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个人简介

教育经历 2011.09 - 2016.06 华东师范大学 化学与分子工程学院 博士 (导师:周剑教授) 2007.09 - 2011.07 江西师范大学 化学化工学院 学士 (导师:丁秋平教授) 工作经历 2019.02 - 至今: 华东师范大学 化学与分子工程学院 青年研究员 (紫江青年学者) 2017.01 - 2019.01 日本微生物化学研究所 (JSPS博士后,导师:Masakatsu Shibasaki教授) 2016.07 - 2017.01 上海药明康德新药开发有限公司 (高级研究员) 荣誉及奖励 2017年 日本学术振兴会(JSPS)博后奖学金 2016年 上海市优秀毕业生 2015年 华东师范大学研究生校长奖学金(全校共6人) 2015年 博士研究生国家奖学金 2014年 华东师范大学优秀学生称号 2012年 硕士研究生国家奖学金 2012年 华东师范大学校长奖学金二等奖

研究领域

含氟、含硅有机化合物的高效高选择性构建及其应用研究;绿色农药创制研究

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

X.-X. Zhang, Y. Gao, Y.-X. Zhang, J. Zhou, J.-S. Yu,* Highly Enantioselective Construction of Multifunctional Silicon-Stereogenic Silacycles by Asymmetric Enamine Catalysis. Angew. Chem. Int. Ed. 2023, e202217724. B.-S. Mu, Y. Gao, F.-M. Yang, W.-B. Wu, Y. Zhang, X. Wang,* J.-S. Yu,* J. Zhou,* The Bifunctional Silyl Reagent Me2(CH2Cl)SiCF3 Enables Highly Enantioselective Ketone Trifluoromethylation and Related Tandem Processes. Angew. Chem. Int. Ed. 2022, e202208861. L. Liao, Y. Zhang, Z.-W. Wu, Z.-T. Ye. X.-X. Zhang, G. Chen, J.-S. Yu,* Nickel-catalyzed regio- and enantio-selective Markovnikov hydromonofluoroalkylation of 1,3-dienes. Chem. Sci. 2022, 13, 12519. C.-W. Lei, X.-Y. Wang, B.-S. Mu, J.-S. Yu*, Y. Zhou*, and J. Zhou*, Me2(CH2Cl)SiCF3 Facilitated Tandem Synthesis of Oxasilacycles Featuring a Trifluoromethyl Group. Org. Lett. 2022, 24, 8364–8369. W.-B. Wu, B.-S. Mu, J.-S. Yu*, J. Zhou, Me2(CH2=CH)SiCN: a bifunctional ethylene equivalent for Diels-Alder reaction based controllable tandem synthesis. Chem. Sci. 2022, 13, 3519-3525. X.-X. Zhang, Y. Zhang, L. Liao, Y. Gao, H. E. M. Su*, J.-S. Yu*, Catalytic Asymmetric Isomerization of (Homo)Allylic Alcohols: Recent Advances and Challenges. ChemCatChem 2022, 14, e202200126. B.-S. Mu, X.-Y. Cui, X.-P. Zeng, J.-S. Yu,* J. Zhou,* Modular synthesis of chiral 1,2-dihydropyridines via Mannich/Wittig/cycloisomerization sequence that internally reuses waste. Nat. Commun. 2021, 12, 2219. C.-W. Lei, B.-S. Mu, F. Zhou,* J.-S. Yu,* Y. Zhou,* J. Zhou, Organocatalytic enantioselective reactions involving prochiral carbocationic intermediates. Chem. Commun. 2021, 57, 9178-9191. J.-X. He, Y. Zhang, B.-S. Mu, X.-Y. Cui, J. Zhou, J.-S. Yu,* Catalyst-Free and Solvent-Controlled Divergent Synthesis of Difluoromethylene-Containing S-Heterocycles.J. Org. Chem. 2021, 86, 9206-9217. X.-S. Hu, J.-X. He, Y. Zhang, J. Zhou, J.-S. Yu,* Highly Stereoselective Positional Isomerization of Styrenes via Acid-Catalyzed Carbocation Mechanism. Chin. J. Chem. 2021, 39, 2227-2233. X.-X. Zhang, Y. Gao, X.-S. Hu, C.-B. Ji,* Y.-L. Liu, J.-S. Yu*, Recent Advances in Catalytic Enantioselective Synthesis of Fluorinated alpha- and beta-Amino Acids. Adv. Synth. Catal. 2020,362, 4763 (VIP, Cover picture). Q. Xiao, J.-S. Yu (co-first author), Y. Wang, D. Ma, J. Zhou*, and X. Lou*, 3-Difluoroalkyl Quaternary Oxindoles Inhibit Macrophage Pyroptosis by Blocking Inflammasome Recruitment of Caspase-1. ACS Med. Chem. Lett.2020, 11, 1392–1401. X.-S. Hu, J.-X. He, S.-Z. Dong, Q.-H. Zhao, J.-S. Yu*, J. Zhou*, Regioselective Markovnikov hydrodifluoroalkylation of mono-, di-, tri-, and tetrasubstituted alkenes using difluoroenoxysilanes. Nature Commun. 2020, 11, 5500. P.-G. Ding, X.-S. Hu, J.-S. Yu*, J. Zhou*, Diastereodivergent Synthesis of α-Chiral Tertiary Azides through Catalytic Asymmetric Michael Addition. Org. Lett. 2020, DOI: 10.1021/acs.orglett.0c03123. B.-W. Pan, Y. Shi, Y.-P. Tian, J.-S. Yu*, Y. Zhou*, J. Zhou*, Synthesis of Multifunctional α,α-Difluoroketones through Allylic Alkylation of Difluoroenoxysilanes with MBH Carbonates. Chem. Asian J. 2020, DOI: 10.1002/asia.202001145. Y. Shi, B.-W. Pan, J.-S. Yu*, Y. Zhou,* J. Zhou*, Recent Advances in Applying Carbonyl-stabilized Phosphorus Ylides for Catalysis. ChemCatChem 2020, DOI: 10.1002/cctc.202001371. Y.-J. Hao, Y. Gong, Y. Zhou,* J. Zhou, J.-S. Yu*, Construction of beta-Quaternary α,α-Difluoroketones via Catalytic Nucleophilic Substitution of Tertiary Alcohols with Difluoroenoxysilanes. Org. Lett. 2020, DOI: 10.1021/acs.orglett.0c03123. W.-B. Wu, J.-S. Yu*, J. Zhou* Catalytic Enantioselective Cyanation: Recent Advances and Perspectives. ACS Catal. 2020, 10, 7668. Y.-J. Hao, X.-S. Hu, Y. Zhou*, J. Zhou, J.-S. Yu*, Catalytic Enantioselective α-Arylation of Carbonyl Enolates and Related Compounds. ACS Catal. 2020, 10, 955-993. X.-S. Hu, J.-S. Yu*, J. Zhou*, Catalytic selective mono- and difluoroalkylation using fluorinated silyl enol ethers. Chem. Commun. 2019, 55, 13638-13648. X.-S. Hu, P.-G. Ding, J.-S. Yu*, J. Zhou*, A Sc(OTf)3 catalyzed Mukaiyama-Mannich reaction of difluoroenoxysilanes with unactivated ketimines. Org. Chem. Front. 2019, 6, 2500-2505. Y.-P. Tian, Y. Gong, Hu, X.-S. Hu, J.-S. Yu*, Y. Zhou*, J. Zhou*, HClO4 catalysed aldol-type reaction of fluorinated silyl enol ethers with acetals or ketals toward fluoroalkyl ethers. Org. Biomol. Chem. 2019, 17, 9430-9434. K. Liao, X.-S. Hu, R.-Y. Zhu, R.‐H. Rao, J.-S. Yu*, F. Zhou, J. Zhou*, Catalytic Enantioselective Protonation of Monofluorinated Silyl Enol Ethers towards Chiral α-Fluoroketones. Chin. J. Chem.2019, 37, 799-806. (封面文章) P.-W. Xu, J.-S. Yu*, C. Chen, Z.