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Ji, X.; Tu, J., Song, Y.; Zhang, C.; Wang, L.; Li, Q.;* Ju, J.* A luciferase-like monooxygenase and flavin reductase pair AbmE2/AbmZ catalyzes Baeyer–Villiger oxidation in neoabyssomicin biosynthesis. ACS Catalysis, 2020, 10, 2591-2595.
Shao, M.; Sun, C.; Liu, X. Wang, X.; Li, W.; Wei, X.; Li, Q;* Ju, J.* Upregulation of a marine fungal biosynthetic gene cluster by an endobacterial symbiont. Commun. Biol., 2020, https://doi.org/10.1038/s42003-020-01239-y.
Zhang, C.; Zhang, H.; Ju, J.* On-PKS Baeyer–Villiger-type O-atom insertion catalyzed by luciferase-like monooxygenase OvmO during olimycin biosynthesis. Org. Lett. 2020, 22, 1780-1784.
Chen, J.; Gui, C.; Wei, Q.; Liu, J.; Ye, L.; Tian, X.; Gu, Y.-C.; Li, Q.; Ju J.* Characterization of tailoring methyltransferases involved in K-41A biosynthesis: modulating methylation to improve K-41A anti-infective activity. Org. Lett. 2020, 22, 4627-4632.
Ji, X.; Dong, Y.; Ling, C.; Zhou, Z.; Li, Q.;* Ju, J.* Elucidation of the tailoring steps in julichrome biosysthesis by marine gastropod mullusk-associated Streptomyces sampsonii SCSIO 054. Org. Lett. 2020, 22, 6927-6931.
Li, Q.;* Ding, W.; Tu, J.; Huang, H.; Ji, X.; Yao, Z.; Ju, J.* Nonspecific heme-binding cyclase, Abm U, catalyzes [4 + 2] cycloaddition during neoabyssomicin biosynthesis. ACS Omega, 2020, 5, 20548-20557.
Sun, C.; Liu, Z.; Zhu, X.; Fan, Z.; Huang, X.; Wu, Q.; Zheng, X.; Qin, X.; Zhang, T.; Zhang, H.; Ju, J.;* Ma, J.* Anti-tubercular ilamycins from marine-derived Streptomyces atratus SCSIO ZH16 ∆ilaR. J. Nat. Prod. 2020, 83, 1646-1657.
Yang, Z.; Sun, C.; Liu, Z.; Liu, Q.; Zhang, T.; Ju, J.*; Ma, J.* Production of antitubercular depsipeptides via biosynthetic engineering of cinnamoyl units. J. Nat. Prod. 2020, 83, 1666-1673.
Zhou, Z.; Wu, Q.; Xie, Q.; Ling, C.; Zhang, H.; Sun, C.;* Ju, J.* New borrelidins from Onchidium sp. associated Streptomyces olivaceus SCSIO LO13. Chem. Biodiver. 2020, 17(1), e1900560, doi: 10.1002/cbdv.201900560.
Dong, Y.; Ding, W.; Sun, C.; Ji, X.; Ling, C.; Zhou, Z.; Chen, Z.; Chen, X.;* Ju, J.* Julichrome monomers from marine gastropod mullusk-associated Streptomyces and stereochemical revision of julichrome Q3·5 and Q3·3. Chem. Biodiver. 2020, 17, e2000057.
Ding, W.; Dong, Yu.; Ju, J.;* Li, Q.* The roles of genes associated with regulation, transportation, and macrocyclization in desotamide biosynthesis in Streptomyces scopuliridis SCSIO ZJ46. Appl. Microbiol. Biotechnol. 2020, 104, 2603-2610.
Yang, Z.; He, J.; Wei, X.; Ju, J.; Ma, J.* Exploration and genome mining of natural products from marine Streptomyces. Appl. Microbiol. Biotechnol. 2020, 104, 67-76.
Song, Y.; Yang, J.; Yu, J.; Li, J.; Yuan, J.; Wong, N.-K.; Ju, J.* Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities. J. Antibiot. 2020, 73(8):542-547.
He, J.; Wei, X.; Yang, Z.; Li, Y.; Ju, J.; Ma, J.* Characterization of regulatory and transporter genes in the biosynthesis of anti-tuberculosis ilamycins and production in a heterologous host. Mar Drugs. 2020, 18(4). pii: E216. doi: 10.3390/md18040216.
