蒲芳 - 中国科学院长春应用化学研究所

个人简介

教育经历 2004--2010 中国科学院长春应用化学研究所无机化学博士 1999--2003 兰州大学化学化工学院化工程与工艺专业学士工作经历 2012.12-- 中国科学院长春应用化学研究所副研究员 2010.04--2012.12 中国科学院长春应用化学研究所助理研究员基金资助国家自然科学基金青年基金(2014-2016) 吉林省科技发展计划项目(2014-2016)

研究领域

1. 研究氨基酸、小肽、蛋白质、核酸、核苷酸等生物分子与金属离子的超分子组装及其在环境、生物成像、疾病治疗及人造光合体系等领域的应用。 2. 利用核酸、核苷酸等生物分子及具有复杂结构的超分子组装体构建生物逻辑运算体系。 3. 构建基于生物分子及功能纳米材料的生物传感器，用于疾病相关生物标记物、环境污染物等的检测。 4. 研究配体对疾病相关蛋白的识别与调控。

近期论文

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1. Pu, F.; Wu, L.; Ran, X.; Ren, J.; Qu, X., G-quartet-based nanostructure for mimicking light-harvesting antenna. Angew. Chem. Int. Ed. 2015, 54, 892-896. (IF: 11.261) 2. Pu, F.; Wu, L.; Ju, E.; Ran, X.; Ren, J.; Qu, X., Artificial light-harvesting material based on self-assembly of coordination polymer nanoparticles. Adv. Funct. Mater. 2014, 24, 4549-4555. (IF: 11.805) 3. Pu, F.; Ren, J.; Qu, X., Nucleic acids and smart materials: advanced building blocks for logic systems. Adv. Mater. 2014, 26, 5742-5757. (IF: 17.493) 4. Pu, F.; Ren, J.; Qu, X., "Plug and play" logic gates based on fluorescence switching regulated by self-assembly of nucleotide and lanthanide ions. ACS Appl. Mater. Interfaces 2014, 6, 9557-9562. (IF: 6.723) 5. Pu, F; Ju, E.; Ren, J.; Qu, X., Multiconfigurable logic gates based on fluorescence switching in adaptive coordination polymer nanoparticles. Adv. Mater. 2014, 26, 1111-1117. (IF: 17.493) 6. Pu, F.; Wang, E.; Jiang, H.; Ren, J., Identification of polyoxometalates as inhibitors of basic fibroblast growth factor. Mol. BioSyst. 2013, 9, 113-120. 7. Pu, F.; Ren, J., Lighting up silica nanotubes transcribed from the submicron structure of a metal–peptide hybrid. Nanotechnology 2013, 24, 375603. 8. Pu, F.; Liu, Z.; Ren, J.; Qu, X., Nucleic acid-mesoporous silica nanoparticle conjugates for keypad lock security operation. Chem. Commun. 2013, 49, 2305-2307. (IF: 6.834) 9. Pu, F.; Liu, X.; Yang, X.; Liu, Z.; Ren, J.; Wang, S.; Qu, X., Versatile fluorescent conjugated polyelectrolyte-capped mesoporous silica nanoparticles for controlled drug delivery and imaging. ChemPlusChem 2013, 78, 656-662. 10. Pu, F.; Liu, X.; Xu, B.; Ren, J.; Qu, X., Miniaturization of metal-biomolecule frameworks based on stereoselective self-assembly and potential application in water treatment and as antibacterial agents. Chem.--Eur. J. 2012, 18, 4322-4328. (IF: 5.731) 11. Pu, F.; Ren, J.; Yang, X.; Qu, X., Multivalued logic gates based on DNA. Chem.--Eur. J. 2011, 17, 9590-9594. (IF: 5.731) 12. Pu, F.; Liu, Z.; Yang, X.; Ren, J.; Qu, X., DNA-based logic gates operating as a biomolecular security device. Chem. Commun. 2011, 47, 6024-6026. (IF: 6.834) 13. Pu, F.; Wang, C.; Hu, D.; Huang, Z.; Ren, J.; Wang, S.; Qu, X., Logic gates and pH sensing devices based on a supramolecular telomere DNA/conjugated polymer system. Mol. BioSyst. 2010, 6, 1928-1932. 