Zhu, Jieping - École polytechnique fédérale de Lausanne EPFL - Institute of Chemical Sciences and Engineering

个人简介

Education 1984, B.Sc., Hanzhou Normal University, P. R. China 1987, M.Sc., Lanzhou University (Prof. Y.-L. Li), P. R. China 1991, Ph.D., Université Paris XI (Prof. H.-P. Husson and Prof. J.-C. Quirion), France 1991-1992, Post-doct., Texas A & M University (Prof. Sir D. H. R. Barton), USA Academic Positions 1992-2000, “Chargé de Recherche” at ICSN, CNRS, France 2000-2006, Director of Research, 2nd class, at ICSN CNRS, France 2006-2010, Director of Research, 1st class at ICSN, CNRS, France 2010-present, Professor, ISIC, EPFL Awards 1996, CNRS bronze medal (1996) 1999, French Chemical Society SCF-Acros award (1999) 2002, AstraZeneca Award in Organic Chemistry (UK) 2002, Japan Society for Promotion of Science (JSPS) fellow 2003, Prix Emile Jungfleisch of French Academy of Sciences 2003, National Science Foundation Outstanding Young Oversea Scientist award (China) 2004, Liebig Lectureship of the German Chemical Society 2008, Novartis Chemistry Lecture Award (Switzerland) 2009, CNRS Silver medal 2010, French Chemical Society-Division of Organic Chemistry SCF-DCO award. 2015, Nankai University Lectureship on Organic Chemistry, Nankai University, Tianjing, P. R: China 2016, Royal Society of Chemistry (RSC) Natural Product Chemistry Award, UK 2017, KAIST-BK21 School of Molecular Science Lectureship award, South Korea

研究领域

The interest of the Zhu group is mainly focused on the total synthesis of natural complex molecules, development of novel efficient synthetic methods and catalytic enantioselective transformations. Total synthesis of natural product Multicomponent reactions Metal-catalyzed domino process Catalytic enantioselective transformations