-Y. Cao, F. Zhou, J. Zhou*, Catalytic Enantioselective Construction of Spiro Quaternary Carbon Stereocenters. ACS Catal.2019, 9, 1820-1882. Y. Gong, J.-S. Yu*, Y.-J. Hao, Y. Zhou*, J. Zhou*, Catalytic Enantioselective Aldol-Type Reaction Using alpha-Fluorinated Enolates. Asian J. Org. Chem.2019, 8, 610-626. J.-S. Yu, M. Espinosa, H. Noda*, M. Shibasaki*, Traceless Electrophilic Amination for the Synthesis of Unprotected Cyclic β?Amino Acids. J. Am. Chem. Soc. 2019, 141, 10530-10537. (Highlighted by Synfacts2019, 1072) J.-S. Yu, H. Noda, N. Kumagai*, M. Shibasaki*, Direct Catalytic Asymmetric Mannich-Type Reaction of an α-CF3 Amide to Isatin Imines. Synlett, 2019, 30, 488-492. (Invited paper as part of the 30 Years SYNLETT-Pearl Anniversary Issue) J.-S. Yu, H. Noda*, M. Shibasaki*, Quaternary β2,2-Amino Acids: Catalytic Asymmetric Synthesis and Incorporation into Peptides by Fmoc-Based Solid-Phase Peptide Synthesis. Angew. Chem. Int. Ed. 2018, 57, 818-822. J.-S. Yu, H. Noda*, M. Shibasaki*, Exploiting β-Amino Acid Enolates in Direct Catalytic Diastereo- and Enantioselective C-C Bond-Forming Reactions. Chem. Eur. J.2018, 24, 15796-15800. J.-S. Yu, H.-M. Huang, P.-G. Ding, X.-S. Hu, F. Zhou, J. Zhou*, Catalytic Enantioselective Construction of Sulfur-containing Tetrasubstituted Carbon Stereocenters. ACS Catal. 2016, 6, 5139-5344. J.-S. Yu, J. Zhou*, Organocatalytic Enantioselective Mukaiyama–Mannich Reaction of Fluorinated Enol Silyl Ethers and Cyclic N-Sulfonyl Ketimines. Org. Chem. Front. 2016, 3, 298-303. J.-S. Yu, W.-B. Wu, F. Zhou*, The First Catalytic Asymmetric Thioacetalization by Chiral Phosphoric Acid Catalysis. Org. Biomol. Chem.2016, 14, 2205-2209. J.-S. Yu, F.-M. Liao, W.-M. Gao, K. Liao, J. Zhou*, Michael Addition Catalyzed by Chiral Secondary Amine Phosphoramide Using Fluorinated Silyl Enol Ethers: Formation of Quaternary Carbon Stereocenters. Angew. Chem. Int. Ed. 2015, 54, 7381-7385. (Highlighted by Synfacts 2015, 876) J.-S. Yu, J. Zhou*, A Highly Efficient Mukaiyama–Mannich Reaction of N-Boc Isatin Ketimines and Other Active Cyclic Ketimines Using Difluoro Enol Silyl Ethers Catalyzed by Ph3PAuOTf. Org. Biomol. Chem. 2015, 13, 10968-10972. (封面文章) J.-S. Yu, Y.-L. Liu, J. Tang, X. Wang*, J. Zhou*, Highly Efficient“On Water” Catalyst-free Nucleophilic Addition Reactions Using Difluoroenoxysilanes: Dramatic Fluorine Effects. Angew. Chem. Int. Ed. 2014?53, 9512-9516. (被《有机化学》(2014, 34, 2184)作为亮点工作介绍)

学术兼职

Associate Editor of the Organocatalysis section in Frontiers in Catalysis. (2021.07- ) Editorial Board Member of Current Organocatalysis. (2020.11- )

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