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个人简介

2007.09 - 2010.06,上海师范大学微生物学专业,理学硕士学位。 2018.08 - 2019.06,中国科学院大学高分子化学与物理专业,获理学博士学位。 2010.06 - 2012.09,中国科学院宁波材料技术与工程研究所,科研助理。 2012.09 - 2018.12,宁波材料技术与工程研究所,助理研究员。 2018.12 - 至今,宁波材料技术与工程研究所,高级工程师。 主要从事基于纳米探针的恶性肿瘤、心脑血管疾病诊断与治疗研究、无极-有机复合抗菌材料研究。目前,主持浙江省公益计划项目1项,主持完成浙江省自然科学基金1 项、宁波市自然科学基金1项、中科院重点实验室开放课题1项;以骨干或主要成员身份参与多项国家自然科学基金项目、中科院重点部署项目、浙江省重点研发计划等。已在ACS Nano、Biomaterials、Nanoscale、Advanced Healthcare Materuals、Biomaterials Science等国际权威期刊发表 SCI论文30余篇,其中第一/通讯作者SCI论文8篇;申请中国发明专利10余项,PCT专利1项,其中第一发明设计人5项、获授权5项。 主持项目: 中空黑TiO2纳米探针的构建及其HIFU增效精准治疗肝癌研究. 浙江省自然科学基金,2019.01-2021.12 10万 近红外光激发黑TiO2纳米粒子的肿瘤光热治疗与药物控释研究.浙江省自然科学基金,2015.01-2017.12 8万 叶酸偶联的超顺磁Fe3O4-TiO2纳米粒子用于恶性肿瘤的MRI早期诊断与声动力治疗研究.宁波市自然科学基金,2014.03-2016.02 3万 专著 Aiguo Wu; Wenzhi Ren; TiO2 Nanoparticles:Applications in Nanobiotechnology and Nanomedicine. WILEY-VCH, 2020. 已申请或授权的主要专利: 任文智,吴爱国,一种基于纳米粒子的肿瘤细胞主动靶向给药体系及其构建方法,授权号:ZL201110397312.7 任文智,吴爱国,曾乐勇,沈折玉,马雪华,三元纳米复合药物、其制备方法和其用于制备治疗肿瘤的药学组合物的用途,授权号:ZL201310103775.7 任文智,吴爱国,一种肿瘤治疗复合纳米材料及其制备,授权号:ZL201410175018.5 任文智,吴爱国,马雪华,陈天翔,张涛,一种纳米复合材料、其制备方法及在HIFU增效剂中的应用,申请号:201810429878.5 吴爱国, 任文智, 邹瑞芬,一种纳米复合材料及其在示踪淋巴结中的应用,申请号:201710092810.8 沈折玉,吴爱国,任文智,马雪华,主动靶向性小干扰核糖核酸输送载体及其制备方法,授权号:ZL201210475752.4 张涛,吴爱国,任文智,蒋振奇,薛婷,马雪华,一种纳米复合材料、其制备方法及应用,专利申请号:201810907829.8

研究领域

基于纳米探针的重大疾病早期诊断与治疗研究。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Tao Zhang#, Zhenqi Jiang#, Libin Chen#, Chunshu Pan, Shan Sun, Chuang Liu, Zihou Li, Wenzhi Ren*, Aiguo Wu*, Pintong Huang*.PCN-Fe(III)-PTX nanoparticles for MRI guided high efficiency chemo-photodynamic therapy in pancreatic cancer through alleviating tumor hypoxia, Nano Research, 2020, 13: 273-281. Jie Lin#, Wenzhi Ren#, Anran Li#, Chenyang Yao, Tianxiang Chen, Xuehua Ma, Xiaotian Wang*, Aiguo Wu*, Crystal-amorphous core-shell structure synergistically enabling TiO2 nanoparticles’ remarkable SERS sensitivity for cancer cell imaging, ACS Appl. Mater. Interfaces, 2020, 12: 4204-4211. (#co-first author) Siqi Wang#, Wenzhi Ren#, Jianhua Wang,* Zhenqi Jiang, Madiha Saeed, Lili Zhang, Aiguo Li, Aiguo Wu*. Black TiO2-based nanoprobes for T1-weighted MRI-guided photothermal therapy in CD133 high expressed pancreatic cancer stem-like cells. Biomater. Sci., 2018, 6: 2209-2218. Madiha Saeed#, Wenzhi Ren#, Aiguo Wu. Therapeutic applications of iron oxide based nanoparticles in cancer: basic concepts and recent advances. Biomater. Sci., 2018, 6, 708-725. Wenzhi Ren, M. Zubair Iqbal, Leyong Zeng, Tianxiang Chen, Yuanwei Pan, Jinshun Zhao, Hao Yin, Lili Zhang, Jichao Zhang, Aiguo Li, Aiguo Wu*, Black TiO2 based core–shell nanocomposites as doxorubicin carriers for thermal imaging guided synergistic therapy of breast cancer, Nanoscale, 2017, 9: 11195-1120. Wenzhi Ren#, Yong Yan#, Leyong Zeng, Zhenzhi Shi, An Gong, Peter Schaaf, Dong Wang*, Jinshun Zhao, Baobo Zou, Hongsheng Yu, Ge Chen*, Eric Michael Bratsolias Brown, and Aiguo Wu*. A near infrared light triggered hydrogenated black TiO2 for cancer photothermal therapy. Adv. Healthcare Mater., 2015, ,4, 1526–1536. (back cover;cited 100+ in Google Scholar ) Yang Du#, Wenzhi Ren#, Yaqian Li, Qian Zhang, Leyong Zeng, Chongwei Chi, Aiguo Wu*, Jie Tian*. The enhanced chemotherapeutic effects of doxorubicin loaded PEG coated TiO2 nanocarriers in an orthotopic breast Tumor bearing mouse model. Journal of Materials Chemistry B, 2015, 3, 1518-1528. (#co-first author; 2015 Journal of Materials Chemistry B Hot Papers) Wenzhi Ren, Leyong Zeng, Zheyu Shen, Lingchao Xiang, An Gong, Jichao Zhang, Chengwen Mao, Aiguo Li, Tatjana Paunesu, Gayle E. Woloschak, Narayan S. Hosmane, Aiguo Wu*. Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers, RSC Advances, 2013, 3: 20855-20861 M. Zubair Iqbal, Wenzhi Ren, Madiha Saeed, Tianxiang Chen, Xuehua Ma, Xu Yu, Jichao Zhang, Lili Zhang, Aiguo Li, Aiguo Wu*. A facile fabrication route for binary transition metal oxide-based Janus nanoparticles for cancer theranostic applications. Nano research, 2018, 11, 5735-5750. Zhenzhi Shi, Wenzhi Ren, An Gong, Xinmei Zhao, Yuehong Zou, Eric Michael Bratsolias Brown, Xiaoyuan Chen, Aiguo Wu*, Stability enhanced polyelectrolyte-coated gold nanorod-photosensitizer complexes for high/low power density photodynamic therapy, Biomaterials, 2014, 35: 7058-7067

学术兼职

是中国生物物理学会会员、中国抗癌协会会员。

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