个人简介

Hanns Ulrich Zeilhofer has been Full Professor for Pharmacology at the ETH Zurich since January 1st, 2006 (dual-professorship, University of Zurich). Hanns Ulrich Zeilhofer was born in 1963 in Erlangen (Germany). He studied Medicine and Physics at the University of Erlangen-Nürnberg, before he received postdoctoral training in electrophysiology at the Max-Planck-Institute for Biophysical Chemistry in Göttingen (Prof. Erwin Neher and Dieter Swandulla) and in Molecular Biology at the Institute of Pharmacology and Toxicology, University of Zurich (Prof. Hanns Möhler). He made his MD thesis at the Institute of Pharmacology and Toxicology at the University of Erlangen-Nürnberg (Prof. Kay Brune). From 2001 to 2005 he was associate professor of Molecular Neuropharmacology at the Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nürnberg. In September 2005 he joined the Institute of Pharmacology and Toxicology, University of Zurich, as full professor of Pharmacology.

研究领域

Pharmacology

Current research projects focus on the neurobiological basis of pain. His group studies plastic changes in neuronal communication underlying pathological pain syndromes. These studies employ electrophysiological and optical techniques in slices of the spinal cord, molecular biology techniques as well as the behavioral testing of genetically modified animals. The research aims at the identification of novel pharmacological strategies for the treatment of pain.