近期论文

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Arylative Ring Expansion of 3-Vinylazetidin-3-Ols and 3-Vinyloxetan-3-Ols to Dihydrofurans by Dual Palladium and Acid Catalysis T. Fujii; Q. Wang; J. Zhu Angewandte Chemie-International Edition 2024-04-12 DOI : 10.1002/anie.202403484 Editing Tetrasubstituted Carbon: Dual C–O Bond Functionalization of Tertiary Alcohols Enabled by Palladium-Based Dyotropic Rearrangement T. C. P. Delcaillau; B. Yang; Q. Wang; J. Zhu Journal of the American Chemical Society 2024 Vol. 146 , num. 16, p. 11061-11066. DOI : 10.1021/jacs.4c02924 Catalytic Enantioselective Synthesis of Inherently Chiral Macrocycles by Dynamic Kinetic Resolution Q-L. Lu; X-D. Wang; S. Tong; J. Zhu; M-X. Wang ACS Catalysis 2024 Vol. 14 , num. 7, p. 5140-5146. DOI : 10.1021/acscatal.4c00598 Benzylic C(sp3)-H Azidation: Copper vs Iron Catalysis A. Renteria-Gomez; R. O. Torres-Ochoa; P. Palamini; R. Simonet-Davin; Q. Wang et al. Helvetica Chimica Acta 2024-03-04 DOI : 10.1002/hlca.202400004 Chalcogen bonding catalysis G. Sekar; V. V. Nair; J. Zhu Chemical Society Reviews 2024 Vol. 53 , num. 2, p. 586-605. DOI : 10.1039/D3CS00503H Palladium‐Based Dyotropic Rearrangement Enables A Triple Functionalization of Gem‐Disubstituted Alkenes: An Unusual Fluorolactonization Reaction Q. Feng; C. Liu; Q. Wang; J. Zhu Angewandte Chemie International Edition 2024 Vol. 63 , num. 1, p. e202316393. DOI : 10.1002/anie.202316393 Enantioselective Total Synthesis of (-)-Artatrovirenol A R. Lavernhe; P. Domke; Q. Wang; J. Zhu Journal Of The American Chemical Society 2023-10-24 Vol. 145 , num. 44, p. 24408-24415. DOI : 10.1021/jacs.3c09683 Synthesis and Applications of Ynimines and Enantioselective Total Synthesis of Artatrovirenol A R. H. Lavernhe / Director(s) : J. Zhu Lausanne: EPFL 2023 p. 446. DOI : 10.5075/epfl-thesis-10563 Diverting the 5-exo-Trig Oxypalladation to Formally 6-endo-Trig Fluorocycloetherification Product through 1,2-O/Pd(IV) Dyotropic Rearrangement J. Gong; Q. Wang; J. Zhu Journal of the American Chemical Society 2023 Vol. 145 , num. 29, p. 15735-15741. DOI : 10.1021/jacs.3c06158 Asymmetric Synthesis of Enantioenriched Zigzag-Type Molecular Belts by Kinetic Resolution and Subsequent Transformations Y-Q. Mao; Y. Zhang; S. Tong; J. Zhu; M-X. Wang Organic Letters 2023 Vol. 25 , num. 21, p. 3936-3940. DOI : 10.1021/acs.orglett.3c01314 Dual Photoredox and Copper Catalysis: Enantioselective 1,2-Amidocyanation of 1,3-Dienes D. Forster; W. Guo; Q. Wang; J. Zhu ACS Catalysis 2023 Vol. 13 , num. 11, p. 7523-7528. DOI : 10.1021/acscatal.3c01782 Terminal Alkynes as One-Carbon Donors in [5+1] Heteroannulation: Synthesis of Pyridines via Ynimine Intermediates and Application in the Total Synthesis of Anibamine B R. Lavernhe; Q. Wang; J. Zhu Angewandte Chemie-International Edition 2023-04-21 DOI : 10.1002/anie.202303537 TiCl3-Mediated Reductive Cyclization of Tetrasubstituted Alkenes and Enol Esters Bearing a 2-Nitrophenyl Substituent D. Boyarskaya / Director(s) : J. Zhu Lausanne: EPFL 2023 p. 351. DOI : 10.5075/epfl-thesis-10074 Asymmetric Construction of α,α‐Disubstituted Piperazinones Enabled by Benzilic Amide Rearrangement Y. He; R. Quan; X. Li; J. Zhu; H. Wu Angewandte Chemie International Edition 2023-04-24 Vol. 62 , num. 18. DOI : 10.1002/anie.202217954 Terminal Alkynes as One-Carbon Donors in [5+1] Heteroannulation: Synthesis of Pyridines via Ynimine Intermediates and Application in the Total Synthesis of Anibamine B R. Lavernhe; Q. Wang; J. Zhu Angewandte Chemie-International Edition 2023-04-21 DOI : 10.1002/anie.202303537 Divergent Asymmetric Total Synthesis of (−)‐Voacafricines A and B R. Andres; Q. Wang; J. Zhu Angewandte Chemie International Edition 2023-04-11 Vol. 62 , num. 16, p. e202301517. DOI : 10.1002/anie.202301517 Highly Strained Oxygen‐Doped Chiral Molecular Belts of the Zigzag‐Type with Strong Circularly Polarized Luminescence J. Chen; Z. Jiang; H. Xiao; S. Tong; T. Shi et al. Angewandte Chemie International Edition 2023-04-03 Vol. 62 , num. 15, p. e202301782. DOI : 10.1002/anie.202301782 Oxidative rearrangement of 1,1-disubstituted alkenes to ketones Q. Feng; Q. Wang; J. Zhu 2023-03-30 Vol. 379 , num. 6639, p. 1363-1368. DOI : 10.1126/science.adg3182 Enantioselective Total Synthesis of (+)-Stephadiamine B. Yang; G. Li; Q. Wang; J. Zhu Journal