Zhou, W.; Liang, H.; Qin, X.; Cao, D.; Zhu, X.; Ju, J.; Shen, B.; Duan, Y.;* Huang, Y.* The isolation of pyrroloformamide congeners and characterization of their biosynthetic gene cluster. J. Nat. Prod. 2020, 83, 202-209.
Liu, L.; Li, S.; Sun, R.; Qin, X.; Ju, J.; Zhang, C.; Duan, Y.;* Huang, Y.* Activation and characterization of bohemamine biosynthetic gene cluster from Streptomyces sp. CB02009. Org Lett. 2020, doi: 10.1021/acs.orglett.0c01224.
Yang Z, He J, Wei X, Ju J, Ma J.* Exploration and genome mining of natural products from marine Streptomyces. Appl Microbiol Biotechnol. 2020, 104, 67-76.
Hou, L.; Liu, Z.; Yu, D.; Li, H.; Ju, J.; Li, W.* Targeted isolation of new polycyclic tetramate macrolactams from the deepsea-derived Streptomyces somaliensis SCSIO ZH66. Bioorg. Chem. 2020, doi: 10.1016/j.bioorg.2020.103954.
Kumar, P. S.; Ling, C. Y.; Zhou, Z. B.; Dong, Y.; Sun, C.; Song, Y. X.; Wong, N.-K.; Ju, J. H. * Chemical diversity and antibacterial potential of actinomycetes associated with marine invertebrates from intertidal regions of Daya Bay and Nansha Islands. Microbiology, 2020, 89(4), 483-492.
Wang, L.; Li, M.; Lin, Y.; Du, S.; Liu, Z.; Ju, J.; Suzuki, H.; Sawada, M.; Umezawa, K.* Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin. J. Antibiot (Tokyo). 2020, doi: 10.1038/s41429-020-0302-9
Yao, Y.; Sun, S.; Cao, M.; Mao, M.; He, J.; Gai, Q.; Qin, Y.; Yao, X.; Lu, H.; Chen, F.; Wang, W.; Luo, M.; Zhang, H.; Huang, H.; Ju, J.; Bian, X.W.,* Wang, Y.* Grincamycin B functions as a potent inhibitor for glioblastoma stem cell via targeting RHOA and PI3K/AKT. ACS Chem. Neurosci. 2020, doi: 10.1021/acschemneuro.0c00206.
Wang, Z.; Li, ZX.; Zhao, WC.; Huang, HB.; Wang, JQ.; Zhang, H.; Lu, JY.; Wang, RN.; Li, W.; Cheng, Z.; Xu, WL.; Zhu, D.; Zhou, LS.; Jiang, W.; Yu, L.; Liu, JY.; Luo, C.; Zhu, H.; Dan, Ye.; Pan, WJ.; Ju, JH.; Dang, YJ.* Identification and characterization of isocitrate dehydrogenase 1(IDH1) as a functional target of marine natural product grincamycin B. Acta. Pharmacol. Sin. 2020, doi: 10.1038/s41401-020-0491-6.
Gui, C.; Chen, J.; Xie, Q.; Mo, X.; Zhang, S.; Zhang, H.; Ma, J.; Li, Q.; Gu, Y-C.; Ju, J.* CytA, a reductase in the cytorhodin biosynthesis pathway, inactivates anthracycline drugs in Streptomyces. Commun. Biol., 2019, 2:454 (https://doi.org/10.1038/s42003-019-0699-5).
Liu, Q.; Liu, Z.; Sun, C.; Shao, M.; Ma, J.; Wei, X.; Zhang, T.;* Li, W.;* Ju, J.* Discovery and biosynthesis of atrovimycin, an antitubercular and antifungal cyclodepsipeptide featuring vicinal-dihydroxylated cinnamic acyl chain. Org. Lett. 2019, 21, 2634-2638.
Sun, C.; Yang, Z.; Zhang, C.; Liu, Z.; He, J.; Liu, Q.; Zhang, T.; Ju, J.;* Ma, J.* Genome mining of Streptomyces atratus SCSIO ZH16: discovery of atratumycin and identification of its biosynthetic gene cluster. Org. Lett. 2019, 21, 1453-1457.
Xie, Q.;# Yang, Z.;# Huang, X.; Zhang, Z.; Li. J.; Ju, J.;* Zhang, H. ,* Ma, J. * Ilamycin C induces apoptosis and inhibits migration and invasion in triple-negative breast cancer by suppressing IL-6/STAT3 pathway. J. Hematol.Oncol. 2019, 12(1):60. doi:10.1186/s13045-019-0744-3.
