个人简介
招生专业
090801-水产养殖
070703-海洋生物学
招生方向
水产养殖生物病害防治
免疫学基础及应用
教育背景
1989-09--1994-07 中国科学院海洋研究所 硕博
1985-09--1989-07 山东大学 本科
工作简历
1994-07~现在, 中国科学院海洋研究所, 研究员
教授课程
水产养殖学
奖励信息
(1) 新型智能人机交互与融合计算关键技术研究与产业化应用, 一等奖, 省级, 2019
(2) 黄河三角洲产业领军人才, 市地级, 2019
(3) 虾蟹类颗粒饲料前熟化工艺开发与海水重要养殖生物病害发生和抗病力的基础研究应用, 一等奖, 市地级, 2008
(4) 中科院院地合作先进个人二等奖, , 院级, 2005
(5) 青岛市专业技术拔尖人才, , 市地级, 2004
(6) 功能性水产饲料开发, , 市地级, 2003
专利成果
( 1 ) 一种富含共轭亚油酸的保健甲鱼用添加剂及其制备方法, 发明, 2012, 第 1 作者, 专利号: ZL200810249527.2
( 2 ) 一种适用于饲料的转基因大豆检测试剂盒及检测方法, 发明, 2010, 第 2 作者, 专利号: ZL200710016892.4
( 3 ) 鲆鲽鱼类无公害饲料专用微量元素添加剂及制作工艺, 发明, 2010, 第 2 作者, 专利号: ZL200610046096.0
( 4 ) 一种抗菌肽及其构建和应用, 发明, 2011, 第 3 作者, 专利号: ZL200910019961.6
( 5 ) 一种草鱼或鲤鱼用肉质风味改良剂及其制备方法, 发明, 2011, 第 2 作者, 专利号: ZL200810249529.1
( 6 ) 一种低盐或淡水养殖凡纳滨对虾用品质改良剂及制备方法, 发明, 2011, 第 2 作者, 专利号: 201110341784.0
( 7 ) 鲆鲽鱼类无公害饲料专用免疫促长剂及其制作工艺, 发明, 2008, 第 3 作者, 专利号: ZL 200610046097.5
( 8 ) 一种鱼鳞胶原多肽及其制备方法, 发明, 2013, 第 5 作者, 专利号: ZL20111019660.9
( 9 ) 一种简便的转基因大豆检测试剂盒及检测方法, 发明, 2008, 第 2 作者, 专利号: ZL200810138673.8
( 10 ) 一种凡纳滨对虾无水保活运输技术, 发明, 2011, 第 1 作者, 专利号: 201110341736.1
( 11 ) 一种利用水稻作为生物反应器的蛋白渔药及其制备方法和应用, 发明, 2010, 第 3 作者, 专利号: 201010620652.7
( 12 ) 一种低盐或淡水养殖凡纳滨对虾用品质改良剂及制备方法, 发明, 2013, 第 2 作者, 专利号: ZL201110341784.0
( 13 ) 一种大黄鱼品质改良饲料及其投喂方法, 发明, 2014, 第 1 作者, 专利号: 201410739320.9
( 14 ) 一种利用水稻作为生物反应器的蛋白渔药及其制备方法和应用, 发明, 2014, 第 3 作者, 专利号: ZL201010620652
( 15 ) 一种三黄散超微粉及其制备方法, 发明, 2014, 第 3 作者, 专利号: 201410532879.4
( 16 ) 一种芪参散超微粉及其制备方法和应用, 发明, 2014, 第 3 作者, 专利号: 201410074881.1
( 17 ) 一种大鲵微颗粒饲料及其制备方法, 发明, 2013, 第 1 作者, 专利号: 201310689837.7
( 18 ) 一种大鲵成鱼饲料及制备方法, 发明, 2013, 第 2 作者, 专利号: 201310686505.3
( 19 ) 一种三文鱼专用饲料及其制备方法, 发明, 2014, 第 1 作者, 专利号: 201410739203.2
( 20 ) 一种新型对虾生物饲料及其应用, 发明, 2015, 第 3 作者, 专利号: 201310653238.X
( 21 ) 一种大鲵成鱼饲料及制备方法, 发明, 2014, 第 3 作者, 专利号: ZL201310686505.3
( 22 ) 一种大鲵微颗粒饲料及其制备方法, 发明, 2015, 第 1 作者, 专利号: ZL201310689837.7
( 23 ) 一种从海参加工废弃物中提取活性物质的方法, 发明, 2015, 第 3 作者, 专利号: ZL201310176271.8
( 24 ) 一种预防对虾白斑病的饲料添加剂及其制备方法, 发明, 2015, 第 3 作者, 专利号: ZL201310176271.8
( 25 ) 一种提高水产养殖动物免疫力的发酵中药制剂及其制备方法, 发明, 2016, 第 1 作者, 专利号: 201610548462.6
( 26 ) 高效净化养殖污水的解淀粉芽孢杆菌及其应用, 发明, 2016, 第 3 作者, 专利号: 201610910762.4
( 27 ) 一种海水养殖鲈鱼用品质改进剂及其制备方法, 发明, 2017, 第 2 作者, 专利号: 201710130757.6
( 28 ) 一种网箱养殖大黄鱼用肉质改进剂及其制备方法, 发明, 2018, 第 2 作者, 专利号: CN 108522898 A
( 29 ) 一种网箱养殖大黄鱼用体色改进剂及其制备方法, 发明, 2018, 第 2 作者, 专利号: CN 108813146 A
( 30 ) 一种便携式水质检测仪, 实用新型, 2019, 第 2 作者, 专利号: 201821329073.5
科研项目
( 1 ) 系列化水产养殖安全投入品开发, 主持, 研究所(学校), 2012-01--2014-12
( 2 ) 海洋水产病害防治关键技术研究, 主持, 国家级, 2012-01--2015-12
( 3 ) 安全绿色水产药物(中药与微生态)开发, 主持, 研究所(学校), 2013-01--2017-12
( 4 ) 胶原蛋白、鱼油等海洋生物制品制备技术开发, 主持, 研究所(学校), 2013-03--2016-03
( 5 ) 海水鱼新型生物饲料技术开发, 主持, 研究所(学校), 2014-04--2019-04
( 6 ) 凡纳滨对虾良种扩繁及高效生态养殖产业化, 参与, 部委级, 2014-05--2016-06
( 7 ) 海洋牧场实时监测和食品安全追溯体系开发与应用, 主持, 省级, 2015-04--2017-12
( 8 ) 水产品加工后贮运过程中品质控制与危害消减技术研究与示范, 主持, 国家级, 2015-04--2015-12
( 9 ) 抗对虾特定病原功能蛋白的开发与应用, 主持, 院级, 2016-03--2017-12