近期论文

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Husson Z, Rousseau CV, Broll I, Zeilhofer HU, Dieudonné S: Differential GABAergic and glycinergic inputs of inhibitory interneurons and purkinje cells to principal cells of the cerebellar nuclei J Neurosci. 2014 Jul 9;34(28):94118-31 Maier PJ, Zemoura K, Acuna MA, Yévenes GE, Zeilhofer HU, Benke D: Ischemia-like oxygen and glucose deprivation mediates down-regulation of cell surface y-aminobutyric acidB receptors via the endoplasmic reticulum (ER) stress-induced transcription factor CCAAT/enhancer-binding protein (C/EBP)-hmologous protein (CHOP) Biol Chem. 2014 May 2;289(18):12896-907 Harkany T, Zeilhofer HU, Cattaneo A: Neurotrophin and endocannabinoid interactions in the neurobiology of pain Eur J Neurosci. 2014 Feb, 39(3):331-3 Hermann M, Stillhard P, Wildner H, Seruggia D, Kapp V, Sanchez-Iranzo H, Mercader N, Montoliu L, Zeilhofer HU, Pelczar P: Binary recombinase systems for high-resolution conditional mutagenesis Nucleic Acids Res. 2014 Jan 9 Punnakkal P, von Schoultz C, Haenraets K, Wildern H, Zeilhofer HU: Morphological, biophysical and synaptic properties of glutamatergic neurons of the mouse spinal dorsal horn J Physio. 2014 Feb 15, 592(Pt4):759-76 Paul J, Yévenes GE, Benke D, Di Lio AD, Ralvenius WT, Witschi R, Scheurer L, Cook JM, Rudolph U, Fritschy JM, Zeilhofer HU: Antihyperalgesia by a2-GABAA Receptors Occurs Via a Genuine Spinal Action and Does Not Involve Supraspinal Sites. Neuropsychopharmacology 2014 Jan, 39(2):477-87 Zemoura K, Schenkel M, Acuna MA, Yévenes GE, Zeilhofer HU, Benke D: Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors J Biol Chem. 2013 Nov 29, 288(48):34897-905 Wildner H, Das Gupta R, Bröhl D, Heppenstall PA, Zeilhofer HU, Birchmeier C: Genome-wide expression analysis of pft1a- and ascl1-deficient mice reveals new markers for distinct dorsal horn interneuron populations contributing to nociceptive reflex plasticity. J Neurosci. 2013 April 24, 33(17):7299-307 Tyagarajan SK, Ghosh H, Yévenes GE, Imanishi SY, Zeilhofer HU, Gerrits B, Fritschy JM: Exracellular signal-regulated kinase and glycogen synthase kinase 3Beta regulate gephyrin postsynaptic aggregation and GABergic synaptic function in a calpain-dependent mechanism. J Biol Chem. 2013 April 5, 288(14):9634-47 Besson M, Daali Y, Lio AD, Dayer P, Zeilhofer HU, Desmeules J: Antihyperalgesic Effect of the GABAB Ligand Clobazam in a Neuropathic Pain Model in Mice: A Pharmacokinetic-Pharmacodynamic Study. Basic Clin Pharmacol Toxicol. 2012 Sept, (Epub ahead of print) Kato A, Punnakkal P, Pernia-Andrade AJ, von Schoultz C, Sharopov S, Nyilas R, Katona I, Zeilhofer HU: Endocannabinoid-dependent plasticity at spinal nociceptor synapses. J. Physiol. 2012 Oct, 590(Pt 19):4717-33 Benke D, Zeilhofer HU: Divorce of obligatory partners in pain: disruption of GABAB receptor heterodimers in neuralgia. EMBO J 2012 Aug, 31(15):3234-6 Bosshard SC, Grandjean J, Schroeter A, Baltes C, Zeilhofer HU, Rudin M: Hyperalgesia by low doses of the local anesthetic lidocaine involves cannabinoid signaling: An fMRI study in mice. Pain 2012 Jul, 153(7):1450-8 Paul J, Zeilhofer HU, Fritschy JM: Selective distribution of GABAA receptor subtypes in mouse spinal dorsal horn neurons and primary afferents. J Comp Neurol. 2012 Dec, 520(17):3895-911 Zeilhofer HU, Wildner H, Yévenes GE: Fast synaptic inhibition in spinal sensory processing and pain control. Physiol Rev. 2012 Jan, 92(1):193-235 Zeilhofer HU, Benke D, Yévenes GE: Chronic Pain States: Pharmacological strategies to restore diminished inhibitory spinal pain control. Annu. Rev. Pharmacol. Toxicol. 2012 Feb, 52:111-33 Zeilhofer HU: Spinal Neuroplasticity in chronic pain. e-Neuroforum. 2011, 2:35-41 Yévenes GE, Zeilhofer HU: Molecular sites for the positive allosteric modulation of glycine receptors by endocannabinoids. PLoS One. 2011;6(8):e23886 (Epub Aug 25.) Witschi R, Punnakkal P, Paul J, Walczak JS, Cervero F, Fritschy JM, Kuner R, Keist R, Rudolph U, Zeilhofer HU: Presynaptic (alpha)2-GABAA Receptors in Primary Afferent Depolarization and Spinal Pain Control. J Neurosci. 2011 1;31(22):8134-8142 Yévenes GE, Zeilhofer HU: Allosteric Modulation of Glycine Receptors. Br J Pharmacol. 2011 May Johansson T, Narumiya S, Zeilhofer HU: Contribution of peripheral versus central EP1 prostaglandin receptors to inflammatory pain. Neurosci Lett. 2011 May16;495(2):98-101 Di Lio A, Benke D, Besson M, Desmeules J, Daali Y, Wang Z, Edwankar R, Cook J, Zeilhofer HU: HZ166, a novel GABA-A receptor subtype-selective benzodiazepine site ligand, is antihyperalgesic in mouse models of inflammatory and neuropathic pain. Neuropharmacology 2011 Mar;60(4):626-32 Röhn TA, Ralvenius WT, Paul J, Borter P, Hernandez M, Witschi R, Grest P, Zeilhofer HU, Bachmann NF, Jennings GT: A VLP-based anti-NGF vaccine reduces inflammatory hyperalgesia: potential long-term therapy for chronic pain. J Immunol 2011 Feb 1;186(3):1769-80 Tyagarajan S, Ghosh H, Yevenes GE, Nikonenko I, Ebeling C, Schwerdel C, Sidler C, Zeilhofer HU, Gerrits B, Muller D, Fritschy JM: Regulation of GABAergic synapse formation and plasticity by GSK-B-dependent phosphorylation of gephyrin. Proc Natl Acad Sci USA 2011 Jan 4;108(1):379-84 Wichtiger Hinweis: Diese Website wird in älteren Versionen von Netscape ohne graphische Elemente dargestellt. Die Funktionalität der Website ist aber trotzdem gewährleistet. Wenn Sie diese Website regelmässig benutzen, empfehlen wir Ihnen, auf Ihrem Computer einen aktuellen Browser zu installieren. Weitere Informationen finden Sie auf folgender Seite. 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