of the American Chemical Society 2023-02-27 Vol. 145 , num. 9, p. 5001-5006. DOI : 10.1021/jacs.3c00884 Inherently chiral calixarenes by a catalytic enantioselective desymmetrizing cross-dehydrogenative coupling X. Zhang; S. Tong; J. Zhu; M-X. Wang Chemical Science 2023-01-28 Vol. 14 , num. 4, p. 827-832.DOI : 10.1039/D2SC06234H Organocatalytic Enantioselective Pictet–Spengler Reaction of α‐Ketoesters: Development and Application to the Total Synthesis of (+)‐Alstratine A R. Andres; F. Sun; Q. Wang; J. Zhu Angewandte Chemie International Edition 2023-01-02 Vol. 62 , num. 1, p. e202213831 .DOI : 10.1002/anie.202213831 Organocatalytic Enantioselective Diels-Alder Reaction of 2-Trifluoroacetamido-1,3-dienes with alpha,beta-Unsaturated Ketones X-Q. Zhu; Q. Wang; J. Zhu Angewandte Chemie-International Edition 2022-11-29 DOI : 10.1002/anie.202214925 Apparent 6-endo-trig Carbofluorination of Alkenes Enabled by Palladium-Based Dyotropic Rearrangement J. Gong; Q. Wang; J. Zhu Angewandte Chemie-International Edition 2022-11-16 DOI : 10.1002/anie.202211470 Synthesis of 3-Acyloxyindolenines by TiCl3-Mediated Reductive Cyclization of 2-(ortho-Nitroaryl)-Substituted Enol Esters D. V. Boyarskaya; A. Ongaro; C. Piemontesi; Q. Wang; J. Zhu DOI : 10.1021/acs.orglett.2c02860 Thiazole Boron Difluoride Dyes with Large Stokes Shift, Solid State Emission and Room-Temperature Phosphorescence W. Wang; S. Tong; Q-Q. Wang; Y-F. Ao; D-X. Wang et al. DOI : 10.1002/chem.202202507 Migrative Carbofluorination of Saturated Amides Enabled by Pd-Based Dyotropic Rearrangement G. Yang; H. Wu; S. Gallarati; C. Corminboeuf; Q. Wang et al. Journal of the American Chemical Society 2022-08-02 Vol. 144 , num. 31, p. 14047-14052. DOI : 10.1021/jacs.2c06578 Two-Carbon Ring Expansion of Cyclobutanols to Cyclohexenones Enabled by Indole Radical Cation Intermediate: Development and Application to a Total Synthesis of Uleine A. Leclair; Q. Wang; J. Zhu Acs Catalysis 2022-01-05 Vol. 12 , num. 2, p. 1209–1215. DOI : 10.1021/acscatal.1c05621 Taming the radical cation intermediate enabled one-step access to structurally diverse lignans J-C. Xiang; C. Fung; Q. Wang; J. Zhu Nature Communications 2022 Vol. 13 , num. 1, p. 13:3481. DOI : 10.1038/s41467-022-31000-4 Catalytic Enantioselective Pictet–Spengler Reaction of α‐Ketoamides Catalyzed by a Single H‐Bond Donor Organocatalyst R. Andres; Q. Wang; J. Zhu Angewandte Chemie International Edition 2022 Vol. 61 , num. 19, p. e202201788. DOI : 10.1002/anie.202201788 Modular Synthesis of Benzocyclobutenes via Pd(II)-Catalyzed Oxidative [2+2] Annulation of Arylboronic Acids with Alkenes T. Fujii; S. Gallarati; C. Corminboeuf; Q. Wang; J. Zhu Journal of the American Chemical Society 2022 DOI : 10.1021/jacs.2c03565 Asymmetric Total Synthesis of Indole Alkaloids (+)-Condyfoline, (-)-Tubifoline, (+)-Dasycarpidone and (+)-Uleine B. Delayre / Director(s) : J. Zhu Lausanne: EPFL 2022 p. 244. DOI : 10.5075/epfl-thesis-9160 Photoredox Catalytic Three-Component Amidoazidation of 1,3-Dienes D. Forster; W. Guo; Q. Wang; J. Zhu Acs Catalysis 2021-09-03 Vol. 11 , num. 17, p. 10871-10877. DOI : 10.1021/acscatal.1c03545 Copper‐Catalyzed Aza‐Sonogashira Cross‐Coupling to Ynimines: Development and Application to the Synthesis of Heterocycles R. Lavernhe; R. O. Torres-Ochoa; Q. Wang; J. Zhu Angewandte Chemie International Edition 2021-09-01 Vol. 60 , num. 45, p. 24028-24033. DOI : 10.1002/anie.202110901 Enantioselective Total Synthesis of (+)-Nordasycarpidone, (+)-Dasycarpidone, and (+)-Uleine B. Delayre; C. Fung; Q. Wang; J. Zhu Helvetica Chimica Acta 2021-07-06 Vol. 104 , num. 8, p. e2100088. DOI : 10.1002/hlca.202100088 C-C bond activation enabled by dyotropic rearrangement of Pd(iv) species J. Cao; H. Wu; Q. Wang; J. Zhu Nature Chemistry 2021-05-24 Vol. 13 , p. 671–676. DOI : 10.1038/s41557-021-00698-y Visible light photoredox-catalysed remote C-H functionalisation enabled by 1,5-hydrogen atom transfer (1,5-HAT) W. Guo; Q. Wang; J. Zhu Chemical Society Reviews 2021-05-20 Vol. 50 , num. 13, p. 7359-7377. DOI : 10.1039/d0cs00774a Enantioselective Total Synthesis of (+)-Alstilobanine C, (+)-Undulifoline, and (-)-Alpneumine H G. Li; N. Gaeng; C. Piemontesi; Q. Wang; J. Zhu Angewandte Chemie-International Edition 2021-04-23 Vol. 60 , num. 12, p. 12392-12395. DOI : 10.1002/anie.202103580