个人简介

董四君，博士，研究员，博士生导师。厦门市室内空气与健康重点实验室主任。1990年中国农业大学动物遗传专业毕业，2001年获日本筑波大学系统生物学专业硕士学位，2004年获东京农工大学生物工学专业博士学位。2004-2007年，日本产业技术综合研究所，博士后。2007-2008年，任日本国际统合医科学研究所研究员，从事传统医学的心血管疾病临床应用及环境内分泌干扰物的分子作用机制研究。主持承担有国家自然科学基金面上项目和重大项目课题、中科院知识创新工程重要方向项目、环保部公益项目课题、以及地方和企业科研项目。发表学术论文50余篇，其中SCI论文42篇（他引400余次），获授权国际专利2项，组织国际学术会议3次，《生态毒理学报》编委和厦门大学兼职教授，2014年获得中国科学院BHPB导师科研奖。已培养毕业4名博士和4名硕士生, 其中一名博士获得中科院和北京高教系统优秀毕业生称号, 一名硕士获得国家一等奖学金。

研究领域

环境分子毒理、环境医学、天然活性物质在健康领域的应用

承担科研项目情况(研究经费)： 1.国家自然科学基金重大项目课题，“主要环境介质的污染特征与源汇关系 ” 2.国家自然科学基金面上项目，“结合多种模型系统研究全氟辛烷磺酸的心脏发育毒性” 3.国家自然科学基金面上项目，“从胰岛素信号转导通路探讨BPA促进动脉粥样硬化的作用机制” 4.国家自然科学基金面上项目，“近岸水域盐度影响下的全氟化合物鳃毒性及机制研究” 5.环保部公益性行业科研专项课题 ，“极高持久性和生物蓄积性化学品筛查办法和清单研究” 6.企业横向课题，“酵素液功能成分提取新技术及新产品研发” 7.企业横向课题，“海洋菌多糖复合益生元配方与制备工艺研发”

