刘保忠 - 中国科学院大学 - 现代农业科学学院

个人简介

招生专业 070703-海洋生物学招生方向繁殖、发育与调控技术，遗传学与遗传工程教育背景 1997-09--2003-06 中国科学院海洋研究所博士研究生/理学博士 1989-09--1992-06 中国科学院海洋研究所硕士研究生/理学硕士 1983-09--1987-06 中国海洋大学学生/理学学士工作简历 2004-10~2005-04,香港科技大学, 访问学者 2004-01~2004-04,South Australian Aquatic Sciences Centre, SARDI, 访问学者 1987-07~现在, 中国科学院海洋研究所, 助理研究员、副研究员、研究员教授课程特色海水养殖学发育生物学奖励信息（1）重要滩涂贝类良种培育技术体系创建与应用, 二等奖, 省级, 2017 （2）海水生物活饵料和全熟膨化饲料的, 二等奖, 国家级, 2006 专利成果（ 1 ）一种滩涂埋栖性贝类生物净化方法, 发明, 2006, 第 1 作者, 专利号: ZL 03 1 34147.0 （ 2 ）滩涂贝类工厂化育苗高效采苗方法及所用采苗器, 发明, 2006, 第 2 作者, 专利号: ZL 2003 1 0105038.7 （ 3 ）一种基于有机质的海产双壳贝类幼虫变态诱导剂及其应用, 发明, 2004, 第 1 作者, 专利号: ZL 03 1 10959.4 （ 4 ）文蛤溶菌酶基因及其体外重组表达和应用, 发明, 2012, 第 1 作者, 专利号: ZL 201010201257.5 （ 5 ）文蛤微卫星标记的检测方法, 发明, 2014, 第 1 作者, 专利号: 201210112746.2 （ 6 ）文蛤DNA结合抑制因子mmID2基因及其编码蛋白和应用, 发明, 2013, 第 4 作者, 专利号: 201210517841.0 （ 7 ）一种适用于文蛤家系鉴定的微卫星标记方法, 发明, 2014, 第 3 作者, 专利号: ZL201210112325.X （ 8 ）文蛤巨噬细胞迁移抑制因子基因及其编码蛋白和应用, 发明, 2015, 第 1 作者, 专利号: 2015105779666 （ 9 ）一种对文蛤混合家系进行遗传力估计的方法, 发明, 2015, 第 2 作者, 专利号: 2015105782885 （ 10 ）文蛤多巴脱羧酶基因及其编码蛋白和应用, 发明, 2017, 第 2 作者, 专利号: 201710032506.4 （ 11 ）一种对文蛤混合家系进行遗传力估计的方法, 发明, 2018, 第 2 作者, 专利号: 201510578288.5 （ 12 ）文蛤DNA结合抑制因子mmID2基因及其编码蛋白和应用, 发明, 2016, 第 4 作者, 专利号: 201210517841.0 发表著作（1）中华人民共和国国家标准《海湾扇贝》（GB/T 21443-2008）, Bay scallop, 中国标准出版社, 2008-12, 第 1 作者科研项目（ 1 ）主要养殖双壳贝类良种培育, 主持, 国家级, 2012-01--2015-12 （ 2 ） TGF-β信号通路在长牡蛎早期胚胎背部化决定及贝壳发生中的功能研究, 主持, 国家级, 2015-01--2018-12 （ 3 ）国家现代农业产业技术体系(贝类体系): 蛤蚶蛏种质资源与品种改良, 主持, 国家级, 2017-01--2020-12 （ 4 ）海洋动物个体发育与系统演化遗传基础, 主持, 省级, 2018-07--2020-12 参与会议（1）DEVELOPMENT OF SNP MARKERS ASSOCIATED WITH GROWTH AND RESISTANCE TRAITS IN THE CLAM Meretrix meretrix Liu Baozhong et al. 2014-06-07

