个人简介

Michael Detmar has been Full Professor of Pharmacogenomics in the Institute of Pharmaceutical Sciences since September 2004. Professsor Detmar was born in Stuttgart, Germany in 1957. He studied medicine in Freiburg and Vienna and obtained a M.D. degree in 1984 from the University of Freiburg. He trained in pathology at the University of Freiburg from 1984 to 1985, and completed a residency in dermatology at the Free University of Berlin in 1990. In 1991, he completed his habilitation and then served for 2 years as an assistant professor of dermatology at the Free University of Berlin. From 1993 to 1997, he was appointed visiting professor of pathology and dermatology at Harvard Medical School in Boston, USA. Since 1998, he holds an appointment as associate professor at Harvard Medical School, and he also served as an associate director of research at the Department of Dermatology, Massachusetts General Hospital. He is the recipient of several awards, most recently of the year 2005 Marion B. Sulzberger Memorial Award and Lectureship of the American Academy of Dermatology. He serves as an associate editor of several scientific journals including Cancer Research, Cancer Biology and Therapy, and The Journal of Investigative Dermatology, and he also serves on the advisory boards of several international institutions and companies.

研究领域

Pharmacogenomics

His research program focuses on cancer biology, in particular the role of angiogenesis and lymphangiogenesis towards tumor metastasis, as well as on the molecular control of chronic inflammation. A major focus of the group is the genetic disposition for disease and for the response to specific therapies, with the aim to develop new individualized therapies for human diseases.

近期论文

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Hemmerle, Teresa and Zgraggen, Silvana and Matasci, Mattia and Halin, Cornelia and Detmar, Michael and Neri, Dario Antibody-mediated delivery of interleukin 4 to the neo-vasculature reduces chronic skin inflammation 2014, Journal of Dermatological Science Bianchi, Roberta and Fischer, Eliane and Yuen, Don and Ernst, Ellen and Ochsenbein, Alexandra M. and Chen, Lu and Otto Vivianne I. and Detmar, Michael Mutation of Threonine 34 in Mouse Podoplanin-Fc Reduces CLEC-2 Binding and Toxicity in Vivo While Retaining Anti-lymphangiogenic Activity 2014, The Journal of Biological Chemistry He, Jingjing and Sinues, Pablo M.L. and Hollmén, Maija and Li, Xue and Detmar, Michael and Zenobi, Renato Fingerprinting breast cancer vs. normal mammary cells by mass spectrometric analysis of volatiles 2014, Scientific Reports Kunstfeld, Rainer and Hawighorst, Thomas and Streit, Michael and Hong, Young-Kwon and Nguyen, Lynh and Brown, Lawrence F. and Detmar, Michael Thrombospondin-2 overexpression in the skin of transgenic mice reduces the susceptibility to chemically induced multistep skin carcinogenesis 2014, Journal of Dermatological Science Katrin S. Blum, and Karaman, Sinem and Proulx, Steven T. and Ochsenbein, Alexandra M. and Luciani, Paola and Leroux, Jean-Christophe and Wolfrum, Christian and Detmar, Michael Chronic high-fat diet impairs collecting lymphatic vessel function in mice 2014, PLoS ONE Dieterich, Lothar C. and Seidel, Catharina D. and Detmar, Michael Lymphatic vessels 2014, Angiogenesis Zgraggen, Silvana and Huggenberger, Reto and Kerl, Katrin and Detmar, Michael An important role of the SDF-1/CXCR4 axis in chronic skin inflammation 2014, PLoS ONE Hirakawa, Satoshi and Detmar, Michael and Karaman, Sinem Lymphatics in nanophysiology 2014, Advanced Drug Delivery Reviews FANTOM Consortium and the RIKEN PMI and CLST (DGT) and Forrest, Alistair and Detmar, Michael and Krampitz, Sarah A promoter-level mammalian expression atlas 2014, Nature Karaman, Sinem and Detmar, Michael Mechanisms of lymphatic metastasis 2014, Journal of Clinical Investigation Ochsenbein, Alexandra M. and Karaman, Sinem and Jurisic, Giorgia and Detmar, Michael The Role of Neuropilin-1/Semaphorin 3A Signaling in Lymphatic Vessel Development and Maturation 2014, Advances in anatomy, embryology and cell biology Ochsenbein, Alexandra M. and Karaman, Sinem and Jurisic, Giorgia and Detmar, Michael The Role of Neuropilin-1/Semaphorin 3A Signaling in Lymphatic Vessel Development and Maturation 2014, Advances in Anatomy, Embryology and Cell Biology Proulx, Steven T. and Dieterich, Lothar C. and Karaman, Sinem and Leroux, Jean-Christophe and Detmar, Michael Expansion of the lymphatic vasculature in cancer and inflammation 2013, Journal of Controlled Release Rodrigues, Tiago and Kudoh, Takayuki and Roudnicky, Filip and Lim, Yi Fan and Lin, Yen-Chu and Koch, Christian P. and Seno, Masaharu and Detmar, Michael and Schneider, Gisbert Steering target selectivity and potency by fragment-based de novo drug design 2013, Angewandte Chemie. International edition in English Alitalo, Annamari K. and Proulx, Steven T. and Karaman, Sinem and Aebischer, David and Martino, Stefania and Jost, Manuela and Schneider, Nicole and Bry, Maija and Detmar, Michael VEGF-C and VEGF-D Blockade Inhibits Inflammatory Skin Carcinogenesis 2013, Cancer Research Proulx, Steven T. and Detmar, Michael Molecular mechanisms and imaging of lymphatic metastasis 2013, Experimental Cell Research Proulx, Steven T. and Luciani, Paola and Alitalo, Annamari and Mumprecht, Viviane and Christiansen, Alisa J. and Huggenberger, Reto and Leroux, Jean-Christophe and Detmar, Michael Non-invasive dynamic near-infrared imaging and quantification of vascular leakage in vivo 2013, Angiogenesis Proulx, Steven T. and Luciani, Paola and Christiansen, Ailsa and Karaman, Sinem and Blum, Katrin S. and Rinderknecht, Matthias and Leroux, Jean-Christophe and Detmar, Michael Use of a PEG-conjugated bright near-infrared dye for functional imaging of rerouting of tumor lymphatic drainage after sentinel lymph node metastasis 2013, Biomaterials Proulx, Steven T. and Luciani, Paola and Christiansen, Alisa and Karaman, Sinem and Blum, Katrin S. and Rinderknecht, Matthias and Leroux, Jean-Christophe and Detmar, Michael Use of a PEG-conjugated bright near-infrared dye for functional imaging of rerouting of tumor lymphatic drainage after sentinel lymph node metastasis 2013, Biomaterials Blum, Katrin S. and Proulx, Steven T. and Luciani, Paola and Leroux, Jean-Christophe and Detmar, Michael Dynamics of lymphatic regeneration and flow patterns after lymph node dissection 2013, Breast Cancer Research and Treatment