Klok, Harm-Anton - École polytechnique fédérale de Lausanne EPFL - Institute of Chemical Sciences and Engineering

个人简介

Education August 1989 – October 1993 Studies of Chemical Technology, University of Twente (Enschede, The Netherlands) November 1993 – January 1997 Research and teaching assistant in the group of Prof. M. Möller (Organische Chemie III/Makromolekulare Chemie, Universität Ulm, Ulm, Germany) Topic of PhD Thesis: “Supramolecular and polymeric building blocks for the development of optical ion sensors” November 10th, 2004 Habilitation on “Protein-mimetic polypeptides and protein-inspired hybrid block copolymers” and venia legend in macromolecular chemistry (RWTH Aachen, Aachen, Germany) Academic record December 1992 – March 1993 Research stay at the Central Polymer Research Laboratory of BASF AG (Ludwigshafen, Germany) February 1997 – November 1997 Postdoc in the group of Prof. D. N. Reinhoudt (Laboratory of Supramolecular Chemistry and Technology, Department of Chemical Technology), University of Twente (Enschede, The Netherlands) December 1997 – January 1999 Postdoc in the group of Prof. S. I. Stupp (Departments of Materials Science and Engineering and Chemistry), University of Illinois at Urbana-Champaign (Urbana-Champaign, USA) February 1999 – February 2003 Project-leader in the group of Prof. K. Müllen, Max Planck Institute for Polymer Research (Mainz, Germany) March 2003 – September 2008 Assistant Professor (tenure track) and director of the Polymers Laboratory (Institute of Materials), Ecole Polytechnique Fédérale de Lausanne (EPFL) (Lausanne, Switzerland) October 2008 – July 2009 Associate Professor and director of the Polymers Laboratory (Institute of Materials), Ecole Polytechnique Fédérale de Lausanne (EPFL) (Lausanne, Switzerland) January 2009 – June 2012 Director of the Section of Materials Science and Engineering (~ Director of undergraduate studies elsewhere). August 2009 – Full Professor and director of the Polymers Laboratory (Institute of Materials and Institute of Chemical Sciences and Engineering), Ecole Polytechnique Fédérale de Lausanne (EPFL) (Lausanne, Switzerland) July 2012 – Director, Institute of Materials (EPFL) (~ Department head elsewhere).

研究领域

Materials & synthetic strategies: Peptide/protein-based materials and peptide/protein-polymer hybrids; Surface-initiated polymerization and polymer brushes; Controlled/”living” polymerization and macromolecular engineering; Dendritic and hyperbranched polymers. Fields of application: Polymer therapeutics/Nanomedicine; Smart hydrogels; Controlled drug delivery and release systems; Polymer surface modification; Biomaterials coatings; Protein microarrays; Biomineralization; Environmental sensors.

近期论文

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T. N. Gevrek, T. Bilgic, H.-A. Klok and A. Sanyal. Maleimide-Functionalized Thiol Reactive Copolymer Brushes: Fabrication and Post-Polymerization Modification, in Macromolecules, vol. 47, num. 22, p. 7842-7851, 2014. S. Desseaux and H.-A. Klok. Temperature-Controlled Masking/Unmasking of Cell-Adhesive Cues with Poly(ethylene glycol) Methacrylate Based Brushes, in Biomacromolecules, vol. 15, num. 10, p. 3859-3865, 2014. C. Sugnaux and H.-A. Klok. Glucose-Sensitive QCM-Sensors Via Direct Surface RAFT Polymerization, in Macromolecular Rapid Communications, vol. 35, num. 16, p. 1402-1407, 2014. B. P. Koiry, H.-A. Klok and N. K. Singha. Copolymerization of 2,2,3,3,4,4,4-heptafluorobutyl acrylate with butyl acrylate via RAFT polymerization, in Journal Of Fluorine Chemistry, vol. 165, p. 109-115, 2014. B. R. Coad, T. Bilgic and H.-A. Klok. Polymer Brush Gradients Grafted from Plasma-Polymerized Surfaces, in Langmuir, vol. 30, num. 28, p. 8357-8365, 2014. T. Steinbach, F. Wurm and H.-A. Klok. Squaric acid mediated bioconjugation expanded to polymers prepared by ATRP, in Polymer Chemistry, vol. 5, num. 13, p. 4039-4047, 2014. H. Wutzel, F. H. Richter, Y. