何俊 - 中国科学院广州生物医药与健康研究院 -

个人简介

2018 中科院广州生物医药与健康研究院研究员 2016-2018 Senior Scientist, UCB Pharma 2013-2016 Post-doctoral Research Fellow, the Francis Crick Institute. Supervisor: Dr. John Diffley, FRS 2012-2013 Post-doctoral Scientist, The Institute of Cancer Research, London. Supervisor: Dr David Barford, FRS 2008-2012 PhD at The Institute of Cancer Research, London. Supervisors: Dr David Barford FRS and Dr Ed Morris 2002-2006 理学学士清华大学生物科学获奖及荣誉： 2013 Chairman’s Prize for Best PhD, the Institute of Cancer Research 2012 Chinese Government Award for outstanding students abroad

研究领域

综合低温冷冻电镜技术和X射线晶体学技术等多种结构生物学研究手段，在多尺度上来研究生物系统的高分辨率构造。主要研究方向为调控细胞命运调控因子的结构与功能的关系，以及细胞命运转变分子机制的探索。

近期论文

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Frigola, J.*, He, J.*, Kinkeilin, K., Pye, V., Renault, L., Douglas, M., Remus, D., Cherepanov, P., Costa, A., Diffley, J.F.X. (2017). Cdt1 stabilises an open MCM ring for helicase loading. Nat. Commun, 8, 15720. He, J.*, Chao, W.C.*, Zhang, Z., Yang, J., Cronin, N., & Barford, D. (2013). Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex. Molecular cell, 50(5):649-60. da Fonseca, P. C., He, J., & Morris, E. P. (2012). Molecular model of the human 26S proteasome. Molecular cell, 46(1), 54-66. He, J.*, Kulkarni, K.*, da Fonseca, P. C., Krutauz, D., Glickman, M. H., Barford, D., & Morris, E. P. (2012). The Structure of the 26S Proteasome Subunit Rpn2 Reveals Its PC Repeat Domain as a Closed Toroid of Two Concentric α-Helical Rings. Structure, 20(3), 513-521.