个人简介

Born in Rome (Italy) on 1 May 1963, Dario Neri studied Chemistry at the Scuola Normale Superiore of Pisa, graduating with a thesis on the synthesis and characterization of complex polyunsaturated secondary metabolites, isolated from higher plants. He earned his doctorate in Chemistry under the supervision of Prof. Dr. Kurt Wüthrich at the Institute of Molecular Biology and Biophysics of the ETH Zürich in 1992, receiving the Silver Medal of ETH Zürich for his dissertation. With an EU Bridge Bursary, Dario Neri worked from 1992 until 1996 at the Cambridge Centre for Protein Engineering, Medical Research Council Centre, under the supervision of Sir Gregory Winter. He has now been a Professor at the ETH Zurich since 1996. Dario Neri has published over 300 articles in peer-reviewed scientific journals. He is the recipient of the ISOBM Abbott Prize 2000, of the Amgen-Dompe’ Biotec Award 2000, of the Mangia d’Oro 2001, of the Prous Award 2006 of the European Federation of Medicinal Chemistry, of the Robert-Wenner-Prize 2007 of the Swiss Cancer League, of the SWISS BRIDGE Award 2008, of the 2011 Prix Mentzer of the French Society for Medicinal Chemistry (RICT) and of the Phoenix Award 2014 for Pharmacology and Clinical Pharmacy.

研究领域

Biomacromolecules

The research of the group Neri focuses on the engineering of therapeutic antibodies for the treatment of cancer and of chronic inflammatory conditions. Other research activities include the development of DNA-encoded chemical libraries and of small molecule-drug conjugates. Furthermore, the group uses mass spectrometry methodologies for the discovery of vascular markers of disease and for HLA peptidome analysis.

近期论文

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Wichert, Moreno and Krall, Nikolaus and Decurtins, Willy and Franzini, Raphael M. and Pretto, Francesca and Schneider, Petra and Neri, Dario and Scheuermann, Jörg. "Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation", 2015, Nature Chemistry Hemmerle, Teresa and Zgraggen, Silvana and Matasci, Mattia and Halin, Cornelia and Detmar, Michael and Neri, Dario. "Antibody-mediated delivery of interleukin 4 to the neo-vasculature reduces chronic skin inflammation", 2014, Journal of Dermatological Science Putelli, Alessia and Kiefer, Jonathan D. and Zadory, Matthias and Matasci, Mattia and Neri, Dario. "A Fibrin-Specific Monoclonal Antibody from a Designed Phage Display Library Inhibits Clot Formation and Localizes to Tumors In Vivo", 2014, Journal of molecular biology Krall, N. and Pretto, F. and Neri, D. "A bivalent small molecule-drug conjugate directed against carbonic anhydrase IX can elicit complete tumour regression in mice", 2014, Chemical science Pretto, Francesca and Elia, Giuliano and Castioni, Nadia and Neri, Dario. "Preclinical evaluation of IL2-based immunocytokines supports their use in combination with dacarbazine, paclitaxel and TNF-based immunotherapy", 2014, Cancer immunology and immunotherapy Franzini, Raphael M. and Samain, Florent and Abd Elrahman, Maaly and Mikutis, Gediminas and Nauer, Angela and Zimmermann, Mauro and Scheuermann, Jörg and Hall, Jonathan and Neri, Dario. "Systematic evaluation and optimization of modification reactions of oligonucleotides with amines and carboxylic acids for the synthesis of dna-encoded chemical libraries", 2014, Bioconjugate chemistry Hemmerle, T. and Doll, F. and Neri, D. "Antibody-based delivery of IL4 to the neovasculature cures mice with arthritis", 2014, Proceedings of the National Academy of Sciences of the United States of America Elia, Giuliano and Fugmann, Tim and Neri, Dario. "From target discovery to clinical trials with armed antibody products", 2014, Journal of proteomics Gutbrodt, Katrin L. and Casi, Giulio and Neri, Dario. "Antibody-based delivery of interleukin-2 and cytotoxics eradicates tumors in immunocompetent mice", 2014, Molecular cancer therapeutics Hess, Christian and Neri, Dario. "Evaluation of antibody-chemokine fusion proteins for tumor-targeting applications", 2014, Experimental biology and medicine Bujak, E. and Pretto, F. and Ritz, D. and Gualandi, L. and Wulhfard, S. and Neri, D. "Monoclonal antibodies to murine thrombospondin-1 and thrombospondin-2 reveal differential expression patterns in cancer and low antigen expression in normal tissues", 2014, Experimental cell research Weber, Marcel and Bujak, Emil and Putelli, Alessia and Villa, Alessandra and Matasci, Mattia and Gualandi, Laura and Hemmerle, Teresa and Wulhfard, Sarah and Neri, Dario. "A Highly Functional Synthetic Phage Display Library Containing over 40 Billion Human Antibody Clones", 2014, PLoS ONE Botter, Sander M. and Neri, Dario and Fuchs, Bruno. "Recent advances in osteosarcoma", 2014, Current opinion in pharmacology Hemmerle, Teresa and Neri, Dario. "The Dose-Dependent Tumor Targeting of Antibody-IFN gamma Fusion Proteins Reveals an Unexpected Receptor-Trapping Mechanism In Vivo", 2014, Cancer immunology research Aloj, Luigi and D’Ambrosio, Laura and Aurilio, Michela and Morisco, Anna and Frigeri, Ferdinando and Caraco, Corradina and Di Gennaro, Francesca and Capobianco, Gaetana and Giovannoni, Leonardo and Menssen, Hans D. and Neri, Dario and Pinto, Antonio and Lastoria, Secondo. "Radioimmunotherapy with Tenarad, a 131I-labelled antibody fragment targeting the extra-domain A1 of tenascin-C, in patients with refractory Hodgkin's lymphoma", 2014, European Journal of Nuclear Medicine and Molecular Imaging Perrino, Elena and Steiner, Martina and Krall, Nikolaus and Bernardes, Gonçalo J.L. and Pretto, Francesca and Casi, Giulio and Neri, Dario. "Curative Properties of Noninternalizing Antibody–Drug Conjugates Based on Maytansinoids", 2014, Cancer research Franzini, Raphael M. and Neri, Dario and Scheuermann, Jörg. "DNA-encoded chemical libraries", 2014, Accounts of chemical research Hess, Christian and Venetz, Dario and Neri, Dario. "Emerging classes of armed antibody therapeutics against cancer", 2014, MedChemComm Krall, Nikolaus and Pretto, Francesca and Decurtins, Willy and Bernardes, Gonçalo J. L. and Supuran, Claudiu T. and Neri, Dario. "A small-molecule drug conjugate for the treatment of carbonic anhydrase IX expressing tumors", 2014, Angewandte Chemie - International Edition Strassberger, Verena and Gutbrodt, Katrin L. and Krall, Nikolaus and Roesli, Christoph and Takizawa, Hitoshi and Manz, Markus G. and Fugmann, Tim and Neri, Dario. "A comprehensive surface proteome analysis of myeloid leukemia cell lines for therapeutic antibody development", 2014, Journal of Proteomics