个人简介

张洁，副研究员，硕士生导师，2001年7月在中国地质大学获得化学工程与工艺学士学位；2007年1月在中国科学院大连化学物理研究所获得分析化学博士学位。2007年起，先后在厦门大学和加拿大卫生部从事博士后研究和访问研究。2010年加入城市环境研究所任副研究员至今。目前，主持和参与国家自然科学基金、加拿大CMP项目、中国科学院重要方向性项目以及福建省基金、厦门市基金和宁波市基金等多项省市级课题。目前已经发表SCI论文50余篇，

研究领域

应用系统生物学研究重大疾病和环境污染物健康效应和分子机制；环境流行病学；食品/环境安全监测及评估。

承担科研项目情况(研究经费)： 1) 国家自然科学基金面上项目，21677141，青春期砷暴露干扰雄性大鼠HPT轴内分泌/代谢通路的生殖毒性研究、2017/01-2020/12、在研、主持。 2) 国家自然科学基金青年项目， 21407143、饮水型砷暴露对幼鼠海马和皮质 DNA甲基化/去甲基化过程的影响及干扰机制研究、2015/01-2017/12、在研、主持。 3) 中国科学院青年创新促进会成员， 2015/01-2018/12、40 万元、在研、主持。 4) 中国科学院城市环境研究所青年人才领域前沿项目，IUEZD201401、基于下丘脑-垂体-睾丸性腺轴的PM2.5的内分泌（激素）和代谢干扰效应及其机制研究、2014/09-2017/08、在研、主持。 5) 宁波市科技计划项目，2014A610284、宁波市PM2.5的内分泌和代谢干扰健康风险评估研究、2014/03-2017/03、在研、主持。 6) 广州市环境暴露与健康重点实验室开放基金，GZKLEEH201611，砷的神经毒性效应及相关分子机制研究、在研、主持。 7) 福建省自然科学基金面上项目， 2013J01063、福建省典型酚类环境雌激素的膳食暴露和健康风险、 2013/01-2016/12、已结题、主持。 8) 中国科学院分离分析化学重点实验室开放基金，基于差异蛋白质组学的饮水型砷暴露的神经毒性机制研究、2014/09-2015/09、已结题、主持。 9) 中国科学院知识创新工程重要方向项目， KZCX2-EW-QN408、基于联合组学的全氟辛烷类污染物的人类肝脏细胞毒性研究、2011/01-2013/12、已结题、主持。 10) 厦门市科技计划项目， 3502Z20112017、乳及乳制品中有机污染物的高通量筛查检测技术研究、 2010/01-2012/12、已结题、主持。 11) 中国博士后科学基金（一等），20080430108、前列腺癌的代谢组学研究、2008-2009、已结题、主持。

