个人简介
Jonathan Hall received his Ph.D. in Organic Chemistry at Imperial College of Science and Technology in London in 1988. He did post-doctoral studies with Nobel Laureate Prof. J.-M. Lehn at Université Louis Pasteur on a Royal Society Fellowship and with Prof. Y. Kishi at Harvard University. He joined Ciba Central Research Laboratories in 1992 where he worked on oligonucleotide artificial ribozymes. In 1997, after the Ciba-Sandoz merger, he became Project Head in the new Functional Genomics Department, responsible for application of antisense technologies for the identification of new targets in drug discovery. In 2000 he was promoted to Unit Head of Nucleic Acids Sciences. His group established a high-throughput oligonucleotide synthesis and screening facility dedicated to the assembly of a genome-wide library of siRNAs, which was used in some of the first whole genome siRNA screens. In collaboration with the Neuroscience Department his group developed methods to apply RNAi in vivo which resulted in early publications and patents describing the therapeutic effects of siRNAs in validated models of pain. In 2003, he received the -Novartis Leading Scientist- award. In collaboration with Prof. W. Filipowicz, at the Friedrich Miescher Institute, his group began work in the area of non-coding RNAs which culminated in the development of a microarray used for expression profiling of microRNAs. In 2005 he became Head of the Platform and Chemical Biology Department of Novartis.
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Imig, Jochen and Brunschweiger, Andreas and Brümmer, Anneke and Guennewig, Boris and Mittal, Nitish and Kishore, Shivendra and Tsikrika, Panagiota and Gerber, André P. and Zǎvolan, Mihaela and Hall, Jonathan, "miR-CLIP capture of a miRNA targetome uncovers a lincRNA H19–miR-106a interaction", 2015, Nature Chemical Biology
Roos, Martina and Rebhan, Mario A.E. and Lucic, Matije and Pavlicek, David and Pradère, Ugo and Towbin, Harry and Civenni, Gianluca and Catapano, Carlo V. and Hall, Jonathan, "Short loop-targeting oligoribonucleotides antagonize Lin28 and enable pre-let-7 processing and suppression of cell growth in let-7-deficient cancer cells", 2015, Nucleic Acids Research
Cienikova, Zuzana and Darriberger, Fred F. and Hall, Jonathan and Allain, Frederic H.-T. and Maris, Christophe, "Structural and Mechanistic Insights into Poly(uridine) Tract Recognition by the hnRNP C RNA Recognition Motif", 2014, Journal of the American Chemical Society
Lightfoot, Helen L. and Hall, Jonathan, "Endogenous polyamine function--the RNA perspective", 2014, Nucleic acids research
Franzini, Raphael M. and Samain, Florent and Abd Elrahman, Maaly and Mikutis, Gediminas and Nauer, Angela and Zimmermann, Mauro and Scheuermann, Jörg and Hall, Jonathan and Neri, Dario, "Systematic evaluation and optimization of modification reactions of oligonucleotides with amines and carboxylic acids for the synthesis of dna-encoded chemical libraries", 2014, Bioconjugate chemistry
Dogar, Afzal M. and Semplicio, Giuseppe and Guennewig, Boris and Hall, Jonathan, "Multiple microRNAs Derived from Chemically Synthesized Precursors Regulate Thrombospondin 1 Expression", 2014, Nucleic Acid Therapeutics
Gebert, Luca F.R. and Rebhan, Mario A.E. and Crivelli, Silvia E.M. and Denzler, Rémy and Stoffel, Markus and Hall, Jonathan, "Miravirsen (SPC3649) can inhibit the biogenesis of miR-122", 2014, Nucleic acids research
Brunschweiger, Andreas and Hall, Jonathan, "Medicinal Chemistry in the Context of the Human Genome", 2014, Methods and principles in medicinal chemistry
Guennewig, Boris and Roos, Martina and Dogar, Afzal M. and Gebert, Luca F.R. and Zagalak, Julian A. and Vongrad, Valentina and Metzner, Karin J. and Hall, Jonathan, "Synthetic pre-microRNAs reveal dual-strand activity of miR-34a on TNF-α", 2014, RNA
Pradère, Ugo and Brunschweiger, Andreas and Gebert, Luca F.R. and Lucic, Matije and Roos, Martina and Hall, Jonathan, "Chemical Synthesis of Mono- and Bis-Labeled Pre-MicroRNAs", 2013, Angewandte Chemie International edition in English
Rebhan, Mario A.E. and Brunschweiger, Andreas and Hall, Jonathan, "Measurement by SPR of Very Low Dissociation Rates", 2013, ChemBioChem
Towbin, Harry and Wenter, Philipp and Guennewig, Boris and Imig, Jochen and Zagalak, Julian A. and Gerber, André P. and Hall, Jonathan, "Systematic screens of proteins binding to synthetic microRNA precursors", 2013, Nucleic Acids Research
Lightfoot, Helen L. and Hall, Jonathan, "Target mRNA inhibition by oligonucleotide drugs in man", 2012, Nucleic Acids Research
Brunschweiger, Andreas and Hall, Jonathan, "A Decade of the Human Genome Sequence", 2012, ChemMedChem
Guennewig, Boris and Stoltz, Moritz and Menzi, Mirjam and Dogar, Afzal M. and Hall, Jonathan, "Properties of N(4)-Methylated Cytidines in miRNA Mimics", 2012, Nucleic Acid Therapeutics
Loughlin, Fionna E. and Gebert, Luca F.R. and Towbin, Harry and Brunschweiger, Andreas and Hall, Jonathan and Allain, Frédéric H.-T., "Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28", 2012, Nature structural & molecular biology
Hall, Jonathan and Dogar, Afzal M. and Towbin, Harry, "A microrna-mediated regulatory feedback loop in a new mechanism of resistance to TGF-beta induced growth inhibition", 2011, Nucleic Acid Therapeutics
Dogar, Afzal M. and Towbin, Harry and Hall, Jonathan, "Suppression of Latent Transforming Growth Factor (TGF)-beta 1 Restores Growth Inhibitory TGF-beta Signaling through microRNAs", 2011, The journal of biological chemistry
Hall, Jonathan and Dennler, Patrick and Haller, Stephanie and Pratsinis, Anna and Saeuberli, Katharina and Towbin, Harry and Walthe, Katja and Woytschak, Janine, "Genomics drugs in clinical trials", 2010, Nature reviews. Drug discovery
Fumagalli, Stefano and Di Cara, Alessandro and Neb-Gulati, Arti and Natt, Francois and Schwemberger, Sandy and Hall, Jonathan and Babcock, George F. and Bernardi, Rosa and Pandolfi, Pier Paolo and Thomas, George, "Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction", 2009, Nature Cell Biology
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