张志刚 - 南京工业大学

个人简介

2010年毕业于中国科学院成都生物研究所环境科学专业，获理学博士学位，2011年1月赴德国马普煤炭研究所（Max-Planck-Institut für Kohlenforschung）从事博士后研究工作，合作导师为Manfred T. Reetz。2014年10月赴美国亚利桑那州立大学生物设计研究所（Biodesign Institute，ASU）从事博后研究工作。2015年12月回国，在南京工业大学药学院工作

研究领域

酶的定向进化和 (半) 理性设计；酶结构与功能关系；合成生物学；精细化学品、重要手性医药中间体的酶催化合

近期论文

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Zhang, Z.-G., Lonsdale, R., Sanchis, J., Reetz, M. T*(2014) Extreme Synergistic Mutational Effects in the Directed Evolution of a Baeyer–Villiger Monooxygenase as Catalyst for Asymmetric Sulfoxidation. J. Am. Chem. Soc. 136, 17262−17272. This work was also spotlighted in JACS! Zhang, Z.-G., Roiban, G.-D., Acevedo, J. P., Polyak, I. and Reetz, M. T*. (2013), A New Type of Stereoselectivity in Baeyer–Villiger Reactions: Access to E- and Z-Olefins. Adv. Synth. Catal., 355: 99–106. Zhang, Z.-G., Parra, L. P. and Reetz, M. T*. (2012), Protein Engineering of Stereoselective Baeyer–Villiger Monooxygenases. Chem. Eur. J., 18: 10160–10172. Zhang, Z.-G., Yi, Z. L., Pei, X. Q., & Wu, Z.-L*. (2010). Improving the thermostability of Geobacillus stearothermophilus xylanase XT6 by directed evolution and site-directed mutagenesis. Bioresource Technology, 101, 9272–9278. Zhang, Z.-G., Liu, Y., Guengerich, F.P., Matse, J.H., Chen J., Wu, Z.-L.* (2009) Identification of amino acid residues involved in 4-chloroindole 3-hydroxylation by cytochrome P450 2A6 using screening of random libraries. J. Biotechnol. 139(1), 12-18. Zhang Z.-G, Zhao Y., Zhang C.-X, Bian S.-M, Zhou H.-N, Wang H.-P, Yin H., Huang, J.-F*. (2006), Characterization of a nitrogenase CrFe protein from a mutant UW3 of Azotobacter vinelandii grown on a Cr-containing medium. Chin Sci Bul 51 (14), 1729-1735