechnology 2016,16 (7), 7170-7174 [19] J Jin, Y Dong, Y Wang, L Xia, W Gu, X Bai, Y Chang, M Zhang, K Chen, Juan Li, Gengmei Xing, Fullerenol Nanoparticles with structural activity induce variable intracellular actin filament morphologies, Journal of biomedical nanotechnology 2016,12 (6), 1234-1244 [20] Juan Li, W Yang, R Cui, D Wang, Y Chang, W Gu, W Yin, X Bai, K Chen, L Xia, Metabolizer in vivo of fullerenes and metallofullerenes by positron emission tomography,Nanotechnology, 2016, 27 (15), 155101 [21] Cheng Li, Rongli Cui, Liangzhu Feng, Juan Li, Huan Huang, Huanli Yao Synthesis of a UCNPs@SiO2@gadofullerene nanocomposite and its application in UCL/MR bimodal imaging,RSC Adv.2016, 101, 98968-98974 [22] Juan Li, R Cui, Y Chang, X Guo, W Gu, H Huang, K Chen, G Lin, J Dong, Adaption of the structure of carbon nanohybrids toward high-relaxivity for a new MRI contrast agent, RSC Advances,2016, 6 (63), 58028-58033 [23] R Cui, Juan Li, H Huang, M Zhang, X Guo, Y Chang, M Li, J Dong, B Sun, Novel carbon nanohybrids as highly efficient magnetic resonance imaging contrast agents, Nano Research 2015,8 (4), 1259-1268 [24] 桑维维, 常亚男, 李娟*,微流控芯片对乳腺癌细胞 MDA-MB-231 的捕获及再培养研究,中国生物工程杂志, 2015,35 (6), 46-53

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