个人简介

Professor Hilvert was born in 1956 in Cincinnati, Ohio, USA, and obtained his B.A. from Brown University, Rhode Island, in 1978. He earned his Ph.D. from Columbia University, New York, in 1983, with a dissertation under the supervision of Prof. R. Breslow. Following a postdoctoral work with Prof. E.T. Kaiser at Rockefeller University, New York, he joined the Scripps Research Institute as an assistant professor in 1986, where he was named associate professor in 1989 and full professor in 1993. He came to ETH Zurich as full Professor of Organic Chemistry in 1997. Donald Hilvert was awarded the Alfred P. Sloan Research Fellowship in 1991-93, the Arthur C. Cope Scholar Award of the ACS in 1992, and the Pfitzer Award in Enzyme Chemistry in 1994.

研究领域

Biological Chemistry /Chemical Biology

Donald Hilvert has been full Professor at the Organic Chemistry Laboratory of ETH Zurich since October 1, 1997. His group is developing general strategies for the design of proteins with customized catalytic properties. The aim is to gain a better understanding of the molecular origins of the catalytic powers of natural enzymes and their selectivity. Beyond that artificial biocatalysts may be useful in research, medicine and industry.

近期论文

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Construction of Matryoshka-Type Structures from Supercharged Protein Nanocages Beck, T., Tetter, S., Künzle, M., Hilvert, D., Angew. Chem. 2014, DOI: 10.1002/ange.201408677 Reprogramming Nonribosomal Peptide Synthetases for "Clickable" Amino Acids Kries, H., Wachtel, R., Pabst, A., Wanner, B., Niquille, D., Hilvert, D., Angew. Chem. VIP 2014, 53, 1 – 5 Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase Preiswerk, N., Beck, T., Schulz, J.D., Milovnik, P., Mayer, C., Siegel, J. B., Baker, D. and Hilvert, D., PNAS 2014, doi: 10.1073/pnas.1401073111 Building Proficient Enzymes with Foldamer Prostheses Mayer, C., Müller, M. M., Gellman, S. H., Hilvert, D., Angew. Chem. 2014, 126, 1 – 5 Both the cis-trans equilibrium and isomerization dynamics of a single proline amide modulate ß2-microglobulin amyloid assembly Torbeev, V. Y., Hilvert, D., Proc. Natl. Acad. Sci. 2013 Precision is essential for efficient catalysis in an evolved Kemp eliminase Blomberg, R., Kries, H., Pinkas, D.M., Mittl, P.R., Grütter, M.G., Privett, H.K., Mayo, S.L., Hilvert, D., Nature 2013 Design of Protein Catalysts Hilvert, D., Annual Reviews of Biochemistry 2013, 82 (1), 447-470 Evolution of a designed retro-aldolase leads to complete active site remodeling Giger, L., Caner, S., Obexer, R., Kast, P., Baker, D., Ban, N., and Hilvert, D., Nature Chemical Biology 2013, 494-498 A Genetically Encodable Ligand for Transfer Hydrogenation Mayer, C., Hilvert, D., European Journal of Organic Chemistry 2013, 16, 3427-3431 Affinity maturation of a computationally designed binding protein affords a functional but disordered polypeptide Butz, M., Kast, P., Hilvert, D., Journal of Structural Biology 2013, in press Protein Conformational Disorder and Enzyme Catalysis Schulenburg, C., Hilvert, D., Topics in Current Chemistry 2013 De novo enzymes by computational design Kries, H., Blomberg, R., Hilvert, D., Curr. Op. Chem. Biol., 2013, 17, 221-228 Directed Evolution of a Primordial Enzyme Provides Insights into the Development of the Genetic Code Müller, M. M., Allison, J. R., Hongdilokkul, N., Gaillon, L., Kast, P., van Gunsteren, W. F., Marliere, P., Hilvert, D., PLOS Genetics 2013, 9, e1003187 De novo Chemoenzymatic Synthesis of Sialic Acid Stallforth, P., Matthies, S., Adibekian, A., Gillingham, D. G., Hilvert, D., Seeberger, P. H., Chem. Comm. 2012, 48, 11987-11989 cis-trans Peptide-Bond Isomerization in alpha-Methylproline Derivatives Torbeev, V.Y., Fumi E., Ebert, M.O., Schweizer, W. B., Hilvert, D., Helvetica Chimica Acta 2012, 95, 2411-2420 Computational Design of Catalytic Dyads and Oxyanion Holes for Ester Hydrolysis Richter, F., Blomberg, R., Khare, S. D., Kiss, G., Kuzin, A. P., Smith, A. J. T., Gallaher, J., Pianowski, Z., Helgeson, R. C., Grjasnow, A., Xiao, R., Seetharaman, J., Su, M., Vorobiev, S., Lew, S., Forouhar, F., Kornhaber, G. J., Hunt, J. F., Montelione, G. T., Tong, L., Houk, K. N., Hilvert, D., Baker, D., JACS, 2012, 39, 16197-16206 A novel genetic selection system for PLP-dependent threonine aldolases Giger, L., Toscano, M. D., Bouzon, M., Marliere, P., Hilvert, D., Tetrahedron, 2012, 68, 7549-7557 Strategic Use of Non-native Diselenide Bridges to Steer Oxidative Protein Folding Metanis, N., Hilvert, D., Angew. Chem., Int. Ed. Engl., 2012 Harnessing Protein Symmetry for Enzyme Design Wörsdörfer, B., Henning, L. M., Obexer, R., Hilvert, D., ACS Catalysis, 2012 Iterative approach to computational enzyme design Privett, H. K., Kiss, G., Lee, T. M., Blomberg, R., Chica, R. A., Thomas, M. L., Hilvert, D., Houk, K. N., Mayo, S. L., PNAS, 2012