杨哲 - 西安交通大学 - 生命科学与技术学院

个人简介

2006.9~2010.7 西北大学化学与材料科学学院理学学士 2010.9~2015.6 中山大学生物医学工程学院工学博士 2015.7~2019.1 西安交通大学生命科学与技术学院讲师 2017.10~2018.10 美国加州大学圣地亚哥分校（UCSD) Institute of Genomic Medicine 访问学者 2019.2~至今西安交通大学生命科学与技术学院副教授

研究领域

新型生物可降解材料的设计与合成靶向纳米药物、基因载体的制备及其抗肿瘤研究有机-无机复合型纳米粒子针对肿瘤热疗与化疗的联合治疗研究靶向纳米技术针对盐敏感高血压的诊疗研究

近期论文

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Yang Z., Sun N., Cheng R., Zhao C. Y., Liu Z., Li X., Liu J. and Tian Z. M. pH multistage responsive micellar system with charge-switch and PEG layer detachment for co-delivery of paclitaxel and curcumin to synergistically eliminate breast cancer stem cells (2017). Biomaterials, 147: 53-67. IF: 8.806 Yang Z., Cheng R., Zhao C., Sun N., Luo H., Chen Y., Liu Z., Li X., Liu J., Tian Z. M. Thermo-and pH-dual responsive polymeric micelles with upper critical solution temperature behavior for photoacoustic imaging-guided synergistic chemo-photothermal therapy against subcutaneous and metastatic breast tumors (2018). Theranostics, 8: 4097-4115. IF:8.537 Yang Z., Luo H., Cao Z., Chen Y., Gao J., Li Y., Jiang Q., Xu R. and Liu J. Dual-targeting hybrid nanoparticles for the delivery of SN38 to Her2 and CD44 overexpressed human gastric cancer (2016). Nanoscale, 8: 11543–11558. IF: 7.760 Yang Z., Jiang Z.Z., Cao Z., Zhang C., Gao D., Luo X.G., Zhang X.F., Luo H.Y., Jiang Q. and Liu J. Multifunctional non-viral gene vectors with enhanced stability, improved cellular and nuclear uptake capability, and increased transfection efficiency (2014). Nanoscale, 6:10193-10206. IF: 7.367 Yang Z., Tang W.X., Luo X.G., Zhang X.F., Zhang C., Li H., Gao D., Luo H.Y., Jiang Q. and Liu J. Dual-Ligand Modified Polymer-Lipid Hybrid Nanoparticles for Docetaxel Targeting Delivery to Her2/neu Overexpressed Human Breast Cancer Cells (2015). Journal of Biomedical Nanotechnology, 11:1401-1417. IF: 7.578 Yang Z., Zhang X.F., Luo X.G., Jiang Q., Liu J., and Jiang Z.Z. Enzymatic Synthesis of Poly(butylene-co-sebacate-co-glycolate) Copolyesters and Evaluation of the Copolymer Nanoparticles as Biodegradable Carriers for Doxorubicin Delivery (2013). Macromolecules, 46:1743-1753. IF: 5.927 Yang Z., Sun N., Cheng R., Zhao C. Y., Liu J. and Tian Z. M. Hybrid nanoparticles coated with hyaluronic acid lipoid for targeted co-delivery of paclitaxel and curcumin to synergistically eliminate breast cancer stem cells (2017). Journal of Materials Chemistry B, 5: 6762-6775. IF:4.776 Sun N., Zhao C., Cheng R., Liu Z., Li X., Lu A., Tian Z. M.*, Yang Z.*(Correspondence author) Cargo-free nano-medicine with pH-sensitivity for co-delivery of DOX conjugated prodrug with SN38 to synergistically eradicate breast cancer stem cells (2018). Molecular Pharmaceutics, DOI: 10.1021/acs.molpharmaceut.8b00367 IF:4.556 Yang Z., Gao D., Cao Z., Zhang C., Cheng D., Liu J. and Shuai X.T. Drug and gene co-delivery systems for cancer treatment (2015). Biomaterials Science, 3:1035-1049. IF:4.210 Yang Z.，Li Y.Q.，Gao J.B.，Cao Z.，Jiang Q. and Liu J.，pH and redox dual-responsive multifunctional gene delivery with enhanced capability of transporting DNA into the nucleus (2017)，Colloids and Surfaces B: Biointerfaces，153:111-122. IF: 3.887 Wang Y., Yang P.F., Zhao X. R., Gao D., Tian Z.M., Ma T. Y. and Yang Z.* (Correspondence author) Multifunctional Cargo-Free Nanomedicine for Cancer Therapy (2018). International Journal of Molecular Sciences, 19: E2963. IF:3.687 Zhao C., Cheng R., Yang Z.* (co-correspondence author), Tian Z. M.* Nanotechnology for Cancer Therapy Based on Chemotherapy (2018). Molecules, 23:826 IF:3.098 Zheng X.W., Li X.X., Chen M., Yang P.F., Zhao X.R., Zeng L., OuYang Y.N., Yang Z.* (co-correspondence author) and Tian Z.M.* The protective role of hawthorn fruit extract against high salt-induced hypertension in Dahl salt-sensitive rats: impact on oxidative stress and metabolic patterns (2019). Food & Function, 2019,10, 849-858. IF:3.289 Yang Z., Luo X.G., Zhang X.F., Liu J. and Jiang Q. Targeted delivery of 10-hydroxycamptothecin to human breast cancers by cyclic RGD-modiﬁed lipid–polymer hybrid nanoparticles (2013). Biomedical Materials, doi:10.1088/1748-6041/8/2/025012. IF:2.469 Luo H.Y.#, Yang Z.# (Co-first author), Wei W.#, Li Y.Q., Pu H.Y., Chen Y., Sheng H., Liu J. Xu R.H. Enzymatically synthesized poly(amino-co-ester) polyplexes for systemic delivery of pcDNA-miRNA-214 to suppress colorectal cancer liver metastasis (2018). Journal of Materials Chemistry B, 6, 6365-6376. IF:4.776