Wandrey, Christine - École polytechnique fédérale de Lausanne EPFL - Institute of Chemical Sciences and Engineering

个人简介

Study of Chemistry at the Martin Luther University of Halle-Wittenberg, Germany - Doctoral studies at the Institute of Polymer Chemistry of the Academy of Sciences, Teltow, Germany, Dr. rer. nat. - Habilitation for Physical Chemistry at the Max Planck Institute of Colloids and Interfaces, Teltow, Germany, and at the University of Potsdam, Germany; Dr. rer. nat. habil.: 1997; Thesis: “Polyelectrolytes - Macromolecular parameters and electrolyte behavior” ISBN 3-89588-814-1 since 1996 at the EPFL, Private Docent since 1999 1996-2002 Laboratory of Polyelectrolytes and BioMacromolecules (LPBM), 2002-2004 Laboratory of Chemical Biotechnology (LBCH) 2004 Laboratory of Regenerative Medicine and Pharmacobiology (LMRP2)

研究领域

Polyelectrolytes, charged macromolecules, and their organized structures - belong to an emerging class of materials and are one of the key topics, internationally, in polymer chemistry and physics. - include synthetic compounds but also biopolymers, such as proteins, nucleic acids, or polysaccharides. - play a central role in the life sciences and have increasing importance as specialty polymers in many fields including environmental technologies, biotechnology, and materials development. Function and application primarily rely on electrostatic interactions with either low molar mass counterions, charged surfaces, or oppositely charged molecules. The aim of our research is to study polyelectrolyte interactions as a function of the macromolecular parameters, on one hand, and medium conditions and characteristics of the interacting partner, on the other hand. The research includes the synthesis of defined molecule architectures, their characterization, fundamental interaction studies, and the development of novel materials for various applications, preferably in the biomedical. Of specific interest are hydrogels and hydrocolloids for tissue engineering, immobilization, and delivery systems with micro and nano dimensions.