( 10 ) 南美白对虾功能性生物饲料的研发及产业化, 主持, 省级, 2016-06--2018-05
( 11 ) 对虾智能化养殖技术、装备开发与示范, 主持, 部委级, 2017-01--2018-12
( 12 ) 高效海洋生态牧场关键技术集成与示范, 参与, 部委级, 2017-01--2018-06
( 13 ) 环境友好型对虾工厂化养殖技术开发, 主持, 院级, 2018-07--2020-07
( 14 ) GT-6、GT-7对南美白对虾幼虾体质和成虾品质的影响实验, 主持, 院级, 2018-06--2019-06
( 15 ) 基于类胡萝卜素向虾蟹传递规律的海洋微藻高值转化科学基础, 参与, 国家级, 2018-01--2021-12
( 16 ) 基于大数据的智慧水产和信息追溯系统研发, 主持, 国家级, 2019-11--2022-12
( 17 ) 海水陆基精准养殖系统与环境智能调控技术, 主持, 省级, 2018-07--2020-12
近期论文
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(1) Understanding the roles of surface proteins in regulation of Lactobacillus pentosus HC-2 to immune response and bacterial diversity in midgut of Litopenaeus vannamei, FISH & SHELLFISH IMMUNOLOGY, 2019, 通讯作者
(2) A preliminary attempt to explore the potential functions of a tetraspanin gene (MmTSPAN) in the innate immunity of hard clam Meretrix meretrix: Sequence features and expression profiles, FISH & SHELLFISH IMMUNOLOGY, 2019, 通讯作者
(3) Comparative transcriptome analysis reveals the different roles between hepatopancreas and intestine of Litopenaeus vannamei in immune response to aflatoxin B1 (AFB1) challenge, Comparative Biochemistry and Physiology, Part C, 2019, 通讯作者
(4) Comparative study of beta-thymosin in two scallop species Argopecten irradians and Chlamys farreri, FISH & SHELLFISH IMMUNOLOGY, 2019, 通讯作者
(5) A novel LRR-only protein mediates bacterial proliferation in hemolymph through regulating expression of antimicrobial peptides in mollusk Chlamys farreri, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2019, 通讯作者
(6) Exploring the influence of the surface proteins on probiotic effects performed by Lactobacillus pentosus HC-2 using transcriptome analysis in Litopenaeus vannamei midgut, FISH & SHELLFISH IMMUNOLOGY, 2019, 通讯作者
(7) Litopenaeus vannamei fed diets with different replacement levels of fish meal by fish silage: A molecular approach on intestinal microbiota, Aquaculture nutrition, 2019, 通讯作者
(8) A global view of hepatopancreas and intestinal reveals the potential influencing mechanism of aflatoxin B1 on nutrition and metabolism in Litopenaeus vannamei, Aquaculture nutrition, 2019, 通讯作者
(9) The influence of surface proteins on the probiotic effects of Lactobacillus pentosus HC-2 in the Litopenaeus vannamei hepatopancreas, FISH & SHELLFISH IMMUNOLOGY, 2019, 通讯作者
(10) Exploration of the influence of surface proteins on the probiotic activity of Lactobacillus pentosus HC-2 in the Litopenaeus vannamei midgut via label-free quantitative proteomic analysis, FISH & SHELLFISH IMMUNOLOGY, 2019, 通讯作者
(11) Replacement of fishmeal by fermented soybean meal could enhance the growth performance but not significantly influence the intestinal microbiota of white shrimp Litopenaeus vannamei., Aquaculture, 2019, 通讯作者
(12) Adaptation of the white shrimp Litopenaeus vannamei to gradual changes to a low-pH environment, Ecotoxicol Environ Saf., 2018, 通讯作者
