个人简介
教育背景
08/1998-07/2001 哲学/医学博士
专业：细胞和分子生物学， 北京大学医学部（原北京医科大学）
导师：钟南山
中国工程院院士,
09/1995-07/1998 内科学硕士
导师： 何权赢教授，北京大学附属人民医院呼吸科
09/1986-07/1991 山东医科大学医学系学士
专业背景
08/2012- 高级研究员，香雪制药公司 大分子项目
07/2008- 07/2012 研究科学家，基因治疗中心，美国国立儿童医院研究所 / 综合癌症中心
01/2006 -06/2008 研究科学家, 美国俄亥俄州立大学医学中心，戴维斯心肺研究所
05/2004-12/2005 博士后研究员, 美国俄亥俄州立大学医学中心, 戴维斯心肺研究所
11/2001-04/2004 博士后研究员，美国弗罗里达大学医学院
导师：Edward R. Block 大学杰出教授， 医学系主任
10/1991-08/1995 医师，山东省立医院内科
近期论文
查看导师新发文章
（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
1. Peng Z, Weber C, Han Z, Scott JR, Chan M, Lin HJ. Dichotomy effects of Akt signaling in
breast cancer. Mol cancer. 2012 Aug 24;11(1):61. Epub ahead of print
2. Han Z, L Druhan, A Cardounel, L Chicoine. Regulation of endothelial nitric oxide production by
protein methyltransferase's. FASEB J. 2011(published) note: conference article
3. Natale E, Han Z, Slutzky JL, Chicoine LG. Resveratrol reverses both thromboxane A2 receptor and
non receptor (K+) mediated pulmonary vasoconstriction. FASEB J 2009 (published) note:
conference article
4. Han Z, Pope AJ, Chicoine LG & Cardounel AJ. Increased ADMA/protein methylation modulates nitric
oxide generation in hypoxic human lung microvascular endothelial cells. FASEB J 2009 (published)
note: conference article
5. Han Z, Varadharaj S., Jones C.I., Zweier JL, Alevriadou BR. Mitochondria-derived reactive oxygen
species mediate heme oxygenase-1 expression in sheared endothelial cells. J Pharmacol Exp Ther. 2009
Apr;329(1):94-101. Epub 2 009 Jan 8.
6. Han Z*, Jones C.I*. Alevriadou BR and Zweier JL Endothelial cell respiration is affected by the
oxygen tension during shear exposure: role of mitochondria peroxynitrite. Am. J. Physiol. (cell
physiology), 2008 Jul; 295(1):C180-91. * contribute equally
Email: hanzhaosheng@gmail.com; hanzhsh@xphcn.com
Phone: (020)-22211900(o); 18988918152 (c)
7. Han, Z, Chen YR, Jones CI, Meenakshisundaram G, Zweier JL., Alevriadou BR Shear-induced
reactive nitrogen species inhibit mitochondrial respiratory complex activities in cultured vascular
endothelial cells. Am. J. Physiol. (cell physiology). 2007 Mar; 292(3): C1103-12
8. Jones CI, Zhu H, Han Z, Li Y, Alevriadou BR. Regulation of antioxidants and phase 2 enzymes by
shear-induced reactive oxygen species in endothelial cells. Ann. Biomed Eng. 2007 May; 35(5)683-93.
9. Han Z*, Cui Z*, Li Z, Hu H, Patel J.M., Antony V., Block E.R., Su Y. Involvement of calpaincalpastatin
in cigarette smoke-induced inhibition of lung endothelial NOS. Am. J. Respir Cell Mol
Biol. 2005 Nov; 33(5):513-20, * contribute equally
10. Han Z, Su Y, Block ER. Involvement of acetylated histone 3 in cigarette extract-induced inhibition
of nitric oxide synthase gene transcription in pulmonary artery endotelial cells. Am J of Respir and
Crit Care Med. 2004Apr; 169(7):A395
11. Xu Y, Wen S, Han Z, Zhong NS. The role of endotelial -1 in initial phase of airway inflammation.
Am J of Respir and Crit Care Med. 2002 Apr; 165(8):A731
12. Su Y, Cao, W, Han Z, Block ER. Cigarette smoke extract inhibits angiogenesis of pulmonary artery
endothelial cells: The role of calpain. Am J Physiol Lung Cell Mol Physiol 2004 Oct;287(4):L794-800
13. Han Z, Xu J, and Zhong NS. The expression of matrix metalloproteinase-9 within the airways in
asthma. Respiratory Medicine 2003; 97:563-567
14. Han Z, Xu J, and Zhong NS. TNF, Con A and mechanical Injury stimulate matrix metalloproteinase-
9 expression in human bronchial endothelial cell. Chinese Journal of Pathophysiology. 2002;
18(7):741-744 (in Chinese)
15. Han, Z, Xu J, and Zhong NS. The expression of matrix metalloproteinase- 9 and the effect of
interleukin-10 gene transfer in Balb/c mice infected by respiratory syncytial virus. Chinese Journal of
Pathophysiology. (accepted for publication), 2002 (in Chinese)
16. Han Z, Xu J, and Zhong NS. Clinical study of Matrix Metallopreoteinase-9 by airway biopsy from
asthmatic subjects. Chinese Journal of Practical Internal Medicine 2002;22 (6): 331-3 (in Chinese)
17. Han Z, Xu J., and Zhong NS. The Matrix Metalloproteinases-9 expression from lung tissue in OVA
sensitized guinea pigs and the effect of antisense endothelin converting enzyme gene transfer. Chinese
Journal of Tuberculosis and Respiratory Medicine 2001; 45(11):702-703 (in Chinese)
18. Han Z, He Q. Quantitative analysis for emphysemous area using High resolution CT and its
relationship to interlukin-8 plasma in subjects with emphysema. Chinese Journal of Practical Internal
Medicine 2001; 47 (9): 546-547. (in Chinese)
19. Han Z, He Q. The increased expression of matrix metalloproteinase in BALF of emphysema.
Foreign Medicine Science-Branch of Internal Medicine 1999;17(5):122- 123 (in Chinese)
20. Han Z, Xu J., and Zhong NS. The expression of Matrix Metalloproteinases-9 in human airway
epithelial cell. Chinese Journal of Tuberculosis and Respiratory Medicine 2000;23(12):747-49
21. Han Z, Xu J, Zhong NS. Matrix Metalloproteases and respiratory diseases. Foreign Medicine Science
–Branch of Internal Medicine. 2000; 20(5):192-196 (in Chinese)
22. Han Z, He Q. The advancement of Chronic Obstructive Pulmonary Disease (COPD) pathogenesis.
Foreign Medicine Science -Branch of Respiratory Medicine supplement. 1998; 17(2)533-35 (in
Chinese)
学术兼职
广州呼吸病研究所所长，
呼吸疾病国家重点实验室主任，
中华医学会前会长，
世界卫生组织医学顾问
京公网安备 11010802027423号