个人简介

W. H. Koppenol was born in the Netherlands in 1949. He studied chemistry at the University of Utrecht, obtained a master's degree in inorganic chemistry and geochemistry in 1974 and finished his studies with a doctoral degree in radiation chemistry in 1978. He then joined the group of Professor E. Margoliash at the Department of Biochemistry and Molecular Biology at Northwestern University in Evanston, Illinois, where he studied electrostatic properties of proteins, in particular cytochrome c and superoxide dismutase. From the end of 1981 until the summer of 1987 he worked as assistant professor at the Department of Chemistry of the University of Maryland, Baltimore County. There he continued his research on electrostatic properties of proteins and started to investigate the kinetic and thermodynamic properties of inorganic radicals. In 1983 he received the Iron Bolt Award for his research on the thermodynamic feasibility of radical reactions. In 1987 he was appointed associate professor at the Department of Chemistry of Louisiana State University in Baton Rouge, where he continued his investigations of reactions that involve radicals. From 1990 until the end of 1997, Prof. Koppenol was a member of the IVPAC Commission on the Nomenclature of Inorganic Chemistry; the last four years he served as Secretary. Currently, he is a member of the editorial boards of Redox Reports Archives of Biochemistry and Biophysics, Chemical Research in Toxicology and Helvetica Chimica Acta.

研究领域

Bioinorganic Chemistry

Willem H. Koppenol joined the ETH Zurich in 1994 as full Professor; presently his research interests are: Kinetics and thermodynamics of radical reactions that are of biological interest, reactivity of nitrogen oxides, peroxynitrite and peroxides in general, metal binding properties of superoxide dismutase.

近期论文

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K. Junker, G. Zandomeneghi, L. D. Schuler, R. Kissner, P. Walde, Enzymatic polymerization of pyrrole with Trametes versicolor laccase and dioxygen in the presence of vesicles formed from AOT (sodium bis-(2-ethylhexyl) sulfosuccinate) as templates, Synthetic Met., 2015, 200, 123-134. T. Nauser, W. H. Koppenol, C. Schöneich, Protein thiyl radical reactions and product formation: a kinetic simulation, Free Radical Biol.Med., 2015, 80, 158-163. C. S. Müller, T. Knehans, D. R. Davydov, P. L. Bounds, U. von Mandach, J. R. Halpert, A. Caflisch, W. H. Koppenol, Concurrent cooperativity and substrate inhibition in the epoxidation of carbamazepine by cytochrome P450 3A4 active site mutants inspired by molecular dynamics simulations, Biochemistry, 2015, 54, 711-721. A. M. Faure, W. H. Koppenol, L. Nyström, Iron(II) binding by cereal beta-glucan, Carbohydr. Polym., 2015, 115, 739-743. Peer reviewed contributions 2014 T. Nauser, A. Carreras, Carbon-centered scavenger radicals add reversibly to histidine – implications, Chem. Comm., 2014, 50, 14349-14351. K. Junker, S. Luginbühl, M. Schüttel, L. Bertschi, R. Kissner, L. D. Schuler, B. Rakvin, P. Walde, Efficient polymerization of the aniline dimer p-Aminodiphenylamine (PADPA) with Trametes versicolor laccase/O2 as catalyst and oxidant and AOT vesicles as templates, ACS Catalysis, 2014, 4, 3421-3434. L. Mahmoudi, R. Kissner, Electrode reactions of iron oxide-hydroxide colloids, Dalton Trans., 2014, 43, 15407-15413. J. Penders, R. Kissner, W. H. Koppenol, ONOOH does not react with H2: potential beneficial effects of H2 as an antioxidant by selective reaction with hydroxyl radicals and peroxynitrite, Free Radical Biol. Med., 2014, 75, 191-194. T. Nauser, D. Steinmann, G. Grassi, W. H. Koppenol, Why selenocysteine replaces cysteine in thioredoxin reductase: a radical hypothesis, Biochemistry, 2014, 53, 5017-5022. Y. Lee, R. Kissner, U. von Gunten, Reaction of ferrate(VI) with ABTS and self-decay of ferrate(VI): kinetics and mechanisms, Environ. Sci. & Technol., 2014, 48, 5154–5162. A. S. Domazou, L. Gebicka, J. Didik, J. L. Gebicki, B. van der Meijden, W. H. Koppenol, The kinetics of the reaction of nitrogen dioxide with iron(II)- and iron(III)cytochrome c, Free Radical Biol. Med., 2014, 69, 172-180. C. Schöneich, O. Mozziconacci, W. H. Koppenol, T. Nauser, Intramolecular 1,2- and 1,3-hydrogen transfer reactions of thiyl radicals, Isr. J. Chem., 2014, 54, 265-271. A. S. Domazou, J. M. Gebicki, T. Nauser, W. H. Koppenol, Repair of protein radicals by antioxidants, Isr. J. Chem., 2014, 54, 254-264. A. B. Das, T. Nauser, W. H. Koppenol, A. J. Kettle, C. C. Winterbourn, P. Nagy, Rapid reaction of superoxide with insulin-tyrosyl radicals to generate a hydroperoxide with subsequent glutathione addition, Free Radical Biol. Med., 2014, 70, 86-95. N. Santschi, R. C. Sarott, E. Otth, R. Kissner, A. Togni, Synthesis, characterization and initial evaluation of 5-nitro-1-(trifluoromethyl)-3H-1λ3,2-benziodaoxol-3-one, Beilstein J. Org. Chem., 2014, 10, 1-6. K. Junker, R. Kissner, B. Rakvin, Z. Guo, M. Willeke, S. Busato, T. Weber, P. Walde, The use of Trametes versicolor laccase for the polymerization of aniline in the presence of vesicles as templates, Enzyme Microb. Technol., 2014, 55, 72-84. K. Eyer, F. Paech, F. Schuler. P. Kuhn, R. Kissner, S. Belli, P. S. Dittrich, S. D. Krämer, A liposomal fluorescence assay to study permeation kinetics of drug-like weak bases across the lipid bilayer, J. Controlled Release, 2014, 173, 102-109. Peer reviewed contributions 2013 T. S. Koskenkorva-Frank, G. Weiss, W. H. Koppenol, S. Burckhardt, The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: Insights into the potential of various iron therapies to induce oxidative and nitrosative stress, Free Radical Biol. Med., 2013, 65, 1174-1194. D. A. Armstrong, R. E. Huie, S. Lymar, W. H. Koppenol, G. Merényi, P. Neta, D. M. Stanbury, S. Steenken, P. Wardman, Standard electrode potentials involving radicals in aqueous solution: inorganic radicals, BioInorganic Reaction Mechanisms, 2013, 9, 59-61. A. Grotzky, E. Altamura, J. Adamcik, P. Carrara, P. Stano, F. Mavelli, T. Nauser, R. Mezzenga, A. D. Schlüter, P. Walde, Structure and enzymatic properties of molecular dendronized polymer-enzyme conjugates and their entrapment inside giant vesicles, Langmuir, 2013, 29, 10831-10840.