研究领域

Synthesis & Chemical Biology

Research in our group seeks to bring the experience and tactics of natural product total synthesis and the strategies of organic methodology development to bear on contemporary problems in reaction discovery, molecular biology, and materials science. Although the synthesis of organic molecules remains the cornerstone of our approach, we believe the molecules and methods developed in our laboratory will have wide ranging applications in emerging areas.

近期论文

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(106) Noda, H.; Bode, J. W. "Synthesis of Chemically and Configurationally Stable Monofluoro Acylboronates: Effect of Ligand Structure on their Formation, Properties and Reactivities", J. Am. Chem. Soc. 2015, ASAP. Link (DOI: 10.1021/jacs.5b00822) Harmand, T. J.; Kulkarni, S. S.; Bode, J. W. "Optimized Synthesis of a Cyanosulfurylide Linker for Fmoc-SPPS of C-Terminal Peptide α-Ketoacids", Tetrahedron Lett. 2015, ASAP. Link (DOI: 10.1016/j.tetlet.2015.01.048) Saito, F.; Noda, H.; Bode, J. W. "Critical evaluation and rate constants of chemoselective ligation reactions for stoichiometric conjugations in water", ACS Chem. Biol. 2015, ASAP. Link (DOI: 10.1021/cb5006728) Murar, C. E.; Thuaud, F.; Bode, J. W. "KAHA Ligations that form Aspartyl Aldehyde Residues as Synthetic Handles for Protein Modification and Purification", J. Am. Chem. Soc. 2014, 136, 18140–18148. Link Siau, W.-Y.; Bode, J. W. "One Step Synthesis of Saturated Spirocyclic N-Heterocycles with SnAP Reagents and Ketones", J. Am. Chem. Soc. 2014, 136, 17726–17729. Link Review article: Harmand, T. J. R.; Murar, C. E.; Bode, J. W. "New chemistries for chemoselective peptide ligations and the total synthesis of proteins", Curr. Opin. Chem. Biol. 2014, 22, 115–121. Link Wucherpfennig, T. G.; Pattabiraman, V. R.; Limberg, F. R. P.; Ruiz-Rodríguez, J.; Bode, J. W. "Traceless Preparation of C-Terminal α-Ketoacids for Chemical Protein Synthesis by α-Ketoacid–Hydroxylamine Ligation: Synthesis of SUMO2/3", Angew. Chem. Int. Ed. 2014, 53, 12248–12252. Link Wucherpfennig, T. G.; Rohrbacher, F.; Pattabiraman, V. R.; Bode, J. W. "Formation and Rearrangement of Homoserine Depsipeptides and Depsiproteins in the α-Ketoacid–Hydroxylamine Ligation with 5-Oxaproline", Angew. Chem. Int. Ed. 2014, 53, 12244–12247. Link Huang, Y.-L.; Bode, J. W. "Synthetic fermentation of bioactive non-ribosomal peptides without organisms, enzymes or reagents", Nature Chem. 2014, 6, 877–884. Link - Interview: Nature Chem. 2014, 6, 846–847. Link Schäfer, G.; Leu, L.; Bode, J. W. "Synthesis of Unsymmetrical, gem-Disubstituted Bisamides", Heterocycles 2015, 90, 1375–1386. (Special issue) Link Allen, S. E.; Hsieh, S.-Y.; Gutierrez, O.; Bode, J. W.; Kozlowski, M. C. "Concerted Amidation of Activated Esters: Reaction Path and Origins of Selectivity in the Kinetic Resolution of Cyclic Amines via NHC and Hydroxamic Acid Co-Catalyzed Acyl Transfer", J. Am. Chem. Soc. 2014, 136, 11783–11791. Link Erős, G.; Kushida, Y.; Bode, J. W. "A Reagent for the One-Step Preparation of Potassium Acyltrifluoroborates (KATs) from Aryl- and Heteroarylhalides", Angew. Chem. Int. Ed. 2014, 53, 7604–7607. Link Hsieh, S.-Y.; Bode, J. W. "(4aR,9aS)-4-Hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one", e-EROS 2014, Published Online. Link (DOI: 10.1002/047084289X.rn01654) Noda, H.; Bode, J. W. "Synthesis and Chemoselective Ligations of MIDA Acylboronates with O-Me Hydroxylamines", Chem. Sci. 2014, 5, 4328–4332. Link Hsieh, S.-Y.; Wanner, B.; Wheeler, P.; Beauchemin, A. M.; Rovis, T; Bode, J. W. "Stereoelectronic Basis for the Kinetic Resolution of N-Heterocycles with Chiral Acylating Reagents", Chem. Eur. J. 2014, 20, 7228–7231. Link Schäfer, G.; Bode, J. W. "The Synthesis of Sterically Hindered Amides", CHIMIA 2014, 68, 252–255. Link Noda, H; Erős, G; Bode, J. W. "Rapid Ligations with Equimolar Reactants in Water with the Potassium Acyltrifluoroborate (KAT) Amide-Formation", J. Am. Chem. Soc. 2014, 136, 5611–5614. Link Review article: Vo, C.-V.; Bode, J. W. "Synthesis of Saturated N-Heterocycles", J. Org. Chem. 2014, 79, 2809–2815. Link Schäfer, G.; Bode, J. W. "Synthesis of Sterically Hindered N-Acylated Amino Acids from N-Carboxyanhydrides", Org. Lett. 2014, 16, 1526–1529. Link Vo, C.-V.; Luescher, M. U.; Bode, J. W. "SnAP Reagents for the One-Step Synthesis of Medium Ring Saturated N-Heterocycles from Aldehydes", Nature Chem. 2014, 6, 310–314. Link