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Synthesis and Antimicrobial Activity of 2,1'-Dihydropyridomycins Horlacher, O.P.; Hartkoorn, R. C.; Cole, S. T.; Altmann, K.-H. ACS Medicinal Chemistry Letters, Ahead of Print.
Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents. Prota AE, Bargsten K, Zurwerra D, Field JJ, Díaz JF, Altmann KH, Steinmetz MO.
Science. 2013 Jan 3. [Epub ahead of print]
Total Synthesis of (-)-Zampanolide and Structure-Activity Relationship Studies on (-)-Dactylolide Derivatives Zurwerra, D.; Glaus, F.; Betschart, L.; Schuster, J.; Gertsch, J.; Ganci, W.; Altmann, K.-H. Chemistry, 2012, 18(52), 16868-16883.
Towards a new Tuberculosis Drug: Pyridomycin - Nature's Isoniazid Hartkoorn, R. C.; Sala, C.; Neres, J.; Pojer, F.; Magnet, S.; Mukherjee, R.; Uplekar, S.; Boy-Roettger, S.; Altmann, K.-H.; Cole, S. T. EMBO Molecular Medicine (2012), 4(10), 1032-1042.
Zampanolide, a Potent New Microtubule-Stabilizing Agent, Covalently Reacts with the Taxane Luminal Site in Tubulin α,β-Heterodimers and Microtubules Field, J. J.; Pera, B.; Calvo, E.; Canales, A.; Zurwerra, D.; Trigili, C.; Rodriguez-Salarichs, J.; Matesanz, R.; Kanakkanthara, A.; Wakefield St. J.; Singh A. J.; Jimenez-Barbero, J.; Northcote, P.; Miller, J. H.; Lopez, J. A.; Hamel, E.; Barasoain, I.; Altmann, K.-H.; Diaz, J.F. Chemistry & Biology (Oxford, United Kingdom) (2012), 19(6), 686-698.
Probing the Bioactivity-Relevant Chemical Space of Robust Reactions and Common Molecular Building Blocks Hartenfeller, M.; Eberle, M.; Meier, P.; Nieto-Oberhuber, C.; Altmann, K.-H.; Schneider, G.; Jacoby, E.; Renner, S. Journal of Chemical Information and Modeling (2012), 52(5), 1167-1178.
Immunosuppressiv Small Molecule Discovered by Structure-Based Virtual Screening for Inhibitors of Protein-Protein Interactions Geppert, T.; Bauer, S.; Hiss, J. A.; Conrad, E.; Reutlinger, M.; Schneider, P.; Weisel, M.; Pfeiffer, B.; Altmann, K.-H.; Waibler, Z.; Schneider, G. Angewandte Chemie, International Edition, 2012, 51(1), 258-261.
A Ring-Closing Metathesis-Based Approach to the Synthesis of (+)-Tetrabenazine Johannes M.; Altmann K.-H. Organic Letters, 2012, 14(14), 3752-3755.
Total Synthesis of the bacterial RNA polymerase inhibitor ripostatin B. Glaus F.; Altmann K.-H. Angewandte Chemie (International ed. in English), 2012, 51(14), 3405-9.
A Collection of Robust Organic Synthesis Reactions for In Silico Molecule Design Hartenfeller, M.; Eberle, M.; Meier, P.; Nieto-Oberhuber, C.; Altmann, K.-H.; Schneider, G.; Jacoby, E.; Renner, S. Journal of Chemical Information and Modeling, 2011, 51(12), 3093-3098.
Ginger Phenylpropanoids Inhibut IL-1β and Prostanoid Secretion and Disrupt Arachidonate-PHospholipid Remodelling by Targeting Phospholipases A2 Nievergelt, A.; Marazzi, J.; Schoop, R.; Altmann, K.-H.; Gertsch, J. Journal of Immunology, 2011, 187(8), 4140-4150.
Mechanisms of Osteoclastogenesis Inhibition by a Novel Class of Biphenyl-Type Cannabinoid CB2 Receptor Inverse Agonists Schuehly, W.; Paredes, J. M. V.; Kleyer, J.; Huefner, A.; Anavi-Goffer, S.; Raduner, S.; Altmann, K.-H.; Gertsch, J. Chemistry & Biology, 2011, 18(8), 1053-1064.
Diversity through semisynthesis: the chemistry and biological activity of semisynthetic epothilone derivatives. Altmann, K.-H., Gaugaz, F. Z., Schiess, R. Mol.Divers. 2011, 15, 383-399.
Stereoselective Synthesis of 12,13-Cyclopropyl-Epothilone B and Side-Chain-Modified Variants. R. Schiess, R., Gertsch, J., Schweizer, W. B., Altmann. K.-H. Org. Lett., 2011, 13, 1436-1439.
Kinase Inhibition by Deoxy Analogs of the Resorcylic Lactone L-783277. Liniger, M., Neuhaus, C., Hofmann, T., Fransioli-Ignazio, L., Jordi, M., Drueckes, P., Trappe, J., Fabbro, D., Altmann, K.-H. ACSMed. Chem. Lett., 2011, 2, 22-27.
A ring-closing metathesis (RCM)-based approach to mycolactones A/B. Gersbach P.; Jantsch A.; Feyen F.; Scherr N.; Dangy J.-P.; Pluschke G.; Altmann K.-H. Chemistry, 2011, 17(46), 13017-31.
The Binding Mode of Side Chain- and C3-Modified Epothilones to Tubulin. Erdelyi, M., Navarro-Vazquez, A., Pfeiffer, B., Kuzniewski, C. N., Felser, A., Widmer, T., Gertsch, J., Pera, B., Diaz, J. F., Altmann, K.-H., T. Carlomagno, T., ChemMedChem, 2010, 5, 911-920.
Identification of serotonin 5-HT1A receptor partial agonists in ginger. Nievergelt, A., Huonker, P., Schoop, R., Altmann, K.-H. Bioorg. Med. Chem., 2010, 18, 3345-3351.
Highly Potent Modulation of GABAA Receptors by Valerenic Acid Derivatives. Kopp, S., Baur, R., Sigel, E., Moehler, H., Altmann, K.-H. ChemMedChem, 2010, 5, 678-681.
Synthesis of (-)-Dactylolide and 13-Desmethylene-(-)-dactylolide and Their Effects on Tubulin. Zurwerra, D., Gertsch, J., Altmann, K.-H. Org. Lett., 2010, 12, 2302-2305.