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.Huang Q, Chen Y, Chi Y, Lin Y, Zhang H, Fang C, Dong S*. Immunotoxic effects of perfluorooctane sulfonate and di(2-ethylhexyl) phthalate on the marine fish Oryzias melastigma. Fish Shellfish Immunol. 2015; 44(1):302-6. 2.Sun X,Lin Y,Huang Q,Shi P,Qiu L,Kang M,Chen Y, Fang C, Ye T, Dong S* Di(2-ethylhexyl) phthalate-induced apoptosis in rat INS-1 cells is dependent on activation of endoplasmic reticulum stress and suppression of antioxidant protection. J Cell Mol Med. 2015; 19(3):581-94. 3.Chen Y, Huang Q, Chen Q, Lin Y, Sun X, Zhang H, Zhu M, Dong S*. The inflammation and estrogen metabolism impacts of polychlorinated biphenyls on endometrial cancer cells. Toxicol In Vitro. 2014; 29(2):308-313. 4.Fang C，Ning B, Waqar AB, Niimi M, Li S, Sato Kane, Shiomi M, Ye T, Sun X, Lin Y, Huang Q, Dong S*, Jianglin Fan. Bisphenol A exposure enhances atherosclerosis in WHHL rabbits. PLOS ONE. 2014; 9(10):e110977. 5.Yu Q, Liu Z, Waqar AB, Ning B, Yang X, Shiomi M, Rosanne M. Crooke, Liu E, Dong S, and Fan J.Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL Rabbits,“ Mediators of Inflammation. 2014. Article ID 979132. 6.Dong S*, Kang M, Wu X, Ye T. Development of a Promising Fish Model (Oryzias melastigma) for Assessing Multiple Responses to Stresses in the Marine Environment. Biomed Res Int. 2014; 2014:563131. 7.Ye T, Kang M, Huang Q, Fang C, Chen Y, Liu L, Dong S*. Accumulation of di(2-ethylhexyl) phthalate causes endocrine-disruptive effects in marine medaka (Oryzias melastigma) embryos. Environ Toxicol. 2014 Jul 28. doi: 10.1002/tox.22028. 8.Lin Y, Sun X, Qiu L, Wei J, Huang Q, Fang C, Ye T, Kang M, Dong S*. Exposure to Bisphenol A Induces Dysfunction of Insulin Secretion and Apoptosis through the Damage of Mitochondria in Rat Insulinoma (INS-1) Cells. Cell Death and Disease 2013, 4, e460. 9.Dong S, Furutani Y, Kimura S, Zhu Y, Kawabata K, Furutani M, Nishikawa T, Tanaka T, Masaki T, Matsuoka R, Kiyama R. Brefeldin A is an estrogenic, Erk1/2-activating component in the extract of Agaricus blazei mycelia. J Agric Food Chem. 2013 61, 128-136 10.Huang Q, Fang C, Chen Y, Wu X, Ye T, Lin Y, Dong S*. Embryonic exposure to low concentration of bisphenol A affects the development of Oryzias melastigma larvae. Environ Sci Pollut Res Int. 2011, 19(7):2506-14. 11.Huang Q, Dong S*, Fang C, Wu X, Ye T, Lin Y. Deep sequencing-based transcriptome profiling analysis of Oryzias melastigma exposed to PFOS. Aquat Toxicol. 2012, 120-121:54-8. 12.Wang J, Liao Y, Fan J, Ye T, Sun X, Dong S*. Apigenin inhibits the expression of IL-6, IL-8, and ICAM-1 in DEHP-stimulated human umbilical vein endothelial cells and in vivo. Inflammation. 2012, 35(4):1466-76. 13.Wu X, Huang Q, Fang C, Ye T, Qiu L, Dong S*. PFOS induced precocious hatching of Oryzias melastigma--from molecular level to individual level. Chemosphere. 2012, 87(7):703-8. 14.Liao Y, Wang J, Huang QS, Fang C, Kiyama R, Shen H, Dong S*. Evaluation of cellular response to perfluorooctane sulfonate in human umbilical vein endothelial cells. Toxicol In Vitro. 2012, 26(3):421-8. 15.Fang C, Wu X, Huang Q, Liao Y, Liu L, Qiu L, Shen H, Dong S*. PFOS elicits transcriptional responses of the ER, AHR and PPAR pathways in Oryzias melastigma in a stage-specific manner. Aquat Toxicol. 2012, 106-107:9-19. 16.Dong S, et al. Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract .Microbiol Res. 2012, 167(4):231-7. 17.Wang J, Dong S*. ICAM-1 and IL-8 are expressed by DEHP and suppressed by curcumin through ERK and p38 MAPK in human umbilical vein endothelial cells. Inflammation. 2012, 35(3):859-70. 18.Huang Q, Fang C, Wu X, Fan J, Dong S*. Perfluorooctane sulfonate impairs the cardiac development of a marine medaka (Oryzias melastigma). Aquat Toxicol. 2011, 105(1-2):71-7. 19.Dong S, Terasaka S, Kiyama R. Bisphenol A induces a rapid activation of Erk1/2 through GPR30 in human breast cancer cells. Environ Pollut. 2011, 159(1):212-8. 20.Liao Y, Dong S*. Cai P, Huang QS, Fang C, Kiyama R, Shen H. Flos Lonicerae extracts and chlorogenic acid protect human umbilical vein endothelial cells from the toxic damage of perfluorooctane sulphonate. Inflammation 2013;36(3):767-79 21.Fang C, Wu X, Huang Q, Liao Y, Liu L, Qiu L, Shen H, Dong S*. Embryonic exposure to PFOS induced immunosuppression in the fish larvae of marine medaka . Ecotoxicology and Environmental Safety 2013 Jun;92:104-11. 22.Ye T, Kang M, Huang Q, Dong S*. Exposure to DEHP and MEHP from hatching to adulthood causes reproductive dysfunction and endocrine disruption in marine medaka (Oryzias melastigma).Aquat Toxicol. 2014 Jan;146:115-26 23.Lin Y，Huang Q, Fang C, Wu X, Fan J, Dong S*. The combined effects of DEHP and PCBs on the phospholipase in mice model. Environmental Toxicology 2013 Jun 26. doi: 10.1002/tox.21885. 24.Shen H, Xu W, Zhang J, Chen M, Martin FL, Xia Y, Liu L, Dong S, Zhu YG. Urinary metabolic biomarkers link oxidative stress indicators associated with general arsenic exposure to male infertility in a han chinese population. Environ Sci Technol. 2013 ;47(15):8843-51. 25.Dong S, Kiyama R. Characterization of Estrogenic Activity of Ginsenosides in MCF-7 Cells using a Customized DNA Microarray. Food Chem. 2009. 113: 672-678. 26.Dong S, Ying S, Kojima T, Shiraiwa M, Mechin MC, et. al. Crucial Role of MZF1 and Sp1 for the transcriptional regulation of the Peptidylarginine Deiminase Type I Gene (PADI1) in Human Keratinocytes. Journal of Investigative Dermatology 2008.128(3):549-557. 27.Dong S, Inoue A, Zhu Y, Tanji M, Kiyama R. Activation of rapid signaling pathways and the subsequent transcriptional regulation for the proliferation of breast cancer MCF-7 cells by the treatment with an extract of glycyrrhiza glabra root. Food and Chemical Toxicology 2007. 45: 2470–2478. 28.Dong S, Zhang Z, Takahara H. Estrogen-enhanced PADI4 expression in MCF-7 cells mediated by ER？-promoted transfactors AP-1, NF-Y and SP1. Molecular Endocrinology 2007. 21: 1617-1629 29.Dong S, Kanno T, Yamaki A, Kojima T, Shirawa M, et. al. NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine deiminase type III gene (PADI3) in human keratinocytes. Biochemical Journal 2006.397(3):449-459 30.Dong S, Kojima T, Shiraiwa M, Mechin MC, Chavanas S, Serre G, Simon M, Kawada A, Kawada A, and Takahara H. Regulation of the expression of peptidylarginine deiminase type II gene (PADI2) in human keratinocytes involves Sp1 and Sp3 transcription factors. Journal of Investigative Dermatology 2005. 124(5):1026-1033. 31.Ying S, Dong S, Kawada A, Kojima T, Chavanas S, Mechin MC, Adoue V, Serre G, Simon M, Takahara H. Transcriptional Regulation of Peptidylargine Deiminase Expression in Human Keratinocytes. J Dermatol Sci. 2009. 53(1):2-9. 32.Zhou Y, Kogiso M, Asakawa M, Dong S, Kiyama R, Shimizu T. Antimicrobial Nanotubes as Delivery Vehicles Consisting of Ag-Embedded Peptidic Lipid-Bilayer Membranes. Adv. Mater. 2009. 21, 1-4.