个人简介
招生专业
070703-海洋生物学
招生方向
海洋药物与制品
教育背景
2008-09--2011-07 中国科学院大学 博士
2005-09--2008-06 中国农业科学院 硕士
工作简历
2016-03~2017-03,Stony Brook University, 访问学者
2013-12~现在, 中国科学院海洋研究所, 副研究员
2011-07~2013-12,中国科学院海洋研究所, 助理研究员
2008-09~2011-07,中国科学院大学, 博士
2005-09~2008-06,中国农业科学院, 硕士
专利成果
( 1 ) 一种微小RNA纳米微球的制备及其在抗肿瘤方面的应用, 2014, 第 2 作者, 专利号: CN104436217A
( 2 ) 九种PTPlB抑制剂及其合成和应用, 2015, 第 4 作者, 专利号: ZL 201510278442.7
( 3 ) 一种玻璃海鞘多肽的应用, 2010, 第 4 作者, 专利号: ZL201010620667.3
( 4 ) 一种链酶亲和素结合功能荧光磁性纳米颗粒的应用, 2010, 第 3 作者, 专利号: ZL201010622840.3
( 5 ) 一种嗜盐曲霉菌F1及其应用, 2011, 第 3 作者, 专利号: ZL201110356217.2
科研项目
( 1 ) 基于SRC通路研究 BPN靶向PTP1B抑制 神经胶质瘤生长的分 子机制, 主持, 国家级, 2019-01--2022-12
( 2 ) 褐藻多糖硫酸脂改善新型冠状病毒导致的肺损伤及抗病毒双重作用研究, 主持, 国家级, 2020-06--2021-05
( 3 ) 海洋来源的多肽CSP 靶向ENO1抑制肿瘤 生长和转移的分子机制, 主持, 国家级, 2014-01--2016-12
( 4 ) 抗肿瘤新药海鞘多肽CS5931的研制与开发, 主持, 国家级, 2014-01--2016-12
( 5 ) 新型抗肿瘤候选海鞘GRN多肽靶向STAT3抑制肿瘤干细胞自我更新和肿瘤血管生成拟态的分子机制, 主持, 省级, 2016-01--2017-12
( 6 ) 抗肿瘤海洋多肽Mere15的制备及功能结构域鉴定, 主持, 省级, 2014-12--2017-12
参与会议
(1)Protein tyrosine phosphatase 1B is a new therapy target of Pancreatic cancer 2019医学前沿论坛暨第十六届全国肿瘤药理与临床化疗学术会议 2019-04-17
(2)Zinc-doped copper oxide nanocomposites reverse temozolomide resistance in glioblastoma by inhibiting AKT and ERK1/2 全国肿瘤大会 2018-08-17
(3)microRNA 调控神经胶质瘤干细胞增殖和分化的分子机制 全国肿瘤大会 2012-08-18
(4)Role of MicroRNA-26b in Glioma Development and Its Mediated Regulation on EphA2 第十二届全国肿瘤药理与化疗会议 2011-04-24
近期论文
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(1) Comparative Study of Fucoidan from Saccharina japonica and Its Depolymerized Fragment on Adriamycin-Induced Nephrotic Syndrome in Rats., Marine Drugs, 2020, 第 5 作者
(2) A tropomyosin-like Meretrix meretrix Linnaeus polypeptide inhibits the proliferation and metastasis of glioma cells via microtubule polymerization and FAK/Akt/MMPs signaling., International Journal of Biological Macromolecules, 2020, 通讯作者
(3) Degradation of different molecular weight fucoidans and their inhibition of TGF-β1 induced epithelial–mesenchymal transition in mouse renal tubular epithelial cells., Int J Biol Macromol., 2020, 第 2 作者
(4) Inhibition of PTP1B suppresses pancreatic cancer progression via activation of AMPK., Cell death and disease, 2019, 第 1 作者
(5) H1, a derivative of tetrandrine, enhances the efficacy of 5-FU in Bel7402/5-FU cells via suppressing STAT3/MCL-1 and inducing PUMA, Biochemical and Biophysical Research Communications, 2019, 第 3 作者
(6) Zinc-Doped Copper Oxide Nanocomposites reverse Temozolomide resistance in Glioblastoma by inhibits AKT and ERK1/2., Nanomedicine, 2018, 第 1 作者
(7) BPN, a marine-derived PTP1B inhibitor, activates insulin signaling andimproves insulin resistance in C2C12 myotubes, International Journal of Biological Macromolecules, 2017, 第 3 作者
(8) Development of novel miR-129 mimics with enhanced efficacy to eliminate chemoresistant colon cancer stem cells., Oncotarget., 2017, 第 1 作者
(9) Autophagy regulated by miRNAs in colorectal cancer progression and resistance, Cancer Transl Med., 2017, 第 3 作者
(10) Stable and Biocompatible Colloidal Dispersions of Superparamagnetic Iron Oxide Nanoparticles with Minimum Aggregation for Biomedical Applications, Journal of Physical Chemistry C, 2017, 第 4 作者