近期论文

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（1） Identification of three cell populations from the shell gland of a bivalve mollusc., Development Genes and Evolution., 2020, 通讯作者（2） TAF5L functions as transcriptional coactivator of MITF involved in the immune response of the clam Meretrix petechialis., Fish & Shellfish Immunology, 2020, 通讯作者（3） Dorsoventral decoupling of Hox gene expression underpins the diversification of molluscs., PNAS, 2020, 通讯作者（4） Identification of a laccase gene involved in the shell periostracal tanning of the clam Meretrix petechialis., Aquatic Biology, 2019, 通讯作者（5） Dynamic immune and metabolism response of clam Meretrix petechialis to Vibrio challenge revealed by a time series of transcriptome analysis., Fish & Shellfish Immunology, 2019, 通讯作者（6） MITF regulates downstream genes in response to Vibrio parahaemolyticus infection in the clam Meretrix petechialis., Frontiers in Immunology, 2019, 通讯作者（7） Integrated transcriptomic and proteomic analyses reveal potential mechanisms linking thermal stress and depressed disease resistance in the turbot Scophthalmus maximus., Scientific Reports., 2018, 通讯作者（8） An investigation of oyster TGF-β receptor genes and their potential roles in early development, Gene, 2018, 通讯作者（9） Integrating the Vibrio-resistance phenotype and gene expression data for discovery of markers used for resistance evaluation in the clam Meretrix petechialis, Aquaculture, 2018, 通讯作者（10） Transcriptome profiles of the clam Meretrix petechialis hepatopancreas in response to Vibrio infection., Fish & Shellfish Immunology, 2017, 通讯作者（11） Expression patterns indicate that BMP2/4 and Chordin, not BMP5-8 and Gremlin, mediate dorsal-ventral patterning in the mollusk Crassostrea gigas., Development Genes and Evolution., 2017, 通讯作者（12） A comparative proteomic analysis reveals important proteins for the fertilization and early embryonic development of the oyster Crassostrea gigas., PROTEOMICS, 2017, 通讯作者（13） Mining and identification of SNP markers associated with growth traits in the clam Meretrix meretrix,, Aquaculture International., 2017, 通讯作者（14） A SoxC gene related to larval shell development and co-expression analysis of different shell-formation genes in early larvae of oyster, Development Genes and Evolution, 2017, 通讯作者（15） Identification of an MITF gene and its polymorphisms associated with the Vibrio resistance trait in the clam Meretrix petechialis, Fish & Shellfish Immunology, 2017, 通讯作者（16） Assessment of housekeeping genes as internal references in quantitative expression analysis during early development of oyster., Genes & Genetic Systems, 2016, 通讯作者（17） Characterization and expression of a novel caspase gene: evidence of the expansion of caspases in Crassostrea gigas., Comparative Biochemistry and Physiology, Part B., 2016, 通讯作者（18） The polymorphisms of a MIF gene and their association with Vibrio resistance in the clam Meretrix meretrix., Developmental & Comparative Immunology, 2016, 通讯作者（19） The impact of selection on population genetic structure in the clam Meretrix petechialis revealed by microsatellite markers., Genetica., 2016, 通讯作者（20） Identification of the MmeHairy gene and expression analysis affected by two SNPs in the 3′-untranslated region in the clam Meretrix meretrix., Fish & Shellfish Immunology, 2016, 通讯作者（21） A GATA2/3 gene potentially involved in larval shell formation of the Pacific oyster Crassostrea gigas., Development Genes and Evolution, 2015, 通讯作者（22） A label-free proteomic analysis on competent larvae and juveniles of the Pacific oyster Crassostrea gigas., PLoS ONE, 2015, 通讯作者（23） Identification of a Serum amyloid A gene and the association of SNPs with Vibrio-resistance and growth traits in the clam Meretrix meretrix, Fish and Shellfish Immunology, 2015, 通讯作者（24） Transcriptome analysis of shell-color related genes in the clam Meretrix meretrix. , Marine biotechnology, 2015, 通讯作者（25） Development of Vibrio spp. infection resistance related SNP markers using Multiplex SNaPshot genotyping method in the clam Meretrix meretrix., Fish and Shellfish Immunology, 2015, 通讯作者（26） Characterization of a long-chain fatty acid-CoA ligase 1 gene and association between its SNPs and growth traits in the clam Meretrix meretrix , Gene, 2015, 通讯作者（27） The role of Cu/Zn-SOD and Mn-SOD in the immune response to oxidative stress and pathogen challenge in the clam Meretrix meretrix. , Fish and Shellfish Immunology, 2015, 通讯作者（28） Multiple ferritin subunit genes of the Pacific oyster Crassostrea gigas and their distinct expression patterns during early development, Gene , 2014, 通讯作者（29） Cloning and expression patterns of two smad genes during embryonic development and shell formation of the Pacific oyster Crassostrea gigas , Chinese Journal of Oceanology and Limnology, 2014, 通讯作者（30） Assessment of parental contribution and effective population size to 3×3 diallel