14. Pu, F.; Huang, Z.; Ren, J.; Qu, X., DNA/ligand/ion-based ensemble for fluorescence turn on detection of cysteine and histidine with tunable dynamic range. Anal. Chem. 2010, 82, 8211-8216. (IF: 5.636) 15. Pu, F.; Hu, D.; Ren, J.; Wang, S.; Qu, X., Universal platform for sensitive and label-free nuclease assay based on conjugated polymer and DNA/intercalating dye complex. Langmuir 2010, 26, 4540-4545. 16. Pu, F.; Huang, Z.; Hu, D.; Ren, J.; Wang, S.; Qu, X., Sensitive, selective and label-free protein detection using a smart polymeric transducer and aptamer/ligand system. Chem. Commun. 2009, 7357-7359. (IF: 6.834) 17. Ran, X.; Pu, F.;* Ren, J.;* Qu, X., A CuS-based chemical tongue chip for pattern recognition of proteins and antibiotic-resistant bacteria. Chem. Commun. 2015, 51, 2675-2678. 18. Ran, X.; Pu, F.; Ren, J.; Qu, X., DNA-regulated upconverting nanoparticle signal transducers for multivalued logic operation. Small 2014, 10, 1500-1503. 19. Yang, X.; Pu, F.; Chen, C.; Ren, J.; Qu, X., An enzyme-responsive nanocontainer as an intelligent signal-amplification platform for a multiple proteases assay. Chem. Commun. 2012, 48, 11133-11135. 20. Lin, Y.; Tao, Y.; Pu, F.; Ren, J.; Qu, X.., Combination of graphene oxide and thiol-activated DNA metallization for sensitive fluorescence turn-on detection of cysteine and their use for logic gate operations. Adv. Funct. Mater. 2011, 21, 4565-4572. 21. Lin, Y.; Yin, M.; Pu, F.; Ren, J.; Qu, X., DNA-templated silver nanoparticles as a platform for highly sensitive and selective fluorescence turn-on detection of dopamine. Small 2011, 7, 1557-1561. 22. Huang, Z.; Pu, F.; Lin, Y.; Ren, J.; Qu, X., Modulating DNA-templated silver nanoclusters for fluorescence turn-on detection of thiol compounds. Chem. Commun. 2011, 47, 3487-3489. 23. Chen, C.; Pu, F.; Huang, Z.; Liu, Z.; Ren, J.; Qu, X., Stimuli-responsive controlled-release system using quadruplex DNA-capped silica nanocontainers. Nucleic acids research 2011, 39, 1638-1644. 24. Chen, C.; Geng, J.; Pu, F.; Yang, X.; Ren, J.; Qu, X., Polyvalent nucleic acid/mesoporous silica nanoparticle conjugates: dual stimuli-responsive vehicles for intracellular drug delivery. Angew. Chem. Int. Ed. 2011, 50, 882-886. 25. Hu, D.; Pu, F.; Huang, Z.; Ren, J.; Qu, X., A quadruplex-based, label-free, and real-time fluorescence assay for RNase H activity and inhibition. Chem.--Eur. J. 2010, 16, 2605-2610. 26. Ju, E.; Dong, K.; Liu, Z.; Pu, F.; Ren, J.; Qu, X., Tumor microenvironment activated photothermal strategy for precisely controlled ablation of solid tumors upon NIR irradiation. Adv. Funct. Mater. 2015, 25, 1574-1580. 27. Hu, D.; Huang, Z.; Pu, F.; Ren, J.; Qu, X., A label-free, quadruplex-based functional molecular beacon (LFG4-MB) for fluorescence turn-on detection of DNA and nuclease. Chem.--Eur. J. 2011, 17, 1635-1641. 28. Huang, Z.; Pu, F.; Hu, D.; Wang, C.; Ren, J.; Qu, X., Site-specific DNA-programmed growth of fluorescent and functional silver nanoclusters. Chem.--Eur. J. 2011, 17, 3774-3780. 29. Huang, Z.; Tao, Y.; Pu, F.; Ren, J.; Qu, X., Lighting-up single-walled carbon nanotubes with silver nanoclusters. Chem.--Eur. J. 2011, 17, 7745-7749. 