个人简介

Gerd Folkers has been Full Professor of Pharmaceutical Chemistry at the ETH Zurich since April 1st, 1991. On 1 October 2004 he has taken the chair of Collegium Helveticum, the interdisciplinary institution, which - starting in autumn - will be run jointly by the University of Zurich and the ETH Zurich. He was born on the March 25, 1953 in Andernach/Rhein in Germany. He studied pharmacy at the University of Bonn. Under H.J. Roth he earned his Ph.D in Bonn on structure activity relationships of desapurines. In 1983 he transferred together with his mentor to the University of Tübingen, where he completed habilitation in 1989 in pharmaceutical chemistry. During a stay in Bern, Switzerland, he studied new research methods in computer aided molecular design. He expanded his knowledge during other stays abroad, especially with T. Blundell at the Birkbeck College in London and E. Meyer at Texas A&M University.

研究领域

Pharmaceutical Chemistry

The focus of his research work is the molecular interaction between drugs and its binding sites in vivo. He is particularly interested in the strong integration of computer aided modeling and relevant biochemical/biophysical experiments. Besides the research on molecular mechanism of ""conventional"" nucleoside therapeutics against virus infection and cancer, his special interest has shifted to immuno therapeutics.

近期论文

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Vladimir Pliska, Gerd Folkers, Vojtech Spiwok, Thermodynamics of the interaction between oxytocin and its myometrial receptor in sheep: A stepwise binding mechanism Biochemical Pharmacology 91 (2014) 119–127 Karin Landolt, Amrei Wittwer, Thomas Wyss, Lui Unterassner, Wolfgang Fach, Peter Krummenacher, Peter Brugger, Helene Haker, Wolfram Kawohl, Pius August Schubiger, Gerd Folkers and Wulf Rössler, Help-seeking in people with exceptional experiences: results from a general population sample. Front. Public Health, 21 May 2014 | doi:10.3389/fpubh.2014.00051 H. Atmanspacher, L. Bezzola Lambert, G. Folkers and P. A. Schubiger, Relevance relations for the concept of reproducibility. J. R. Soc. Interface 2014 11, 20131030. Gerd Folkers, Economization in Science and of Science itself: Changes to the Game, Swiss Science and Technology Council Report 4/2013, 42-44, 2013 Gerd Folkers, Freiheit in der Forschung, Die Pharmazie 7, An International Journal of Pharmaceutical Sciences, Volume 68, July 2013 Peter Krummenacher, Elvan Kut, Gerd Folkers, Peter Brugger. Naloxone modulates visual judgments of similarity but not dissimilarity. Cognitive, Affective, & Behavioral Neuroscience, March 2013, DOI 10.3758/s13415-013-0155-9 V. Pliska, G. Folkers, Chemistry and chemists in the story of insulin [Inzulín:chemie achemici v jeho historii], Diabetologie Metabolismus Endokrinologie Vyziva 15 (2), pp. 111– Schaffner N, Folkers G, Käppeli S, Musholt M, Hofbauer GFL, et al. (2012) A New Tool for Real-Time Pain Assessment in Experimental and Clinical Environments. PLoS ONE 7(11):e51014. doi:10.1371/journal.pone.0051014 Gerd Folkers, Protein-Protein-Interactions, Preface. Methods in Medicinal Chemistry Wiley-VCH, 2012 Gerd Folkers, Wissenschaft in Gefahr "Den Fressnapf der Forscher verschoben" Spiegel-Online, 10.10.2012 http://www.spiegel.de/wissenschaft/medizin/forschung-warum-derutilitarismus-die-freiheit-der-forschung-bedroht-a-860141.html Gerd Folkers. On future challenges of global Pharma. What are the core issues, role models and how to find or educate people with the right competencies? A synopsis of the panel discussion. SWISS PHARMA 34 (2012) s. 37 - 39 Gerd Folkers, Drug Design and Emotion SWISS PHARMA 33 (2011) S. 11 - 14 Gerd Folkers: Duchamp und die Poincaré-Vermutung, In: Margarete Jarchow (Hg.), Kreativität in Gestaltungsprozessen, Schriften des Graduiertenkollegs – KUNST UND TECHNIK, Band 3, Neumünster 2011, S. 111–130. Gerd Folkers, Samuel Zinsli: Bildeffekte in wissenschaftstheoretischer Perspektive In: Präsenz im Entzug – Ambivalenzen des Bildes, hg. von Philipp Stoellger und Thomas Klie, Mohr Siebeck 2011. Wulf Rössler, Gerd Folkers, Der Patient im Mittelpunkt – das Geld im Vordergrund, Schweizerische Ärztezeitung, 2011;92: 48, 1881–1883 Elvan Kut, Victor Candia, Jan von Overbeck, Judit Pok, Daniel Fink, Gerd Folkers Pleasure-Related Analgesia Activates Opioid-Insensitive Circuits, The Journal of Neuroscience, 2011, 31, 4148-4153; Jair Stern, Victor Candia, Roseline I. Porchet, Peter Krummenacher, Gerd Folkers, Manfred Schedlowski, Dominik A. Ettlin, Georg Schönbächler: Placebo-mediated, Naloxone-sensitive suggestibility of short-term memory performance, Neurobiology of Learning and Memory, 2011, 95, 326-334 M. Kusserow, G. Tröster, V. Candia, G. Folkers, O. Amft, H. Hildebrandt, Wearable. monitoring of stage fright in professional musicians, Wearable Computers (ISWC), 2010 International Symposium, 10-13 Oct. 2010, DOI: 10.1109/ISWC.2010.5665852 Gerd Folkers, Elvan Kut, and Martin Boyer. Drug Design: Designer Drugs. In: S. Konsorski-Lang and M. Hampe (Hrsg.) The Design of Material, Organism, and Minds, Springer Berlin, Heidelberg 2010. S. 53-63 Gerd Folkers. Roadside Picnic – From Anthropocentrism to Anthropomorphism, an Attitude for Human Survival, or How to Make you Feel at Home in Universe. In: Folkers, Gerd/Boyer, Martin/ Vychitil, Pavel/ Pliska, Vladimir (Hrsgg.): The Role of Anthropocentrism in Science. 11th Villa Lanna Meeting on «Science, or Else?», Prague, January 16–18, 2009, Zürich 2010 (= Collegium Helveticum Heft ; 10), S.43-54