You, Lingchong - Duke University - Department of Biomedical Engineering

个人简介

The You lab uses a combination of mathematical modeling, machine learning, and quantitative experiments to elucidate principles underlying the dynamics of microbial communities in time and space and to control these dynamics for applications in computation, engineering, and medicine. EDUCATION Ph.D. University of Wisconsin - Madison, 2002 M.S. University of Science and Technology of China (China), 1997 B.S.E. Chengdu University of Science and Technology (China), 1994 AWARDS, HONORS, AND DISTINCTIONS Faculty Early Career Development (CAREER) Program. National Science Foundation. 2010 Fellowships for Science and Engineering. David and Lucile Packard Foundation. 2006

研究领域

Quantitative biology, synthetic biology, machine learning, antibiotic resistance, microbiome

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

C. Zhang, W. Song, H. R. Ma, X. Peng, D. J. Anderson, V. G. Fowler, J. T. Thaden, M. Xiao, and L. You. (2020) Temporal encoding of bacterial identity and traits in growth dynamics. PNAS M. M. Villa, R. J. Bloom, J. D. Silverman, H. K. Durand, S. Jiang, A. Wu, E. P. Dallow, S. Huang, L. You, and L. A. David. (2020) Interindividual variation in dietary carbohydrate metabolism by gut Bacteria revealed with droplet microfluidic culture. Msystems J. H. Bethke, A. Davidovich, L. Cheng, W. Song, A. J. Lopatkin, J. T. Thaden, V. G. Fowler Jr. M. Xiao, and L. You. (2020) Environmental and genetic determinants of plasmid mobility in pathogenic Escherichia coli. Science Advances K. Kim and L. You. (2020) Bacterial Aggregation Leads to Collective Elimination. Trends in Microbiology B. Mathey-Prevot, B.-T. Parker, C. Im, C. Hong, P. Dong, G. Yao, and L. You. (2020) Quantifying E2F1 protein dynamics in single cells. Quantitative Biology K. Zhu, S. Chen, T. Sysoeva, and L. You. (2019) Universal antibiotic tolerance arising from antibiotic-triggered accumulation of pyocyanin in Pseudomonas aeruginosa. PLoS Biology T. Sysoeva, Y. L. Kim, J. Rodriguez, A. J. Lopatkin, and L. You. (2019) Growth-stage dependent regulation of conjugation. AIChE Journal S. Wang, F. Kai, N. Luo, Y. Cao, F. Wu, C. Zhang, K. A. Heller, and. L. You. (2019) Massive computational acceleration by using neural networks to emulate mechanism-based biological models. Nature Communications W. Song, H. X. Sun, C. Zhang, L. Cheng, Y. Peng, Z. Deng, D. Wang, Y. Wang, M. Hu, W. Liu, H. Yang, Y. Shen, J. Li, L. You, and M. Xiao. (2019) Prophage Hunter: an integrative hunting tool for active prophages. Nucleic Acids Research X. Shi, L. You, and R. Luo. (2019) Glycolytic reprogramming in cancer cells: PKM2 dimer predominance induced by pulsatile PFK-1 activity. Physical Biology A.J. Lopatkin, J.M. Stokes, E.J. Zhang, J.H. Yang, M.K. Takahashi, L. You, and J.J. Collins. (2019) Bacterial metabolic state more accurately predicts antibiotic lethality than growth rate. Nature Microbiology Z. Dai, A.J. Lee, S. Roberts, T.A. Sysoeva, S. Huang, M. Dzuricky, X. Yang, X. Zhang, Z. Liu, A. Chilkoti, and L. You. (2019) Versatile biomanufacturing through stimulus-responsive cell-material feedback. Nature Chemical Biology J.R. Simon, S.A. Eghtesadi, M. Dzuricky, L. You, and A. Chilkoti. (2019) Engineered Ribonucleoprotein Granules Inhibit Translation in Protocells. Molecular Cell R. Tsoi, Z. Dai, and L. You. (2019) Emerging strategies for engineering microbial communities. Biotechnology Advances F. Wu, A.J. Lopatkin, D.A. Needs, C.T. Lee, S, Mukherjee, and L. You. (2019) A unifying framework for interpreting and predicting mutualistic systems. Nature Communications H.R. Meredith, V. Andreani, H.R. Ma, A.J. Lopatkin, A.J. Lee, D.J. Anderson, G. Batt, and L. You. (2018) Applying ecological resistance and resilience to dissect bacterial antibiotic responses. Science Advances Y. Feng, K.E. Marusak, L. You, and and S. Zauscher. (2018) Biosynthetic Transition Metal Chalcogenide Semiconductor Nanoparticles: Progress in Synthesis, Property Control and Applications. Current Opinion in Colloid & Interface Science A.J. Lee, S. Wang, H.R. Meredith, B. Zhang, Z. Dai, and L. You. (2018) Robust, linear correlations between growth rates and Β-lactam-mediated lysis rates. PNAS R. Tsoi, F. Wu, C. Zhang, S. Bewick, D. Karig, and L. You. (2018) Metabolic division of labor in microbial systems. PNAS K.E. Marusak, J.R. Krug, Y. Feng, Y. Cao, L. You, and S. Zauscher. (2018) Bacterially driven cadmium sulfide precipitation on porous membranes: Towards platforms for photocatalytic applications. Biointerphases P. Dong, C. Zhang, B.T. Parker, L. You, and B. Mathey-Prevot. (2018) Cyclin D/CDK4/6/ activity controls G1 length in mammalian cells. PLoS One