30. Lin, Y.; Chen, C.; Wang, C.; Pu, F.; Ren, J.; Qu, X., Silver nanoprobe for sensitive and selective colorimetric detection of dopamine via robust Ag-catechol interaction. Chem. Commun. 2011, 47, 1181-1183. 31. Lin, Y.; Tao, Y.; Ren, J.; Pu, F.; Qu, X., Highly sensitive and selective detection of thiol-containing biomolecules using DNA-templated silver deposition. Biosensors. Bioelectron. 2011, 28, 339-343. 32. Wang, C.; Pu, F.; Lin, Y.; Ren, J.; Dohn, C.; Nakatani, K.; Qu, X., Molecular-glue-triggered DNA assembly to form a robust and photoresponsive nano-network. Chem.--Eur. J. 2011, 17, 8189-8194. 33. Wang, C.; Tao, Y.; Pu, F.; Ren, J.; Qu, X., pH-responsive DNA assembly regulated through A-motif. Soft Matter 2011, 7, 10574-10576. 34. Yang, X.; Pu, F.; Ren, J.; Qu, X., DNA-templated ensemble for label-free and real-time fluorescence turn-on detection of enzymatic/oxidative cleavage of single-stranded DNA. Chem. Commun. 2011, 47, 8133-8135. 35. Huang, Z.; Tao, Y.; Pu, F.; Ren, J.; Qu, X., Versatile logic devices based on programmable DNA-regulated silver-nanocluster signal transducers. Chem.--Eur. J. 2012, 18, 6663-6669. 36. Ju, E.; Yang, X.; Lin, Y.; Pu, F.; Ren, J.; Qu, X., Exonuclease-aided amplification for label-free and fluorescence turn-on DNA detection based on aggregation-induced quenching. Chem. Commun. 2012, 48, 11662-11664. 37. Liu, Z.; Li, M.; Li, Z. H.; Pu, F.; Ren, J. S.; Qu, X. G., Easy access to selective binding and recyclable separation of histidine-tagged proteins using Ni2+-decorated superparamagnetic nanoparticles. Nano Res. 2012, 5, 450-459. 38. Liu, Z.; Li, M.; Pu, F.; Ren, J. S.; Yang, X. J.; Qu, X. G., Hierarchical magnetic core-shell nanoarchitectures: non-linker reagent synthetic route and applications in a biomolecule separation system. J. Mater. Chem. 2012, 22, 2935-2942. 39. Yang, X.; Liu, X.; Liu, Z.; Pu, F.; Ren, J.; Qu, X., Near-infrared light-triggered, targeted drug delivery to cancer cells by aptamer gated nanovehicles. Adv. Mater. 2012, 24, 2890-2895. 40. Liu, Z.; Pu, F.; Huang, S.; Yuan, Q.; Ren, J.; Qu, X., Long-circulating Gd2O3:Yb3+, Er3+ up-conversion nanoprobes as high-performance contrast agents for multi-modality imaging. Biomaterials 2013, 34, 1712-1721. 41. Liu, Z.; Pu, F.; Liu, J.; Jiang, L.; Yuan, Q.; Li, Z.; Ren, J.; Qu, X., PEGylated hybrid ytterbia nanoparticles as high-performance diagnostic probes for in vivo magnetic resonance and X-ray computed tomography imaging with low systemic toxicity. Nanoscale 2013, 5, 4252-4261. 42. Ran, X.; Sun, H.; Pu, F.; Ren, J.; Qu, X., Ag Nanoparticle-decorated graphene quantum dots for label-free, rapid and sensitive detection of Ag(+) and biothiols. Chem. Commun. 2013, 49, 1079-1081. 43. Yang, X.; Liu, Z.; Li, Z.; Pu, F.; Ren, J.; Qu, X., Near-infrared-controlled, targeted hydrophobic drug-delivery system for synergistic cancer therapy. Chem.--Eur. J. 2013, 19, 10388-10394. 书籍 F. Pu, J. Ren, Structure and Stabilization of CGC+ Triplex DNA, in DNA in Supramolecular Chemistry and Nanotechnology, John Wiley & Sons, Ltd, 2015.