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个人简介

2003--2007湖北大学 生物科学 学士 2007--2012中国科学院广州生物医药与健康研究院 生化与分子生物学 博士 2012--2013中国科学院广州生物医药与健康研究院 助理研究员 2013--2017中国科学院广州生物医药与健康研究院 副研究员 2018至今 中国科学院广州生物医药与健康研究院 研究员 获奖及荣誉 国家自然科学基金优秀青年(2020年) 中国科学院杰出科技成就奖(2017年,主要完成者) 广东省科学技术一等奖(2015年) 广州市科学技术一等奖(2015年) 广东省特支计划科技创新青年拔尖人才(2016年) 广州市珠江科技新星(2014年)

研究领域

多能干细胞与细胞命运调控 主要研究方向 1)基于iPSC和PNT体系的细胞命运调控机制研究 2)多物种多能干细胞建系及疾病动物模型建立 3)细胞命运转变过程的多维数据分析与数学建模

近期论文

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Yu, S., C. Zhou, S. Cao, J. He, B. Cai, K. Wu, Y. Qin, X. Huang, L. Xiao, J. Ye, S. Xu, W. Xie, J. Kuang, S. Chu, J. Guo, H. Liu, W. Pang, L. Guo, M. Zeng, X. Wang, R. Luo, C. Li, G. Zhao, B. Wang, L. Wu, J. Chen, J. Liu and D. Pei (2020). "BMP4 resets mouse epiblast stem cells to naive pluripotency through ZBTB7A/B-mediated chromatin remodelling." Nat Cell Biol 22(6): 651-662. Wang, B., L. Wu, D. Li, Y. Liu, J. Guo, C. Li, Y. Yao, Y. Wang, G. Zhao, X. Wang, M. Fu, H. Liu, S. Cao, C. Wu, S. Yu, C. Zhou, Y. Qin, J. Kuang, J. Ming, S. Chu, X. Yang, P. Zhu, G. Pan, J. Chen, J. Liu and D. Pei (2019). "Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Essrb-Sall4." Cell Rep 27(12): 3473-3485 e3475. Cao, S., S. Yu, D. Li, J. Ye, X. Yang, C. Li, X. Wang, Y. Mai, Y. Qin, J. Wu, J. He, C. Zhou, H. Liu, B. Zhao, X. Shu, C. Wu, R. Chen, W. Chan, G. Pan, J. Chen, J. Liu and D. Pei (2018). "Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency." Cell Stem Cell 22(4): 529-542 e525. Wang, B., D. Li, J. Chen, J. Liu and D. Pei (2018). "Mouse embryonic stem cells resist c-Jun induced differentiation when in suspension." Cell Regen 7(1): 16-21. Li, D., J. Liu, X. Yang, C. Zhou, J. Guo, C. Wu, Y. Qin, L. Guo, J. He, S. Yu, H. Liu, X. Wang, F. Wu, J. Kuang, A. P. Hutchins, J. Chen and D. Pei (2017). "Chromatin Accessibility Dynamics during iPSC Reprogramming." Cell Stem Cell 21(6): 819-833 e816. Cao, S., S. Yu, Y. Chen, X. Wang, C. Zhou, Y. Liu, J. Kuang, H. Liu, D. Li, J. Ye, Y. Qin, S. Chu, L. Wu, L. Guo, Y. Li, X. Shu, J. Chen, J. Liu and D. Pei (2017). "Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage." J Biol Chem 292(46): 19122-19132. Liu, J., Q. Han, T. Peng, M. Peng, B. Wei, D. Li, X. Wang, S. Yu, J. Yang, S. Cao, K. Huang, A. P. Hutchins, H. Liu, J. Kuang, Z. Zhou, J. Chen, H. Wu, L. Guo, Y. Chen, Y. Chen, X. Li, H. Wu, B. Liao, W. He, H. Song, H. Yao, G. Pan, J. Chen and D. Pei (2015). "The oncogene c-Jun impedes somatic cell reprogramming." Nat Cell Biol 17(7): 856-867. Ouyang, J., W. Yu, J. Liu, N. Zhang, L. Florens, J. Chen, H. Liu, M. Washburn, D. Pei and T. Xie (2015). "Cyclin-dependent kinase-mediated Sox2 phosphorylation enhances the ability of Sox2 to establish the pluripotent state." J Biol Chem 290(37): 22782-22794. Chen, J., J. Liu, J. Yang, Y. Chen, J. Chen, S. Ni, H. Song, L. Zeng, K. Ding and D. Pei (2011). "BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone." Cell Res 21(1): 205-212. Chen, J., J. Liu, Y. Chen, J. Yang, J. Chen, H. Liu, X. Zhao, K. Mo, H. Song, L. Guo, S. Chu, D. Wang, K. Ding and D. Pei (2011). "Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics." Cell Res 21(6): 884-894. Chen, J., J. Liu, Q. Han, D. Qin, J. Xu, Y. Chen, J. Yang, H. Song, D. Yang, M. Peng, W. He, R. Li, H. Wang, Y. Gan, K. Ding, L. Zeng, L. Lai, M. A. Esteban and D. Pei (2010). "Towards an optimized culture medium for the generation of mouse induced pluripotent stem cells." J Biol Chem 285(40): 31066-31072.

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