个人简介

Rudiyanto Gunawan has been an Assistant Professor of Chemical and Biological Systems Engineering in the Department of Chemistry and Applied Biosciences since 2011. He was born in Jakarta, Indonesia, in 1976. He obtained a BSc in chemical engineering and mathematics from the University of Wisconsin-Madison in 1998 and an MSc from the University of Illinois Urbana-Champaign in 2000. In 2003 Rudiyanto Gunawan completed a PhD in chemical engineering at the University of Illinois Urbana-Champaign. Honours Year Distinction 2008 Best Theory/Methodology Paper 2005-2008 from the Journal of Process Control 2006 Best Paper Award from the Journal "Computers and Chemical Engineering"

研究领域

Chemical & Biological Systems Engineering

Rudiyanto Gunawan’s research lies at the interface between biology and systems engineering. His aim is to create enabling systems theories and methods for generating insights, understanding and knowledge for chemical, biological and medical applications. To this end, the group is interested in the development of algorithms and computational tools to build models of biological and chemical systems from data and analyze their systems properties, such as robustness and fragility. There are three specific areas the group is involved in: (1) the development of model-building and identification methodologies, including model identifiability analysis and parameter estimation, (2) the development of systems analyses, in particular sensitivity analyses, to understand system dynamics and (3) the modeling and analysis of mitochondria physiology, specifically in cell death and cellular ageing.

近期论文

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Tam, Z., Gruber, J., Halliwell, B. and Gunawan R. Context-Dependent Role of Mitochondrial Fusion-Fission in Clonal Expansion of mtDNA Mutations. PLoS Computational Biology. accepted. Liu, Y., and Gunawan, R. Parameter estimation of dynamic biological network models using integrated fluxes. BMC Systems Biology 8, 127 (2014). abstract Ud-Dean, SMM., and Gunawan, R. Ensemble Inference and Inferability of Gene Regulatory Networks. PLoS ONE, 9(8), e103812 (2014). abstract Siegenthaler, C., and Gunawan, R. Assessment of Network Inference Methods: How to Cope with an Underdetermined Problem. PLoS ONE, 9(3), e90481 (2014). abstract Perumal, T. M., and Gunawan, R. pathPSA: a dynamical pathway-based parametric sensitivity analysis. Ind. Eng. Chem. Res., (2014) abstract Tam, Z., Gruber, J., Ng, L.F., Halliwell, B. and Gunawan R. Effects of Lithium on Age-related Decline in Mitochondrial Turnover and Function in Caenorhabditis elegans. J Gerontol A, (2014) abstract Tam, Z., Gruber, J., Halliwell, B. and Gunawan R. Mathematical Modeling of the Role of Mitochondrial Fusion and Fission in Mitochondrial DNA Maintenance. PLoS One, 8, e76230 (2013). abstract Perumal, T. M., Krishna, S. M., Tallam, S. S. & Gunawan, R. Reduction of Kinetic Models using Dynamic Sensitivities. Computers & Chemical Engineering, 56, 37-45 (2013) abstract Poovathingal, S. K., Gruber, J., Lakshmanan, LN., Halliwell, B. & Gunawan, R. Is mitochondrial DNA turnover slower than commonly assumed? Biogerontology 13, 557-564 (2012). abstract Jia, G., Stephanopoulos, G., Gunawan, R. Incremental parameter estimation of kinetic metabolic network models. BMC Systems Biology 6, 142 (2012). abstract Lakshmanan, LN., Gruber, J., Halliwell, B. & Gunawan, R. Role of direct repeat and stem-loop motifs in mtDNA deletions: cause or coincidence? PLoS One 7, e35271 (2012). abstract Jia, G., Stephanopoulos, G. & Gunawan, R. Ensemble Kinetic Modeling of Metabolic Networks from Dynamic Metabolic Profiles. Metabolites 2, 891–912 (2012). abstract Toldy, A. I., Badruddoza, A. Z. M., Lu, Z., Hatton, T. A., Gunawan, R., Rajagopalan, R. and Khan, S. A. Spherical Crystallization of Glycine from Monodisperse Microfluidic Emulsions. Crystal Growth & Design 12, 3977–3982 (2012). abstract Poovathingal, S. K., Gruber, J., Ng, L. F., Halliwell, B. & Gunawan, R. Maximizing signal-to-noise ratio in the random mutation capture assay. Nucleic Acids Research 40, e35 (2012). abstract G. Jia and R. Gunawan Construction of Kinetic Model Library of Metabolic Networks, In Proc. of the 8th IFAC International Symposium on Advanced Control of Chemical Process, pp. 952-957, 2012. abstract Jia, G., Stephanopoulos, G. N. & Gunawan, R. Parameter estimation of kinetic models from metabolic profiles : two-phase dynamic decoupling method. Bioinformatics 27, 1964–1970 (2011). abstract Perumal, T. M. & Gunawan, R. Understanding dynamics using sensitivity analysis: caveat and solution. BMC Systems Biology 5, 41 (2011). abstract T.M. Perumal and R. Gunawan. Impulse parametric sensitivity analysis. In Proc. of the 18th IFAC World Congress, pp. 9896-9890, 2011. abstract G. Jia and R. Gunawan, Construction of Kinetic Model Library of Metabolic Networks from Dynamic Profiles, In the 8th International Workshop on Computational Systems Biology, TICSP series #57, 2011. abstract Z. Y. Tam and R. Gunawan, On the Roles of Mitochondrial Fusion-Fission in Mitochondrial Genome Integrity, In Proc of the 8th International Workshop on Computational System Biology, TICSP series #57, 2011. abstract