cross of the clam Meretrix meretrix. , Chinese Journal of Oceanology and Limnology, 2014, 通讯作者（31） An EGFR gene of the Pacific oyster Crassostrea gigas functions in wound healing and promotes cell proliferation. , Molecular Biology Reports, 2014, 通讯作者（32） Expression patterns of an i-type lysozyme in the clam Meretrix meretrix along with larval development, Developmental and Comparative Immunology, 2013, 通讯作者（33） The role of catalase in the immune response to oxidative stress and pathogen challenge in the clam Meretrix meretrix , Fish and Shellfish Immunology, 2013, 通讯作者（34） Three vibrio-resistance related EST-SSR markers revealed by selective genotyping in the clam Meretrix meretrix., Fish and Shellfish Immunology, 2013, 通讯作者（35） Identification of a tyrosinase gene potentially involved in early larval shell biogenesis of the Pacific oyster Crassostrea gigas., Development Genes and Evolution, 2013, 通讯作者（36） Growth performance of the clam Meretrix meretrix breeding-selection populations cultured in different conditions , Acta Oceanologica Sinica, 2013, 通讯作者（37） Three EST-SSR markers associated with QTL for the growth of the clam Meretrix meretrix revealed by selective genotyping , Marine biotechnology, 2013, 通讯作者（38） The potential roles of a laminin receptor in adhesion and apoptosis of cells of the marine bivalve Meretrix meretrix, PLoS ONE, 2012, 通讯作者（39） Identification of differentially expressed proteins involved in the early larval development of the Pacific oyster Crassostrea gigas, Journal of Proteomics, 2012, 通讯作者（40） Transcriptomic analysis of the clam Meretrix meretrix on different larval stages, Marine Biotechnology, 2012, 通讯作者（41） Genetic diversity of the sulfotransferase-like gene and one nonsynonymous SNP associated with growth traits of clam, Meretrix meretrix. , Molecular Biology Reports, 2012, 通讯作者（42） RNAi assay in primary cells：a new method for gene function analysis in marine bivalve, Molecular Biology Reports, 2012, 通讯作者（43） Single nucleotide polymorphisms in i-type lysozyme gene and their correlation with vibrio-resistance and growth of clam Meretrix meretrix based on the selected resistance stocks, Fish and Shellfish Immunology, 2012, 通讯作者（44） Isolation and characterization of a virulent Vibrio sp. bacterium from clams (Meretrix meretrix) with mass mortality, Journal of Invertebrate Pathology, 2011, 通讯作者（45） An i-type lysozyme from the Asiatic hard clam Meretrix meretrix potentially functioning in host immunity, Fish and Shellfish Immunology , 2011, 通讯作者（46） Cloning and characterization of a hsp70 gene from Asiatic hard clam Meretrix meretrix which is involved in the immune response against bacterial infection, Fish and Shellfish Immunology, 2011, 通讯作者（47） Microsatellite-based genetic and growth analysis for a diallel mating design of two stocks of the clam, Meretrix meretrix , Aquaculture Research, 2011, 通讯作者（48） , Potential role of cathepsin B in the embryonic and larval development of clam Meretrix meretrix, Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 2011, 通讯作者（49） An effective method for parentage determination of clam (Meretrix meretrix) based on SSR and COI markers, Aquaculture, 2011, 通讯作者（50） Recombinant expression, characterization and expressional analysis of clam Meretrix meretrix cathepsin B, an enzyme involved in nutrient digestion, Molecular Biology Reports, 2011, 通讯作者（51） Molecular characterization of a glutathione peroxidase gene and its expression in the selected Vibrio-resistant population of the clam Meretrix meretrix , Fish and Shellfish Immunology, 2011, 通讯作者（52） Estimation of genetic parameters for growth traits in cultured clam Meretrix meretrix (Bivalvia: Veneridae) using Bayesian method based on Gibbs sampling, Aquaculture Research, 2011, 通讯作者（53） Mining of EST-SSR markers from clam Meretrix meretrix larvae by 454 shotgun transcriptome. , Genes and Genetic Systems, 2011, 通讯作者（54） Complete mtDNA of the Meretrix lamarckii (Bivalvia: Veneridae) and molecular identification of suspected M. lamarckii based on the whole mitochondrial genome, Marine Genomics, 2011, 通讯作者（55） , Complete mtDNA of Meretrix lusoria (Bivalvia: Veneridae) reveals the presence of an atp8 gene, length variation and heteroplasmy in the control region., Comparative Biochemistry and Physiology- Part D, 2010, 通讯作者（56） Identification and characterization of the pathogenic effect of a Vibrio parahaemolyticus-related bacterium isolated from clam Meretrix meretrix with mass mortality. , Journal of Invertebrate Pathology, 2010, 通讯作者（57） Physiological and Immune Responses of Zhikong Scallop Chlamys farreri to the Acute Viral Necrobiotic Virus Infection. , Fish and Shellfish Immunology, 2010, 通讯作者（58） Analysis of metallotionein expression and antioxidant enzyme activities in Meretrix meretrix larvae under sublethal cadmium exposure, Aquat.Toxicol, 2010, 通讯作者

学术兼职

2019-10-01-今,《海洋科学》, 副主编 2014-01-01-今,水产学报, 编委