个人简介
王海，国家纳米科学中心研究员，博士生导师。2013年在国家纳米科学中心获得博士学位。随后在俄亥俄州立大学和马里兰大学从事博士后和助理研究教授工作。2019年3月起在国家纳米科学中心工作，担任研究员和课题组长。研究工作聚焦于多尺度生物材料用于药物输送和组织修复，以药物运输和组织修复领域存在的难点问题为突破口，整合工程科学、生物学、纳米医学和材料学等多学科，从不同角度和方向研究药物可控运输和原位组织修复的新途径、新技术和新机制。近年来，在Nature Nanotechnology，Nature Communications, Advanced Materials, ACS Nano以及 Advanced Functional Materials 等杂志发表50余篇论文，多篇文章篇入选“ESI高被引论文”。主持国家及省部级项目多项项，包括科技创新2030-脑科学与类脑研究重大项目课题负责人、国家重点研发计划项目骨干、国家自然基金委面上项目等。担任中国生物物理学会材料生物学与智能诊疗技术分会委员、中国抗癌协会纳米肿瘤学专委会委员、中国生物材料学会纳米生物材料分会委员、中国微米纳米学会微纳机器人分会理事等社会职务。
研究领域
1.物质代谢调控下纳米药物设计、构筑和应用
2.纳米蛋白质调控技术
3.持久性纳米疫苗体系的构建
近期论文
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Jie Zhang, Biao Fan, Guoliang Cao, Wenping Huang, Fuhao Jia, Guangjun Nie, Hai Wang*. Direct Presentation of Tumor-Associated Antigens to Induce Adaptive Immunity by Personalized Dendritic Cell-Mimicking Nanovaccines. Advanced Materials. 2022, 202205950.
Fuhao Jia, Wenping Huang, Yue Yin, Yue Jiang, Qingzhen Yang, Haishui Huang, Guangjun Nie, Hai Wang*. Stabilizing RNA Nanovaccines with Transformable Hyaluronan Dynamic Hydrogel for Durable Cancer Immunotherapy. Advanced Functional Materials. 2022, doi.org/10.1002/adfm.202204636.
Ruihao Qian, Guoliang Cao, Wen Su, Jie Zhang, Yue Jiang, Haohao Song, Fuhao Jia, and Hai Wang*. Enhanced Sensitivity of Tumor Cells to Autophagy Inhibitors Using Fasting-Mimicking Diet and Targeted Lysosomal Delivery Nanoplatform. Nano Letters, 2022, doi.org/10.1021/acs.nanolett.2c03890.
Xinye Wang, Wen Su, Yongbin Jiang, Fuhao Jia, Wenping Huang, Jie Zhang, Yue Yin and Hai Wang*. Regulation of Nucleotide Metabolism with Nutrient-Sensing Nanodrugs for Cancer Therapy. Advanced Science. 2022, 9, 2200482.
Jiayi Zhang, Yue Yin, Jie Zhang, Jingran Zhang, Wen Su, Haixia Ma, Fuhao Jia, Guangjiu Zhao, and Hai Wang*. Suppression of Energy Metabolism in Cancer Cells with Nutrient-Sensing Nanodrugs. Nano Letters. 2022, 22, 2514-2520.
Yipeng Zhao, Siyu Tian, Jie Zhang, Xi Cheng, Wenping Huang, Guoliang Cao, Yan-Zhong Chang, Hai Wang*, Guangjun Nie*, Wei Qiu*. Regulation of neuroinflammation with GLP-1 receptor targeting nanostructures to alleviate Alzheimer’s symptoms in the disease models. Nano Today, 2022, 44, 101457.
Yue Yin, Wen Su, Jie Zhang, Wenping Huang, Xiaoyang Li, Haixia Ma, Mixiao Tan, Haohao Song, Guoliang Cao, Shengji Yu, Di Yu, Ji Hoon Jeong, Xiao Zhao, Hui Li*, Guangjun Nie*, Hai Wang*. Separable Microneedle Patch to Protect and Deliver DNA Nanovaccines Against COVID-19. ACS Nano. 2021, 15, 14347-14359.
Yue Yin, Xiaoyang Li, Haixia Ma, Jie Zhang, Di Yu, Ruifang Zhao, Shengji Yu, Guangjun Nie,* and Hai Wang*. In Situ Transforming RNA Nanovaccines from Polyethylenimine Functionalized Graphene Oxide Hydrogel for Durable Cancer Immunotherapy. Nano Letters. 2021, 10, 2224-2231.
Tie Chang, Oyawale Adetunji Moses, Conghui Tian, Hai Wang*, Li Song*, Gang Zhao*. Synergistic Ice Inhibition Effect Enhances Rapid Freezing Cryopreservation with Low Concentration of Cryoprotectants. Advanced Science. 2021, 2003387.
Fuhao Jia, Yanbing Gao, Hai Wang*. Recent Advances in Drug Delivery System Fabricated by Microfluidics uidics for Disease Therapy. Bioengineering. 2022, 9, 625. (Invited review)
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