个人简介
1999年9月--2003年7月在黑龙江中医药大学药学院攻读学士和硕士学位,2003年9月--2006年7月在北京大学药学院攻读博士学位,2007年1月-2009年7月在中国医学科学院药用植物研究所从事博士后研究,进行提高难溶性药物原人参二醇生物利用度的研究。
研究领域
1. 改善难溶性药物的溶解度及提高生物利用度。
2. 主要进行脂质体、胶束、纳米混悬剂及透皮制剂等给药系统的制备及体内外评价。
近期论文
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1. Mei-Hua Han, Xiu-Wei Yang, et al. Phytochemical studies on the rhizome of Pinellia ternata and quantification of phenylpropanoids in commercial pinellia tuber by RP-HPLC. Chromatographia, 2006, 64 (11-12): 647-653 (IF=1.37)
2. Mei-Hua Han, Xiu-Wei Yang, Yan-Ping Jin. Novel triterpenoid acyl esters and alkaloids from Anoectochilus roxburghii. Phytochemical analysis, 2008, 19: 438-443 (IF=2.45)
3. Mei-Hua Han, Jing Chen, Jian Wang, Shi-Lin Chen, and Xiang-Tao Wang. Blood Compatibility of PAMAM dendrimers and Erythrocyte Protection. Journal of Biomedical Nanotechnology, 2010, 6, 82-92 (IF=7.578)
4. Mei-Hua Han, Jing Chen, Shi-Lin Chen, and Xiang-Tao Wang. Development of a UPLC-ESI-MS/MS Assay for 20 (S)-Protopanaxadiol and Pharmacokinetic Application of Its Two Formulations in Rats. Analytical Sciences, 2010, 26:749-753 (IF=1.403)
5. Meihua Han, Jing Chen, Yuqin Wang, Shilin Chen,Xiangtao Wang. Determination of 20 (S)-Protopanaxadiol in Rat Plasma by LC-MS/MS Method and Its Application to the Pharmacokinetic Study: A Comparative Study of Its Solution and Two Oral Formulations. Journal of Analytical chemistry, 2013, 68 (8): 1-6 (IF=0.812)
6. Meihua Han, Xiaoli Liu, Yifei Guo, Yanhong Wang, Xiangtao Wang. Preparation, characterization, biodistribution and antitumor efficacy of hydroxycamptothecin nanosuspensions. International Journal of Pharmaceutics, 2013, 455: 85- 92 (IF=3.785)
7. Meihua Han, Xin Yu, Yifei Guo, Yanhong Wang, Haixue Kuang, and Xiangtao Wang. Honokiol Nanosuspensions: preparation, increased oral bioavailability and dramatically enhanced biodistribution in the cardio-cerebro-vascular system, Colloids and Surfaces B: Biointerfaces, 2014, 116: 114-120(IF=4.287)
8. Meihua Han, Liqiang Ma, Xin Yu, Zhitao Li, Yifei Guo, Haixue Kuang, Xiangtao Wang. A nanoparticulate drug-delivery system for 20 (S)- protopanaxadiol: formulation, characterization, increased oral bioavailability and antitumor efficacy. Drug delivery, 2015, 7:1-9 (IF=2.202).
9. Meihua Han, Zhitao Li, Yifei Guo, Jian Zhang, and Xiangtao Wang. A nanoparticulate drug-delivery system for glaucocalyxin A: formulation, characterization, increased in vitro, and vivo antitumor activity. Drug delivery, 2015, 26:1-7 (IF=2.202).
10. Yifei Guo, Yanna Zhao, Meihua Han, Jing Zhao, Afang Zhang* and Xiangtao Wang*. Codendrimer from Polyamidoamine (PAMAM) and oligoethylene dendron as a thermoresponsive drug carrier. Bioconjugate Chemistry, 2014, 25: 24-31 (IF= 4.821).
11. Yifei Guo*, Yanna Zhao, Meihua Han, Chunying Hao and Xiangtao Wang*. Codendrimer (PAG) from polyamidoamine (PAMAM) and oligoethylene glycols (OEG) dendron: evaluation as drug carrier. Journal of Materials Chemistry B, 2013, 1: 6078-6084 (IF=6.612).
12. Yifei Guo, Yanna Zhao, Meihua Han, Jing Zhao, Chunying Hao, Xiangkang Wang, Xiangtao Wang*. A Codendrimer of PAMAM decorated with oligoethylene glycol dendrons: synthesis, self-assembly, and application as drug carrier. Soft Matter, 2013, 9: 10306-10311 (IF= 4.151).
13. 韩美华,杨秀伟,靳彦平. 金线莲挥发油成分的GC-MS分析. 天然产物研究与开发,2006,118: 65-68.
14. 韩美华,杨秀伟,钟国跃,等. 鲜半夏中抑制肿瘤坏死因子-α产生的活性成分. 中国中药杂志,2007,32 (17): 1755-1758.
15. 杨秀伟,韩美华,靳彦平. 金线莲化学成分的研究. 中药材,2007,30 (7): 797-800.
16. 杨秀伟,韩美华,陶海燕,等. 微波加工和蒸制杭白菊挥发油成分的GC-MS分析. 中国中药杂志,2007,32 (3): 227-231.
17. 韩美华,陈 婧,陈士林,等. RP-HPLC法测定20 (S)-原人参二醇药质体药物含量及包封率 [J]. 中国中药杂志,2009,34 (9): 1082.
18. 韩美华,陈婧,陈士林,王向涛. 20 (S)-原人参二醇药质体的制备及体外评价 [J]. 中国中药杂志,2010,35 (7): 7-11.
19. 韩美华, 陈婧,陈士林,王向涛. 氢化磷脂制备的原人参二醇药质体的制备及体外评价 [J]. 中国新药杂志,2010,19 (10):888- 891.
20. 陈婧,韩美华,季宇彬,王向涛. 20 (S)-原人参二醇药质体药物含量及包封率的测定 [J]. 中国新药杂志, 2010,19 (10):892-895.