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

[1] Jie Zhang(*), Liangpo Liu, Xiaofei Wang, Qingyu Huang, Meiping Tian, and Heqing Shen(*), Low-Level Environmental Phthalate Exposure Associates with Urine Metabolome Alteration in a Chinese Male Cohort, Environmental Science & Technology, 2016, 50: 5953-60. [2] Xiaofei Wang(#), Jie Zhang(#), Weipan Xu, Qingyu Huang, Liangpo Liu, Meiping Tian, Yankai Xia, Weibing Zhang(*), Heqing Shen(*), Low-level environmental arsenic exposure correlates with unexplained male infertility risk, Science of The Total Environment, 2016, 571: 307-313. [3] Siyuan Peng(#), Jie Zhang(#), Liangpo Liu, Xueqing Zhang, Qingyu Huang, Ambreen Alamdar, Meiping Tian, and Heqing Shen (*), Newborn Meconium and Urinary Metabolome Response to Maternal Gestational Diabetes Mellitus: A Preliminary Case-Control Study, Journal of Proteome Research, 2015, 14, 1799-1809. [4] Xiaoxue Wang, Xiaoli Mu, Jie Zhang*, Qingyu Huang, Ambreen Alamdar, Meiping Tian, Liangpo Liu, and Heqing Shen*, Serum metabolomics reveals arsenic exposure disrupted lipid and amino acid metabolism in rat: a step forward in understanding chronic arsenic toxicity, Metallomics 2015, 7, 544-552. [5] Xiaoxue Wang, Jie Zhang*, Qingyu Huang, Ambreen Alamdar, Meiping Tian, Liangpo Liu, and Heqing Shen*, Serum Metabolomics Analysis Reveals Oral Exposure to Benzo(a)pyrene Impaired Lipid Metabolism in Rats, Molecular Biosystems, 2015, 11, 753-759. [6] Jie Zhang, Heqing Shen*, Weipan Xu, Yankai Xia, Dana Boyd Barr, Xiaoli Mu, Xiaoxue Wang, Liangpo Liu, Qingyu Huang, and Meiping Tian, Urinary Metabolomics Revealed Arsenic Internal Dose-related Metabolic Alterations: a Proof-of-Concept Study in a Chinese Male Cohort, Environmental Science & Technology, 2014, 48(20): 12265-12274. [7] Jie Zhang, Zhenzhen Huang, Yankai Xia, Francis L Martin, Wei Hang, and Heqing Shen*, Metabolomic Analysis Reveals a Unique Urinary Pattern in Normozoospermic Infertile Men, Journal of Proteome Research, 2014, 13(6): 3088-3099. [8] Jie Zhang, Zhenzhen Huang, Minjian Chen, Yankai Xia, Francis L Martin, Weipan Xu, Wei Hang, and Heqing Shen*, Urinary Metabolome Identifies Signatures of Oligozoospermic Infertile Men, Fertility and Sterility, 2014, 102(1): 44-53. [9] Jie Zhang*, Xiaoli Mu, Weipan Xu, Francis L. Martin, Ambreen Alamdar, Liangpo Liu, Meiping Tian, Qingyu Huang, and Heqing Shen*, Exposure to Arsenic via Drinking Water Induces 5-Hydroxymethylcytosine Alteration in Rat, Science of Total Environment, 2014, 497: 618-625. [10] Qingyu Huang, Jie Zhang*, Siyuan Peng, and Heqing Shen*, Proteomic Analysis of Apoptosis-Related Proteins in Human Hepatic Cells (L-02) Exposed to Perfluorooctane Sulfonate Using iTRAQ Technique, Journal of Applied Toxicology, 2014, 34(12): 1342-1351. [11] Qingyu Huang, Jie Zhang*, Siyuan Peng, Meiping Tian, Jinsheng Chen, and Heqing Shen*, Effects of Water Soluble PM2.5 Extracts Exposure on Human Lung Epithelialcells (A549): a Proteomic Study, Journal of Applied Toxicology, 2014, 34(6): 675-687. [12] Qingyu Huang, Lianzhong Luo, Ambreen Alamdar, Jie Zhang, Liangpo Liu, Meiping Tian, Syed Ali Musstjab Akber Shah Eqani1, Heqing Shen*, Integrated proteomics and metabolomics analysis of rat testis: Mechanism of arsenic-induced male reproductive toxicity, Scientific Report, 2016, DOI: 10.1038/srep32518. [13] Yulei Wang, Jie Zhang, Xiaojia Huang*, and Dongxing Yuan, Preparation of Stir Cake Sorptive Extraction Based on Polymeric Ionic Liquid for the Enrichment of Benzimidazole Anthelmintics in Water, Honey and Milk Samples, Analytica Chimica Acta, 2014, 840: 33-41. [14] Meiping Tian, Huaqiong Bao, Francis L. Martin, Jie Zhang, Liangpo Liu, Qingyu Huang, and Heqing Shen*, Association of DNA Methylation and Mitochondrial DNA Copy Number with Human Semen Quality, Biology of Reproduction, 2014, 91(4): 101. [15] Liangpo Liu, Tongwei Xia, Xueqin Zhang, Dana Boyd Barr, Ambreen Alamdar, Jie Zhang, Meiping Tian, Qingyu Huang, and Heqing Shen*, Biomonitoring of Infant Exposure to Phenolic Endocrine Disruptors Using Urine Expressed from Disposable Gel Diapers, Analytical and Bioanalytical Chemistry, 2014, 406(20): 5049-5054. [16] Qingyu Huang, Jie Zhang*, Francis L Martin, Siyuan Peng, Meiping Tian, Xiaoli Mu, and Heqing Shen*, Perfluorooctanoic Acid Induces Apoptosis through The