(11) BPN, a marine-derived PTP1B inhibitor, activates insulin signaling andimproves insulin resistance in C2C12 myotubes, International Journal of Biological Macromolecules, 2017, 第 3 作者
(12) Interaction between granulin A and enolase 1 attenuates the migration and invasion of human hepatoma cells., Oncotarget., 2017, 第 3 作者
(13) In Vitro Studies of Polyethyleneimine coated miRNA Nano Microspheres as Anticancer Agent., Nano Research, 2016, 第 1 作者
(14) Small Molecules as Potent Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors Documented in Patents from 2009 to 2013, Mini Reviews in Medicinal Chemistry, 2015, 第 3 作者
(15) Marine Bromophenol Bis (2,3-Dibromo-4,5-dihydroxy-phenyl)-methane Inhibits the Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells via Modulating β1-Integrin/FAK Signaling, Marine Drugs, 2015, 第 1 作者
(16) Cardamonin induces apoptosis by suppressing STAT3 signaling pathway in glioblastoma stem cells, Tumor Biology, 2015, 第 1 作者
(17) Marine Bromophenol Derivative 3,4-Dibromo-5- (2-bromo-3,4-dihydroxy-6--isopropoxymethyl benzyl)benzene-1,2-diol Protects Hepatocytes from Lipid-Induced Cell Damage and Insulin Resistance via PTP1B Inhibition,, Marine Drugs, 2015, 第 2 作者
(18) Natural and semisynthetic protein tyrosine phosphatase 1B (PTP1B) inhibitors as anti-diabetic agents, RSC Advances, 2015, 第 3 作者
(19) plysin Sensitizes Cancer Cells to TRAIL by Suppressing P38 MAPK/Survivin Pathway, Marine Drugs, 2014, 第 3 作者
(20) Oleanolic Acid Suppresses Aerobic Glycolysis in Cancer Cells by Switching Pyruvate Kinase Type M Isoforms,, PLos One, 2014, 第 1 作者
(21) Oleanolic Acid Suppresses Aerobic Glycolysis in Cancer Cells by Switching Pyruvate Kinase Type M Isoforms,, PLos One, 2014, 第 1 作者
(22) Oleanolic Acid Induces Metabolic Adaptation in Cancer Cells by Activating the AMP-Activated Protein Kinase Pathway, Journal of Agricultural and Food Chemistry, 2014, 第 1 作者
(23) p38 MAPK Signaling Mediates Mitochondrial Apoptosis in Cancer Cells Induced by Oleanolic Acid, Asian Pacific Journal of Cancer Prevention, 2014, 第 1 作者
(24) MiR-125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK-independent pathways, British Journal of Cancer,, 2013, 第 1 作者
(25) A novel protein from Eupolyphaga sinensis inhibits adhesion, migration, and invasion of human lung cancer A549 cells, BIOCHEM AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 2013, 第 2 作者
(26) argeting cellular apoptotic pathway with peptides from marine organisms, BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2013, 第 3 作者
(27) miR-125b regulates the proliferation of glioblastoma stem cells by targeting E2F2, FEBS Letters, 2012, 第 1 作者
(28) Effective Silencing of Sry Gene with RNA Interference in Developing Mouse Embryos Resulted in Feminization of XY Gonad, Journal of Biomedicine and Biotechnology, 2012, 第 1 作者
(29) Zebrafish p53 protein enhances the translation of its own mRNA in response to UV irradiation and CPT treatment, FEBS Letters, 2012, 第 2 作者
(30) Role of MicroRNA-26b in Glioma Development and Its Mediated Regulation on EphA2, PLos One, 2011, 第 1 作者
学术兼职
2018-08-01-今,中国抗癌协会抗肿瘤药物专业委员会青年委员, 青年委员