近期论文

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N. Zavradashvili, T. Memanishvili, N. Kupatadze, L. Baldi and X. Shen et al. Cell Compatible Arginine Containing Cationic Polymer: One-Pot Synthesis and Preliminary Biological Assessment. 1st International Conference on Infectious Diseases and Nanomedicine (ICIDN), Advances in Experimental Medicine and Biology 807, 2014. E. Montanari, R. Meier, R. Mahou, D. Bosco and F. Borcard et al. Alginate-PEG Biomaterial for Cell Microencapsulation and Xenotransplantation.World Transplant Congress, San Francisco, CA, 2014. E. Montanari, R. Meier, R. Mahou, D. Bosco and F. Borcard et al. Alginate-PEG Biomaterial for Cell Microencapsulation and Xenotransplantation.World Transplant Congress, San Francisco, CA, 2014. S. M. F. M. Passemard, S. Gerber and L. Juillerat-Jeanneret (Dirs.). Functionalization of Nanoparticles for Targeted Cancer Imaging and Diagnosis. EPFL, Lausanne, 2014. T. Memanishvili, N. Zavradashvili, N. Kupatadze, D. Tugushi and M. Gverdtsiteli et al. Arginine-Based Biodegradable Ether–Ester Polymers with Low Cytotoxicity as Potential Gene Carriers, in Biomacromolecules, p. 140711090449007, 2014. R. Mahou, R. P. H. Meier, L. H. Buehler and C. Wandrey. Alginate-Poly(ethylene glycol) Hybrid Microspheres for Primary Cell Microencapsulation, in Materials, vol. 7, num. 1, p. 275-286, 2014. E. Montanari, R. P. Meier, R. Mahou, D. Bosco and F. Borcard et al. Alginate-PEG biomaterial for cell microencapsulation and xenotransplantation. 101st Annual Congress of the Swiss-Society-of-Surgery, Berne, SWITZERLAND, 2014. R. P. H. Meier, J. D. Seebach, P. Morel, R. Mahou and S. Borot et al. Survival of Free and Encapsulated Human and Rat Islet Xenografts Transplanted into the Mouse Bone Marrow, in Plos One, vol. 9, num. 3, 2014. R. Meier, J. Seebach, P. Morel, R. Mahou and S. Borot et al. The Survival of Free and Encapsulated Islets Xenograft Transplanted in the Mouse Bone Marrow. 14th World Congress of the International-Pancreas-and-Islet-Transplant-Association (IPITA), 2013. U. Hasegawa, A. J. Van Der Vlies, C. Wandrey and J. A. Hubbell. Preparation of Well-Defined Ibuprofen Prodrug Micelles by RAFT Polymerization, in Biomacromolecules, vol. 14, num. 9, p. 3314-3320, 2013. H. Ahmadloo, C. Wandrey (Dir.). Synthesis and Properties of Highly-Charged Cationic Polyelectrolytes. EPFL, Lausanne, 2013. R. Meier, R. Mahou, P. Morel, Y. Muller and P. Christofilopoulos et al. Encapsulated mesenchymal stem cells xenotransplanted in mice produce anti-inflammatory cytokines and delay liver fibrosis. Joint Congress of 12th Congress of the International-Xenotransplantation-Association / iABO/Hyper Immune Symposium, 2013. E. Montanari, R. P. H. Meier, R. Mahou, F. Borcard and A. Bollinger et al. Alginate-PEG biomaterial for cell microencapsulation and xenotransplantation. Joint Congress of 12th Congress of the International-Xenotransplantation-Association / iABO/Hyper Immune Symposium, 2013. R. Meier, J. Seebach, P. Morel, R. Mahou and S. Borot et al. The survival of free and encapsulated islets xenograft transplanted in the mouse bone marrow. Joint Congress of 12th Congress of the International-Xenotransplantation-Association / iABO/Hyper Immune Symposium, 2013. M. Werner, K. Biss, V. Jerome, F. Hilbrig and R. Freitag et al. Use of the mitochondria toxicity assay for quantifying the viable cell density of microencapsulated jurkat cells, in Biotechnology Progress, vol. 29, num. 4, p. 986-993, 2013. R. Meier, R. Mahou, P. Morel, Y. Muller and P. Christofilopoulos et al. Encapsulated Human Mesenchymal Stem Cells Reduce Alpha-Smooth Muscle Actin and Increase Matrix Metalloproteinase-9 Expression during Liver Fibrosis.. 13th American Transplant Congress (ATC), 2013. S. E. Darwiche, D. Pioletti and L. A. Laurent-Applegate (Dirs.). Epiphyseal Chondro-Progenitor Cell Therapy For Articular Cartilage Regeneration. EPFL, Lausanne, 2013. G. G. Sahin Kurtuldu, H.-A. Klok (Dir.). Towards the Synthesis of Uniform Polymers by Template Polymerization. EPFL, Lausanne, 2013. A. Almalik, S. Karimi, S. Ouasti, R. Donno and C. Wandrey et al. Hyaluronic acid (HA) presentation as a tool to modulate and control the receptor-mediated uptake of HA-coated nanoparticles, in Biomaterials, vol. 34, num. 21, p. 5369-5380, 2013. A. S. Shaplov, D. O. Ponkratov, P. S. Vlasov, E. I. Lozinskaya and L. I. Komarova et al. Synthesis and properties of polymeric analogs of ionic liquids, in POLYMER SCIENCE SERIES B, vol. 55, num. 3-4, p. 122-138, 2013. I. Pinheiro, P. J. Ferreira, F. A. Garcia, M. S. Reis and A. C. Pereira et al. An experimental design methodology to evaluate the importance of different parameters on flocculation by polyelectrolytes, in POWDER TECHNOLOGY, vol. 238, p. 2-13, 2013. U. Sakulkhu, H. Hofmann (Dir.). Preparation of Coated Nanoparticles and Investigation of their Behavior in Biological Environment. EPFL, Lausanne, 2013.