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招生专业 070703-海洋生物学 招生方向 深海微生物生命过程认知及活性物质发掘利用 教育背景 2006-12--2013-12 美国加州大学伯克利分校 博士后 2002-09--2006-07 中国科学院微生物研究所 博士 1999-09--2002-07 山东省农业大学 硕士 1995-09--1999-07 山东省农业大学 学士 工作简历 2014-01~现在, 中国科学院海洋研究所, 研究员 专利成果 ( 1 ) 一种嗜盐菌素及其免疫蛋白和它们的编码基因与应用, 发明, 2006, 第 3 作者, 专利号: CN 1837233A ( 2 ) Methods and compositions for inhibiting Hepatitis C Virus replication. , 发明, 2010, 第 1 作者, 专利号: 2010/081095 ( 3 ) 一种极端嗜盐古菌质粒及其衍生质粒载体, 发明, 2005, 第 2 作者, 专利号: CN 1712533A ( 4 ) 表达极端嗜盐古菌紫膜蛋白突变体的载体及工程菌, 发明, 2006, 第 5 作者, 专利号: CN 1746303A 科研项目 ( 1 ) 海洋微生物活性物质的发掘和利用, 主持, 部委级, 2014-01--2016-12 ( 2 ) 抑制丙肝病毒复制的海洋微生物活性物质的筛选及分子机理研究, 主持, 国家级, 2015-01--2018-12 ( 3 ) 海洋微生物生命过程及活性物质发掘利用, 主持, 部委级, 2015-07--2018-12 ( 4 ) 重要海洋微生物活性物质的合成调控、生理 功能及作用机理研究, 主持, 国家级, 2015-01--2018-12 ( 5 ) 海洋微生物活性物质的发掘和利用, 主持, 省级, 2016-06--2019-06 ( 6 ) 海洋微生物在重金属去除中的作用机制及应用, 主持, 省级, 2017-01--2021-12 ( 7 ) 新型深海微生物酶/胞外多糖应用潜力评价与应用示范, 主持, 研究所(学校), 2018-01--2020-12 ( 8 ) 海洋微生物活性物质的发掘利用, 主持, 研究所(学校), 2018-01--2020-12 ( 9 ) 深海冷泉微生物代谢产物资源挖掘与药用潜力评估, 主持, 国家级, 2018-07--2021-12 ( 10 ) 板块俯冲体系下特殊生命过程, 主持, 部委级, 2018-09--2023-08 参与会议 (1)海洋微生物在环境修复领域中的资源发掘及应用 中国微生物学会第八届地质微生物学学术研讨会 2019-06-14 (2)海洋微生物生命活动认知及活性物质发掘利用 第八届全国微生物遗传学研讨会 2018-07-29 (3)Biosynthesis and action mechanism insights of marine polysaccharide with antibiofilm or anticancer activity 第十一届世界糖基转移酶学术会议 2018-06-21 (4)The screening and mechanism studies of anti-hepatoma cocktail 第十三届海洋药物学术年会暨2017 国际海洋药物研讨会 2017-11-07 (5)海洋微生物活性物质的发掘和利用:从浅海到深海 鳌山论坛——“深海生态系统:极端环境与生命过程” 2017-08-31 (6)Genomic and transcriptomic insights into the calcium carbonate biomineralization by marine actinobacterium Brevibacterium lines BS258 2017-04-27 (7)海洋微生物活性物质的发掘和利用 中国海洋湖沼学会年会 2016-11-08 (8)海洋微生物多糖EPS273的生物合成及其抑制铜绿假单胞菌生物膜形成的作用机制研究 中国微生物遗传学年会 2016-08-05 (9)真核生物翻译起始因子eIF3调控丙肝病毒复制的分子机制 全球华人遗传学大会 2014-10-31 (10)海洋生物农药在植物保护中的应用 青岛农业大学植保大讲堂 2014-10-17 (11)Screening and molecular mechanism studies of marine microbial natural products inhibiting replication of Hepatitis C Virus 全球海洋生物多样性国际会议 2014-10-08 (12)Control the hepatitis c virus by eIF3 Chaomin Sun, Jamie Cate 2012-09-06