(13) Comparative sensitivity of the hepatopancreas and midgut in the white shrimp Litopenaeus vannamei to oxidative stress under cyclic serious/medium hypoxia, Aquaculture, 2018, 通讯作者
(14) Mechanistic target of rapamycin inhibition with rapamycin induces autophagy and correlative regulation in white shrimp (Litopenaeus vannamei), Aquaculture nutrition, 2018, 通讯作者
(15) Growth Performance, Digestive Enzymes, and TOR Signaling Pathway of Litopenaeus vannamei Are Not Significantly Affected by Dietary Protein Hydrolysates in Practical Conditions, FRONTIERS IN PHYSIOLOGY, 2018, 通讯作者
(16) Aflatoxin B1 (AFB1) induced dysregulation of intestinal microbiota and damage of antioxidant system in pacific white shrimp (Litopenaeus vannamei), Aquaculture, 2018, 通讯作者
(17) Analysis of the expression of metabolism-related genes and histopathology of the hepatopancreas of white shrimp Litopenaeus vannamei fed with aflatoxin B1, Aquaculture, 2018, 通讯作者
(18) Partial replacement of fishmeal by fermented soybean meal in diets for juvenile white shrimp (Litopenaeus vannamei), Aquaculture nutrition, 2018, 通讯作者
(19) Evaluation of biofloc meal as an ingredient in diets for white shrimp Litopenaeus vannamei under practical conditions: Effect on growth performance, digestive enzymes and TOR signaling pathway, Aquaculture, 2017, 通讯作者
(20) Effects of ammonia and nitrite accumulation on the survival and growth performance of white shrimp Litopenaeus vannamei, Invertebrate Survival Journal, 2017, 通讯作者
(21) Transcriptomic and morphological analyses of Litopenaeus vannamei intestinal barrier in response to Vibrio paraheamolyticus infection reveals immune response signatures and structural disruption, Fish Shellfish Immunol, 2017, 通讯作者
(22) A mitochondrial manganese superoxide dismutase involved in innate immunity is essential for the survival of Chlamys farreri, Fish & Shellfish Immunology, 2017, 通讯作者
(23) Transcriptome, antioxidant enzyme activity and histopathology analysis of hepatopancreas from the white shrimp Litopenaeusvannamei fed with aflatoxin B1(AFB1), Developmental & Comparative Immunology, 2017, 第 2 作者
(24) Effect of cyclic serious/medium hypoxia stress on the survival, growth performance and resistance against Vibrio parahemolyticus of white shrimp Litopenaeus vannamei, Invertebrate Survival Journal, 2017, 通讯作者
(25) Molecular characterization and transcriptional analysis of a crustacean heat shock protein 10 gene in shrimp Litopenaeus vannamei, ISJ-Invertebrate Survival Journal, 2017, 通讯作者
(26) A novel macrophage migration inhibitory factor gene from the Pacific white shrimp Litopenaeus vannamei (LvMIF2): comparative sequence and transcription analysis with LvMIF1, ISJ-Invertebrate Survival Journal, 2017, 通讯作者
(27) Sequence features, expression profiles and biochemical characteristics of a sigma class glutathione S-transferase gene (AiGSTσ) from bay scallop Argopecten irradians, ISJ-Invertebrate Survival Journal, 2017, 通讯作者
