Waser, Jérôme - École polytechnique fédérale de Lausanne EPFL - Institute of Chemical Sciences and Engineering

个人简介

Jérôme Waser was born in Sierre, Valais, Switzerland in October 1977. From 1997 to 2001, he studied chemistry at the ETH Zurich. After a summer internship at Lonza AG in Visp in 2000, he chose organic chemistry as specialization and obtained his Diploma under the supervision of Prof. Erick M. Carreira and Dr. Christian Fischer in 2001. In 2002, he started his Ph.D. studies at the ETH Zurich also under the supervision of Prof. Erick M. Carreira. During his Ph.D., he worked on the development of new metal-catalyzed amination reactions, which culminated in a new access to azides and hydrazines directly from olefins. After obtaining his PhD in 2006, he then joined the group of Prof. Barry M. Trost at Stanford University as a postdoctoral fellow. While at Stanford, he worked on the total synthesis of Pseudolaric Acid B, a diterpene natural product displaying interesting antifungal, antifertility and antitumor activity. His principal focus of research is the development and application of new catalytic methods for the synthesis of bioactive compounds.

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Platinum-Catalyzed Domino Reaction with Benziodoxole Reagents for Accessing Benzene-Alkynylated Indoles Yifan Li and Jerome Waser Angew. Chem., Int. Ed. 2015, 54, ASAP. (DOI: 10.1002/anie.201412321) Palladium-Catalyzed Vicinal Amino Alcohols Synthesis from Allyl Amines by in Situ Tether Formation and Carboetherification Ugo Orcel and Jerome Waser Angew. Chem., Int. Ed. 2015, 54, ASAP. (DOI: 10.1002/anie.201500636) [4+2]-Annulations of Aminocyclobutanes Daniele Perrotta, Sophie Racine, Jeremy Vuilleumier, Florian de Nanteuil and Jerome Waser Org. Lett. 2015, 17, 1030-1033. (DOI: 10.1021/acs.orglett.5b00149) One-Pot, Three-Component Arylalkynyl Sulfone Synthesis C. Chun Chen and Jerome Waser Org. Lett. 2015, 17, 736-739. (DOI: 10.1021/acs.orglett.5b00015) General and Practical Formation of Thiocyanates from Thiols Reto Frei, Thibaut Courant, Matthew D. Wodrich and Jerome Waser Chem. Eur. J. 2015, 21, 2662-2668. (DOI: 10.1002/chem.201406171) Fast and Highly Chemoselective Alkynylation of Thiols with Hypervalent Iodine Reagents Enabled through a Low Energy Barrier Concerted Mechanism Reto Frei, Matthew D. Wodrich, Durga Prasad Hari, Pierre-Antoine Borin, Clement Chauvier and Jerome Waser J. Am. Chem. Soc. 2014, 136, 16563-16573. (DOI: 10.1021/ja5083014) Enantioselective Synthesis of Polycyclic Carbocycles via an Alkynylation–Allylation–Cyclization Strategy Maria Victoria Vita, Pacal Mieville and Jerome Waser Org. Lett. 2014, 16, 5768-5771. (DOI: 10.1021/ol5028333) Room temperature alkynylation of H-phosphi(na)tes and secondary phosphine oxides with ethynylbenziodoxolone (EBX) reagents C. Chun Chen and Jerome Waser Chem. Commun. 2014, 50, 12923-12926. (DOI: 10.1039/C4CC06851C ) Diester-Substituted Aminocyclopropanes: Synthesis and Use in [3+2]-Annulation Reactions Eloisa Serrano, Florian de Nanteuil and Jerome Waser Synlett 2014, 25, 2285-2288. (DOI: 10.1055/s-0034-1378512) Synthesis of (Carbo)nucleoside Analogues by [3+2] Annulation of Aminocyclopropanes Sophie Racine, Florian de Nanteuil, Eloisa Serrano and Jerome Waser Angew. Chem., Int. Ed. 2014, 53, 8484-8487. (DOI: 10.1002/anie.201404832) Dynamic Kinetic Asymmetric [3 + 2] Annulation Reactions of Aminocyclopropanes Florian de Nanteuil, Eloisa Serrano, Daniele Perrotta and Jerome Waser J. Am. Chem. Soc. 2014, 136, 6239-6242. (DOI: 10.1021/ja5024578) Total Synthesis and Biological Evaluation of Jerantinine E Reto Frei, Davide Staedler, Aruna Raja, Raimo Franke, Florenz Sasse, Sandrine Gerber-Lemaire and Jerome Waser Angew. Chem., Int. Ed. 2013, 52, 13373-13376. (DOI: 10.1002/anie.201305533) Zinc–gold cooperative catalysis for the direct alkynylation of benzofurans Yifan Li and Jerome Waser Beilstein J. Org. Chem. 2013, 9, 1763-1767. (DOI: 10.3762/bjoc.9.204) Synthesis of Aminocyclobutanes by Iron-Catalyzed [2+2] Cycloaddition Florian de Nanteuil and Jerome Waser Angew. Chem., Int. Ed. 2013, 52, 9009–9013. (DOI: 10.1002/anie.201303803) Catalytic Friedel–Crafts Reaction of Aminocyclopropanes Florian de Nanteuil, Joachim Loup and Jerome Waser Org. Lett. 2013, 15, 3738-3741. (DOI: 10.1021/ol401616a) A Highly Chemoselective and Practical Alkynylation of Thiols Reto Frei and Jerome Waser J. Am. Chem. Soc. 2013, 135, 9620-9623. (DOI: 10.1021/ja4044196) Azidation of Beta-Keto Esters and Silyl Enol Ethers with a Benziodoxole Reagent Maria Victoria Vita and Jerome Waser Org. Lett. 2013, 15, 3246-3249. (DOI: 10.1021/ol401229v) Ethynylbenziodoxolones (EBX) as Reagents for the Ethynylation of Stabilized Enolates Davinia Fernández González, Jonathan P. Brand, Régis Mondière and Jerome Waser Adv. Synth. Catal. 2013, 355, 1631-1639. (DOI: 10.1002/adsc.201300266) Gold-Catalyzed Regioselective Synthesis of 2- and 3-Alkynyl Furans Yifan Li, Jonathan P. Brand and Jerome Waser Angew. Chem., Int. Ed. 2013, 52, 6743-6747. (DOI: 10.1002/anie.201302210) Pd(0)-Catalyzed Alkene Oxy- and Aminoalkynylation with Aliphatic Bromoacetylenes Stefano Nicolai, Raha Sedigh-Zadeh , and Jerome Waser J. Org. Chem. 2013, 78, 3783-3801. (DOI: 10.1021/jo400254q)