p53-Dependent Mitochondrial Pathway in Human Hepatic Cells: A Proteomic Study, Toxicology Letters, 2013, 223(2): 211-220. [17] Siyuan Peng, Lijuan Yan, Jie Zhang*, Zhanlin Wang, Meiping Tian, and Heqing Shen*, An Integrated Metabonomics and Transcriptomics Approach to Understanding Metabolic Pathway Disturbance Induced by Perfluorooctanoic acid, Journal of Pharmaceutical and Biomedical Analysis, 2013, 86: 56-64. [18] Heqing Shen, Weipan Xu, Jie Zhang, Minjian Chen, Francis L Martin, Yankai Xia, Liangpo Liu, Sijun Dong, and Yongguan Zhu*, Urinary Metabolic Biomarkers Link Oxidative Stress Indicators Associated with General Arsenic Exposure to Male Infertility in a Han Chinese Population. Environmental Science & Technology, 2013, 47(15): 8843-8851. [19] Lijuan Yan, Jie Zhang*, Chensong Pan, Liyi Lin, Xinyi Zhang, and Heqing Shen, High Throughput Screening of Tranquilizers in Dairy Products Using Ultra-Performance Liquid Chromatography Coupled to High Resolution Time-of-Flight Mass Spectrometry, Chinese Journal of Analytical Chemistry, 2013, 41(1): 31-35. [20] Jie Zhang, Lijuan Yan, Meiping Tian, Qingyu Huang, Siyuan Peng, Sijun Dong*, and Heqing Shen*, The Metabonomics of Combined Dietary Exposure to Phthalates and Polychlorinated Biphenyls in Mice, Journal of Pharmaceutical and Biomedical Analysis, 2012, 66: 287-297. [21] Jie Zhang*, Feng Liu, Rongbin Chen, Tao Feng, Sijun Dong, and Heqing Shen*, Levels of Polychlorinated Biphenyls and Organochlorine Pesticides in Edible Shellfish from Xiamen (China) and Estimation of Human Dietary Intake, Food and Chemical Toxicology, 2012, 50(12): 4285-4291. [22] Siyuan Peng, Jie Zhang*, Meiping Tian, Zhanlin Wang, and Heqing Shen, Determination of Global DNA Methylation in Biological Samples by Liquid Chromatography-Tandem Mass Spectrometry, Chinese Journal of Analytical Chemistry, 2012, 40(8): 1201-1206. [23] Xuliang Cao*, Jie Zhang, Cynthia G. Goodyer, Stephen Hayward, Gerard M. Cooke, and Ivan H.A. Curran, Bisphenol A in Human Placental and Fetal Liver Tissues Collected from Greater Montreal Area (Quebec) During 1998–2008, Chemosphere, 2012, 89(5): 505-511. [24] Meiping Tian, Siyuan Peng, Francis L. Martin, Jie Zhang, Liangpo Liu, Zhanlin Wang, Sijun Dong, and Heqing Shen*, Perfluorooctanoic Acid Induces Gene Promoter Hypermethylation of Glutathione-S-Transferase Pi in Human Liver L02 Cells, Toxicology, 2012, 296(1-3): 48-55. [25] Liangpo Liu, Huaqiong Bao, Feng Liu, Jie Zhang, and Heqing Shen*, Phthalates Exposure of Chinese Reproductive Age Couples and Its Effect on Male Semen Quality, a Primary Study, Environmental International, 2012, 42, 78-83. [26] Liangpo Liu, Tongwei Xia, Lanyu Cao, Benhua Zhao, Jie Zhang, Sijun Dong, and Heqing Shen*, Expressing Urine From a Gel Disposable Diaper for Biomonitoring Using Phthalates As an Example, Journal of Exposure Science and Environmental Epidemiology, 2012, 22(6): 625-631. [27] Jie Zhang, Gerard M. Cooke, Ivan H.A. Curran, Cynthia G. Goodyer, and Xuliang Cao*, GC–MS Analysis of Bisphenol A in Human Placental and Fetal Liver Samples, Journal of Chromatography B, 2011, 879(2): 209-214. [28] Jinchun Xing, Lijuan Yan, Jie Zhang*, Lin Lin, Yao Gao, Wengui Chen, Xiuyu Song, Xiaomei Yan, Wei Hang(*), and Benli Huang, A Comparative Study of Elution Gradients in UPLC-TOF-MS-Based Metabonomics Research, Chromatographia, 2010, 72(9-10): 807-813. [29] Liang Gao, Jie Zhang, Weibing Zhan, Yichun Shan, Zhen Liang, Lihua Zhang*, Yushu Huo, and Yukui Zhang, Integration of Normal Phase Liquid Chromatography with Supercritical Fluid Chromatography for Analysis of Fruiting Bodies of Ganoderma Lucidum, Journal of Separation Science, 2010, 33(23-24): 3817-3821. [30] Jie Zhang, Lijuan Yan, Wengui Chen, Lin Lin, Xiuyu Song, Xiaomei Yan, Wei Hang*, Benli Huang, Metabonomics Research of Diabetic Nephropathy and Type 2 Diabetes Mellitus Based on UPLC-oaTOF-MS System, Analytica Chimica Acta, 2009, 650(1): 16-22. [31] 张洁，木晓丽，王晓雪，黄清育，田美平，申河清*，砷对DNA甲基化影响的研究进展，环境与健康杂志，2014，31(3)：269-275。 [32] 木晓丽，张洁*，彭思远，王晓雪，申河清，液相色谱？串联质谱法同时测定生物组织全基因组ＤＮＡ甲基化和羟甲基化水平，色谱，2014，32(7)：682-686。 [33] 彭思远，严丽娟，张洁*，申河清，利用代谢组学技术研究全氟辛酸的人肝脏毒性机制，色谱，2012，30(2)：123-127。 [34] 张洁，严丽娟，潘晨松，林立毅，张欣怡，申河清*，超高效液相色谱/高分辨飞行时间质谱法同时检测乳制品中19种抗生素，色谱，2012，30(10)：1031-1037。

学术兼职

目前担任Environ Sci Technol、Environ Int、Chemosphere等知名杂志的审稿专家，中国科学院青年促进会会员。。