(28) The versatile functions of LRR-only proteins in mollusk Chlamys farreri, Developmental and comparative immunology, 2017, 第 2 作者
(29) 短期饲喂黄曲霉毒素B1对凡纳滨对虾肝胰腺抗氧化酶活性及基因表达的影响, 饲料工业, 2017, 通讯作者
(30) 黄曲霉毒素B1(AFB1)的短期投喂对凡纳滨对虾肠道黏膜屏障的影响, 水产学报, 2017, 通讯作者
(31) Bacterial Population and Histology of Intestines of Litopenaeus vannamei Fed Different Probiotics or Probiotic Supernatant, J Microbiol. Biotechn, 2016, 通讯作者
(32) Gut bacterial diversity of farmed sea cucumbers Apostichopus japonicus with different growth rates, Microbiology, 2016, 通讯作者
(33) Interaction between Lactobacillus pentosus HC-2 and Vibrio parahaemolyticus E1 in Litopeneaus vannamei in vivo and in vitro, Aquaculture, 2016, 通讯作者
(34) Effects of lactic acid bacteria and the corresponding supernatant on the survival, growth performance, immune response and disease resistance of Litopenaeus vannamei, Aquaculture, 2016, 第 2 作者
(35) 饲料中添加两株乳酸菌及其发酵上清液对凡纳滨对虾消化酶活性的影响, 海洋科学, 2016, 第 2 作者
(36) Low temperature stress on the hematological parameters and HSP gene expression in the turbot Scophthalmus maximus, Chinese Journal of Oceanology and Limnology, 2016, 通讯作者
(37) 凡纳滨对虾TOR 蛋白下游信号传导因子eIF4E2 和eIF4E1A基因克隆与功能分析, 海洋科学, 2016, 第 2 作者
(38) Target of rapamycin (TOR) in Fenneropenaeus chinensis:cDNA cloning, characterization, tissue expression and response to amino acids, Aquaculture Nutrition, 2015, 通讯作者
(39) A new method to evaluate the effects of bacterial dosage, infection route and Vibrio strain in experimental challenges of Litopenaeus vannamei, based on the Cox proportional hazard model, Fish & shellfish immunology, 2015, 通讯作者
(40) The transcriptomic response to copper exposure in the digestive gland of Japanese scallops (Mizuhopecten yessoensis), Fish & Shellfish Immunology, 2015, 通讯作者
(41) Low temperature stress on the hematological parameters and HSP gene expression in the turbot Scophthalmus maximus, Chinese Journal of Oceanology and Limnology, 2015, 通讯作者
(42) Effects of lactic acid bacteria and the corresponding supernatant on the survival, growth performance, immune response and disease resistance of Litopeaeus vannamei, Aquaculture, 2015, 通讯作者
(43) 生物饲料对凡纳滨对虾生长、免疫及消化功能的影响, 海洋科学, 2015, 通讯作者
(44) 哈氏弧菌浸浴后凡纳滨对虾肠道组织病理变化及转录水平的免疫应答, 水产学报, 2015, 通讯作者
(45) Molecular cloning of hemocyanin cDNA from Fenneropenaeus chinensis and antimicrobial analysis of two C-terminal fragments, Marine Biotechnology, 2014, 通讯作者
(46) Rice bran expressing a shrimp antimicrobial peptide confers delayed spoilage of fish feed and resistance of tilapia to Aeromonas hydrophila, Journal of the World Aquaculture Society, 2014, 通讯作者
(47) The transcriptomic response to copper exposure by the gill tissue of Japanese scallops (Mizuhopecten yessoensis) using deep-sequencing technology, Fish Shellfish Immun., 2014, 通讯作者