Zhang, S.; Xie, Q.; Sun, C.; Tian, X.-P.; Gui, C.; Qin, X-J.; Zhang, H.;* Ju, J.* Cytotoxic kendomycins containing the carbacylic ansa scaffold from marine-derived Verrucosispora sp. SCSIO 07399. J. Nat. Prod. 2019, 82, 3366-3371.
Luo, M.; Zang, R.; Wang, X.; Chen, Z.; Song, X.; Ju, J.;* Huang, H.* Natural hydroxamate-containing siderophore acremonpeptides A-D and an aluminum complex of acremonpeptide D from Marine-derived Acremoniumpersicinum SCSIO 115. J. Nat. Prod. 2019, 82, 2594-2600.
Zhu, Q.; Song, Y.; Huang, H.; Li, Q.;* Ju, J.* Characterization of MtdV as a chorismate lyase essential to A201A biosynthesis and precursor-directed biosynthesis of new analogs. Org. Biomol. Chem. 2019, 17, 3760-3764.
Pan, H.; Tian X.-P.; Shao, M.; Xie, Y.; Huang, H.; Hu, J.; Ju, J.* Genome mining and metabolic profiling illuminate the chemistry driving diverse biological activities of Bacillus siamensis SCSIO 05746. Appl. Microbiol. Biotechnol. 2019, 103(10), 4153-4165.
Shao, M.; Ma, J.; Li, Q.; Ju, J.* Identification of the anti-infective aborycin biosynthetic gene cluster from deep sea-derived Streptomyces sp. SCSIO ZS0098 enables production in a heterologous host. Mar. Drugs. 2019, 17(2). pii: E127; doi:10.3390/md17020127.
Liu, M.; Jia, Y.; Xie, Y.; Zhang, C.; Ma, J.; Sun, C.; Ju, J.* Identification of the actinomycin D biosynthetic pathway from marine-derived Streptomyces costaricanus SCSIO ZS0073. Mar. Drugs. 2019, 17, 240; doi:10.3390/md17040240.
Zhang, C.; Ding, W.; Qin, X.; Ju J.* Genome sequencing of Streptomyces olivaceus SCSIO T05 and activated production of lobophorin CR4 via metabolic engineering and genome mining. Mar Drugs. 2019,17(10). pii: E593. doi: 10.3390/md17100593.
Yang, Z.; Wei, X.; He, J.; Ju, J.;* and Ma, J.* Characterization of the noncanonical regulatory and transporter genes in atratumycin biosynthesis and production in a heterologous host. Mar. Drugs. 2019, 17(10). pii: E560. doi: 10.3390/md17100560.
Xie, Y.; Li, Q.; Qin, X.; Ju, J. ;* Ma, J.* Enhancement of himastatin bioproduction via inactivation of atypical repressors in Streptomyces hygroscopicus. Metab. Eng. Commun., 2019, 8:e00084; https://doi.org/10.1016/j.mec.2018.e00084.
Huang, H.; Song, Y.; Zang, R.; Wang, X.; Ju, J.* Octyl substituted butenolides from marine-derived Streptomyces koyangensis. Nat Prod Res. 2019 Nov 6:1-6. doi: 10.1080/14786419.2019.1686368.
Zhou, W.; Fang, H.; Wu, Q.; Wang, X.; Liu R.; Li, F.; Xiao, J.; Yuan, L.; Zhou, Z.; Ma, J.; Wang, L.; Zhao, W.; You, H.; Ju, J.; Feng, J.;* Chen, C.* Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2. Int. J. Biol. Sci. 2019, 15(8), 1723-1732.
Meng, L.; Sun, C.; Zhang, C.; Song, S.; Sun, X.; Ju, J.; Deng Y.* Efficacy of compounds isolated from Streptomyces olivaceus against the morphogenesis and virulence of Candida albicans. Mar Drugs. 2019, 17(8), pii: E442.
Jiang, L.; Pu, H.; Qin, X.; Liu, J.; Wen, Z.; Huang, Y.; Xiang, J.; Xiang, Y.; Ju, J.; Duan, Y.;* Huang, Y.* Syn-2, 3-diols and anti-inflammatory indole derivatives from Streptomyces sp. CB09001. Nat Prod Res. 2019, 1-8. doi: 10.1080/14786419.2019.1611812.
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