研究领域

深海微生物生命过程认知及活性物质发掘利用

近期论文

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(1) A novel bacterial thiosulfate oxidation pathway provides a new clue about the formation of zero-valent sulfur in deep sea, ISME J, 2020, 通讯作者 (2) Sorafenib kills Huh7.5 liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via ATP-AMPK-mTOR-SREBP1 signaling pathway, FASEB Journal, 2019, 通讯作者 (3) Marine bacterial polysaccharide EPS11 inhibits cancer cell growth and metastasis via blocking cell adhesion and attenuating filiform structure formation, Marine Drugs, 2019, 通讯作者 (4) Characterization of antifungal lipopeptide biosurfactants produced by marine bacterium Bacillus sp. CS30, Marine Drugs, 2019, 通讯作者 (5) Marine bacterial polysaccharide EPS11 inhibits cancer cell growth via blocking cell adhesion and stimulating anoikis, Marine Drugs, 2018, 通讯作者 (6) Genetic and physiological adaptations of marine bacterium Pseudomonas stutzeri 273 to mercury stress, Frontiers in Microbiology, 2018, 通讯作者 (7) The natural compound GL22, isolated from Ganoderma mushrooms, suppresses tumor growth by altering lipid metabolism and triggering cell death, Cell Death and Disease, 2018, 通讯作者 (8) Cyclic lipopeptides fengycins from marine bacterium Bacillus subtilis kill plant pathogenic fungus Magnaporthe grisea by inducing reactive oxygen species production and chromatin condensation, Applied and Environmental Microbiology, 2018, 通讯作者 (9) Identification and analysis of novel inhibitors against NS3 helicase and NS5B RNA-dependent RNA polymerase from hepatitis C virus 1b (Con1), Frontiers in Microbiology, 2017, 通讯作者 (10) The structure-activity relationship between polysaccharides from Sargassum thunbergii and anti-tumor activity, International Journal of Biological Macromolecules, 2017, 通讯作者 (11) Mansouramycin C induces reactive oxygen species and tumor cell apoptosis through opening of the mitochondrial permeability transition pore, Oncotarget, 2017, 通讯作者 (12) Genome sequence of Pseudomonas stutzeri 273 and identification of the exopolysaccharide EPS273 biosynthesis locus, Marine Drugs, 2017, 通讯作者 (13) Establishment and application of a high throughput screening system targeting the interaction between HCV internal ribosome entry site and human eukaryotic translation initiation factor 3, Frontiers in Microbiology, 2017, 通讯作者 (14) Pumilacidin-like lipopeptides derived from marine bacterium Bacillus sp. suppress the motility of Vibrio alginolyticus., Applied and Environmental Microbiology, 2017, 通讯作者 (15) Genomic and transcriptomic insights into calcium carbonate biomineralization by marine actinobacterium Brevibacterium linens BS258, Frontiers in Microbiology, 2017, 通讯作者 (16) Polysaccharides from Sargassum thunbergii: Monthly variations and anti-complement and anti-tumour activities, International Journal of Biological Macromolecules, 2017, 通讯作者 (17) Antagonistic activity and mode of action of phenazine-1-carboxylic acid, produced by marine bacterium Pseudomonas aeruginosa PA31x, against Vibrio anguillarum In vitro and in a Zebrafish In vivo model, Frontiers in Microbiology, 2017, 通讯作者 (18) The inhibition and resistance mechanisms of actinonin, isolated from marine Streptomyces sp. NHF165, against Vibrio anguillarum, Frontiers in Microbiology, 2016, 通讯作者 (19) Amy63, a novel type of marine bacterial multifunctional enzyme possessing amylase, agarase and carrageenase activities., Scientific Reports, 2016, 通讯作者 (20) Pelagibacterium lixinzhangensis sp. nov., a Novel Member of the Genus Pelagibacterium., Current Microbiology, 2016, 通讯作者 (21) Antibiofilm and anti-infection of a marine bacterial exopolysaccharide against Pseudomonas aeruginosa., Frontiers in Microbiology, 2016, 通讯作者 (22) A novel polysaccharide from Sargassum integerrimum induces apoptosis in A549 cells and prevents angiogensis in vitro and in vivo, Scientific Reports, 2016, 通讯作者 (23) Purification and biochemical characterization of an alkaline protease from marine bacteria Pseudoalteromonas sp. 129-1, J. Basic Microbiol, 2015, 通讯作者 (24) Algoriella xinjiangensis gen. nov., sp. nov., a new psychrotolerant bacterium of the family Flavobacteriaceae, Antonie van Leeuwenhoek, 2015, 通讯作者 (25) Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation., Nucleic Acids Research, 2013, 第 1 作者 (26) Architecture of human translation initiation factor., Structure, 2013, 第 1 作者 (27) Functional reconstitution of human translation initiation factor eIF3. , PNAS, 2011, 第 1 作者 (28) C virus core-derived peptides inhibit genotype 1b viral genome replication via interaction with DDX3X., PLOS One, 2010, 第 1 作者 (29) Construction and application of a novel shuttle expression vector based on haloarchaeal plasmid pSCM201., Acta of Microbiology, 2009, 第 2 作者 (30) The Helix-Loop-Helix Motif at the N-terminal of HalI Is Essential for Its Immunity Function against Halocin C8. , J Bacteriol., 2008, 第 2 作者 (31) Precise Determination, Cross-Recognition and Functional Analysis of the Double-Strand Origins of the Rolling Circle Replication Plasmids in Haloarchaea., J Bacteriol., 2008, 第 3 作者 (32) Genetic analysis of a novel plasmid pZMX101 from Halorubrum saccharovorum: determination of the minimal replicon and comparison with the related haloarchaeal plasmid pSCM201. , FEMS Microbiol Lett. , 2007, 第 3 作者 (33) Unidirectional theta replication of pSCM201, a novel structurally stable plasmid from extremely halophilic archaea, J Bacteriol, 2006, 第 1 作者 (34) A single gene directs both production and immunity of halocin C8 in a haloarchaeal strain AS7092., Molecular Microbiology, 2005, 第 1 作者 (35) Expression of SARS-coronavirus nucleocapsid protein in Escherichia coli and Lactococcus lactis for serodiagnosis and mucosal vaccination., Appl Microbiol Biotechnol, 2005, 第 4 作者 (36) Complete sequence and molecular characterization of pNB101, a rolling-circle replicating plasmid from the haloalkaliphilic archaeon Natronobacterium sp. strain AS7091., Extremophiles, 2004, 第 3 作者 (37) Construction of a novel shuttle vector based on an RCR-plasmid from a haloalkaliphilic archaeon and transformation into other haloarchaea. , Biotechnol Lett, 2003, 第 3 作者 (38) on the fertilizer efficiency of tobacco fungicide T. virid and its colonization on tobacco leaf and root. , Acta Tabacaria Sinica, 2002, 第 3 作者

学术兼职

2019-06-01-今,中国微生物遗传学会, 副主任 2017-01-01-2021-12-31,海洋湖沼学会药学分会, 秘书长

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