(48) Effect of dietary supplementation of vitamin C on growth, reactive oxygen species, and antioxidant enzyme activity of Apostichopus japonicus (Selenka) juveniles exposed to nitrite, Chinese Journal of Oceanology and Limnology, 2014, 通讯作者
(49) Effect of dietary vitamin E supplementation on oxidative stress response of acute nitrite exposure in sea cucumber (Apostichopus japonicus Selenka) juveniles, Journal of Animal and Veterinary Advances, 2014, 通讯作者
(50) 连续降温对大菱鲆成鱼代谢机能的影响, 海洋科学, 2014, 通讯作者
(51) Cloning of the cDNA encoding adenosine 5-monophosphate deaminase 1 and its mRNA expression in Japanese flounder Paralichthys olivaceus, Chinese Journal of Oceanology and Limnology, 2013, 通讯作者
(52) Purification and identification of a clotting protein from the hemolymph of Chinese shrimp ( Fenneropenaeus chinensis), Journal of Ocean University of China, 2013, 通讯作者
(53) Peptidomic analysis of Chinese shrimp ( Fenneropenaeusn chinensis ) hemolymph by magnetic bead-based MALDITOFMS, Chinese Journal of Oceanology and Limnology, 2013, 通讯作者
(54) Cadmium Bioaccumulation and its Effect on Antioxidant Defense System of Japanese Scallop Mizuhopecten yessoensis, Journal of Animal and Veterinary Advances, 2013, 通讯作者
(55) De Novo Characterization of Japanese Scallop Mizuhopecten yessoensis Transcriptome and Analysis of Its Gene Expression following Cadmium Exposure, PLOS ONE, 2013, 通讯作者
(56) Statistical optimization of the medium composition and culture conditions for the production of recombinant anti-lipopolysaccharide factor of Eriocheir sinensis in Escherichia coli, Chinese Journal of Oceanology and Limnology, 2011, 通讯作者
(57) 中国明对虾血浆蛋白质组双向电泳技术的建立与主要高丰度蛋白点的质谱鉴定, 水产学报, 2011, 通讯作者
(58) 大肠杆菌表达抗脂多糖因子的发酵条件优化, 中国农业科技导报, 2011, 通讯作者
(59) PCR-DGGE analysis of intestinal bacteria and effect of Bacillus spp. on intestinal microbial diversity in kuruma shrimp (Marsupenaeus japonicus), Chinese Journal of Oceanology and Limnology, 2010, 通讯作者
(60) 饲料中添加重组抗菌肽对吉富罗非鱼生长性能及免疫力的影响, 中国水产科学, 2010, 通讯作者
(61) 中国明对虾血浆蛋白质组学研究中高丰度蛋白的超速离心去除技术, 中国水产科学, 2010, 通讯作者
(62) 中国明对虾(Fenneropenaeus chinensis)肠道微生物区系组成的分子分析, 饲料工业, 2010, 通讯作者
(63) 中国明对虾酚氧化酶原基因CDNA的克隆与表达特征, 水产学报, 2010, 通讯作者
(64) 中国明对虾血蓝蛋白的基因cDNA克隆及序列分析, 渔业科学进展, 2010, 通讯作者
(65) 中国明对虾TOR基因的克隆及精氨酸、亮氨酸对其表达的影响, 海洋科学, 2010, 通讯作者
(66) 适于集约化水产养殖的固定化微生物技术的初步研究, 海洋科学, 2010, 第 1 作者
(67) Sensitive and Rapid Detection of Genetic Modified Soybean (Roundup Ready) by Loop-Mediated Isothermal Amplification, Bioscience Biotechnology, and Biochemistry, 2009, 通讯作者
(68) 进口转基因大豆(Roundup Ready)对吉富罗非鱼生长和生理的影响, 粮食与饲料工业, 2009, 通讯作者
(69) 用于养殖环境调控的微生物制剂评价方法的研究, 海洋科学, 2009, 第 1 作者
(70) Purification and characterization of a natural lectin from the plasma of the shrimp Fenneropenaeus chinensis, Fish Shellfish Immunol., 2008, 通讯作者
(71) 应用PCR-DGGE分析南美白对虾肠道微生物多样性, 饲料工业, 2008, 通讯作者
(72) Purification and characterization of a natural Lectin from the serum of the shrimp Litopenaeus vannamei, Fish Shellfish Immunol, 2007, 通讯作者
(73) 奥尼亚罗非鱼生长性能与血液生理生化指标相关性的研究, 中国水产科学, 2007, 通讯作者