个人简介

Jean-Christophe Leroux is full Professor in Drug Formulation and Delivery at ETH Zurich. Dr. Leroux was born in Montreal (Canada) in 1969. He received his B.Pharm. from the University of Montreal, followed by a Ph.D. in Pharmaceutical Sciences (1995) from the University of Geneva (Switzerland). From 1996 to 1997 he completed a postdoctoral training at the University of California, San Francisco and then joined the University of Montreal as an assistant professor. He was promoted to the ranks of associate professor in 2002 and full professor in 2007. In 2001, he was awarded the Canada Research Chair in Drug Delivery. Prof. Leroux joined the Institute of Pharmaceutical Sciences at ETHZ as ordinary professor at the end of 2008.

研究领域

Drug Formulation & Delivery

His research interests include the design of novel biopolymers, stimuli-responsive drug delivery systems (liposomes, micelles and gels) and the targeting of anticancer drugs. Recently he has been involved in the development of polymer therapeutics for Celiac disease. He is the author or coauthor of numerous refereed articles, book chapters and patents/patent applications in the field of drug delivery. He is the associate editor of the European Journal of Pharmaceutics and Biopharmaceutics and serves in the editorial board of several journals including the Journal of Controlled Release and the Journal of Pharmaceutical Sciences. He has received several prestigious distinctions and fellowships including the CRS-Capsugel (1997 and 2003), AFPC-Astra Zeneca (2003) and CRS young investigator awards (2004) and the Steacie Fellowships (2008) for innovative research in pharmaceutical technology.

近期论文

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Brülisauer, Lorine and Gauthier, Marc A. and Leroux, Jean-Christophe Disulfide-containing parenteral delivery systems and their redox-biological fate 2014, Journal of controlled release McCarville, Justin L. and et al. and Leroux, Jean-Christophe BL-7010 Demonstrates Specific Binding to Gliadin and Reduces Gluten-Associated Pathology in a Chronic Mouse Model of Gliadin Sensitivity 2014, PLOS ONE Forster, Vincent and Signorell, Rea D. and Roveri, Maurizio and Leroux, Jean-Christophe Liposome-supported peritoneal dialysis for detoxification of drugs and endogenous metabolites 2014, Science Translational Medicine Brambilla, Davide and Luciani, Paola and Leroux, Jean-Christophe Breakthrough discoveries in drug delivery technologies 2014, Journal of controlled release Lee, Soo Hyeon and Moroz, Elena and Castagner, Bastien and Leroux, Jean-Christophe Activatable Cell Penetrating Peptide-Peptide Nucleic Acid Conjugate via Reduction of Azobenzene PEG Chains 2014, Journal of the American Chemical Society Brülisauer, Lorine and Valentino, Gina and Morinaga, Sakura and Cam, Kübra and Bukrinski, Jens Thostrup and Gauthier, Marc A. and Leroux, Jean-Christophe Bio-reduction of Redox-Sensitive Albumin Conjugates in FcRn-Expressing Cells 2014, Angewandte Chemie. International edition in English Fuhrmann, Kathrin and Gauthier, Marc A. and Leroux, Jean-Christophe Targeting of Injectable Drug Nanocrystals 2014, Molecular pharmaceutics Sotiriou, Georgios A. and Starsich, Fabian and Dasargyri, Athanasia and Wurnig, Moritz C. and Krumeich, Frank and Boss, Andreas and Leroux, Jean-Christophe and Pratsinis, Sotiris E. Photothermal Killing of Cancer Cells by the Controlled Plasmonic Coupling of Silica-Coated Au/Fe2O3 Nanoaggregates 2014, Advanced functional materials Buerkli, Christian and Lee, Soo H. and Moroz, Elena and Stuparu, Mihaiela C. and Leroux, Jean-Christophe and Khan, Anzar Amphipathic Homopolymers for siRNA Delivery 2014, Biomacromolecules Fuhrmann, Gregor and Leroux, Jean-Christophe Improving the Stability and Activity of Oral Therapeutic Enzymes—Recent Advances and Perspectives 2014, Pharmaceutical research Katrin S. Blum, and Karaman, Sinem and Proulx, Steven T. and Ochsenbein, Alexandra M. and Luciani, Paola and Leroux, Jean-Christophe and Wolfrum, Christian and Detmar, Michael Chronic high-fat diet impairs collecting lymphatic vessel function in mice 2014, PLoS ONE Liu, Mi and Johansen, Pål and Zabel, Franziska and Leroux, Jean-Christophe and Gauthier, Marc A. Semi-permeable coatings fabricated from comb-polymers efficiently protect proteins in vivo 2014, Nature Communications Pouponneau, Pierre and Soulez, Gilles and Beaudoin, Gilles and Leroux, Jean-Christophe and Martel, Sylvain MR Imaging of Therapeutic Magnetic Microcarriers Guided by Magnetic Resonance Navigation for Targeted Liver Chemoembolization 2014, Cardiovascular and interventional radiology Proulx, Steven T. and Dieterich, Lothar C. and Karaman, Sinem and Leroux, Jean-Christophe and Detmar, Michael Expansion of the lymphatic vasculature in cancer and inflammation 2013, Journal of Controlled Release Catrina, Stefan and Gander, Bruno and Madduri, Srinivas Nerve conduit scaffolds for discrete delivery of two neurotrophic factors 2013, European journal of pharmaceutics and biopharmaceutics Fuhrmann, Kathrin and Połomska, Anna and Aeberli, Carmen and Castagner, Bastien and Gauthier, Marc A. and Leroux, Jean-Christophe Modular Design of Redox-Responsive Stabilizers for Nanocrystals 2013, ACS nano Lee, Soo Hyeon and Castagner, Bastien and Leroux, Jean-Christophe Is there a future for cell-penetrating peptides in oligonucleotide delivery? 2013, European journal of pharmaceutics and biopharmaceutics Pratsinis, Anna and Hervella, Pablo and Leroux, Jean-Christophe and Pratsinis, Sotiris E. and Sotiriou, Georgios A. Toxicity of Silver Nanoparticles in Macrophages 2013, Small Fuhrmann, Gregor and Grotzky, Andrea and Lukic, Ruzica and Matoori, Simon and Luciani, Paola and Yu, Hao and Zhang, Baozhong and Walde, Peter and Schlüter, A. Dieter and Gauthier, Marc A. and Leroux, Jean-Christophe Sustained gastrointestinal activity of dendronized polymer-enzyme conjugates 2013, Nature Chemistry Proulx, Steven T. and Luciani, Paola and Alitalo, Annamari and Mumprecht, Viviane and Christiansen, Alisa J. and Huggenberger, Reto and Leroux, Jean-Christophe and Detmar, Michael Non-invasive dynamic near-infrared imaging and quantification of vascular leakage in vivo 2013, Angiogenesis