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Construction of Matryoshka-Type Structures from Supercharged Protein Nanocages
Beck, T., Tetter, S., Künzle, M., Hilvert, D., Angew. Chem. 2014, DOI: 10.1002/ange.201408677
Reprogramming Nonribosomal Peptide Synthetases for "Clickable" Amino Acids
Kries, H., Wachtel, R., Pabst, A., Wanner, B., Niquille, D., Hilvert, D., Angew. Chem. VIP 2014, 53, 1 – 5
Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase
Preiswerk, N., Beck, T., Schulz, J.D., Milovnik, P., Mayer, C., Siegel, J. B., Baker, D. and Hilvert, D., PNAS 2014, doi: 10.1073/pnas.1401073111
Building Proficient Enzymes with Foldamer Prostheses
Mayer, C., Müller, M. M., Gellman, S. H., Hilvert, D., Angew. Chem. 2014, 126, 1 – 5
Both the cis-trans equilibrium and isomerization dynamics of a single proline amide modulate ß2-microglobulin amyloid assembly
Torbeev, V. Y., Hilvert, D., Proc. Natl. Acad. Sci. 2013
Precision is essential for efficient catalysis in an evolved Kemp eliminase
Blomberg, R., Kries, H., Pinkas, D.M., Mittl, P.R., Grütter, M.G., Privett, H.K., Mayo, S.L., Hilvert, D., Nature 2013
Design of Protein Catalysts
Hilvert, D., Annual Reviews of Biochemistry 2013, 82 (1), 447-470
Evolution of a designed retro-aldolase leads to complete active site remodeling
Giger, L., Caner, S., Obexer, R., Kast, P., Baker, D., Ban, N., and Hilvert, D., Nature Chemical Biology 2013, 494-498
A Genetically Encodable Ligand for Transfer Hydrogenation
Mayer, C., Hilvert, D., European Journal of Organic Chemistry 2013, 16, 3427-3431
Affinity maturation of a computationally designed binding protein affords a functional but disordered polypeptide
Butz, M., Kast, P., Hilvert, D., Journal of Structural Biology 2013, in press
Protein Conformational Disorder and Enzyme Catalysis
Schulenburg, C., Hilvert, D., Topics in Current Chemistry 2013
De novo enzymes by computational design
Kries, H., Blomberg, R., Hilvert, D., Curr. Op. Chem. Biol., 2013, 17, 221-228
Directed Evolution of a Primordial Enzyme Provides Insights into the Development of the Genetic Code
Müller, M. M., Allison, J. R., Hongdilokkul, N., Gaillon, L., Kast, P., van Gunsteren, W. F., Marliere, P., Hilvert, D., PLOS Genetics 2013, 9, e1003187
De novo Chemoenzymatic Synthesis of Sialic Acid
Stallforth, P., Matthies, S., Adibekian, A., Gillingham, D. G., Hilvert, D., Seeberger, P. H., Chem. Comm. 2012, 48, 11987-11989
cis-trans Peptide-Bond Isomerization in alpha-Methylproline Derivatives
Torbeev, V.Y., Fumi E., Ebert, M.O., Schweizer, W. B., Hilvert, D., Helvetica Chimica Acta 2012, 95, 2411-2420
Computational Design of Catalytic Dyads and Oxyanion Holes for Ester Hydrolysis
Richter, F., Blomberg, R., Khare, S. D., Kiss, G., Kuzin, A. P., Smith, A. J. T., Gallaher, J., Pianowski, Z., Helgeson, R. C., Grjasnow, A., Xiao, R., Seetharaman, J., Su, M., Vorobiev, S., Lew, S., Forouhar, F., Kornhaber, G. J., Hunt, J. F., Montelione, G. T., Tong, L., Houk, K. N., Hilvert, D., Baker, D., JACS, 2012, 39, 16197-16206
A novel genetic selection system for PLP-dependent threonine aldolases
Giger, L., Toscano, M. D., Bouzon, M., Marliere, P., Hilvert, D., Tetrahedron, 2012, 68, 7549-7557
Strategic Use of Non-native Diselenide Bridges to Steer Oxidative Protein Folding
Metanis, N., Hilvert, D., Angew. Chem., Int. Ed. Engl., 2012
Harnessing Protein Symmetry for Enzyme Design
Wörsdörfer, B., Henning, L. M., Obexer, R., Hilvert, D., ACS Catalysis, 2012
Iterative approach to computational enzyme design
Privett, H. K., Kiss, G., Lee, T. M., Blomberg, R., Chica, R. A., Thomas, M. L., Hilvert, D., Houk, K. N., Mayo, S. L., PNAS, 2012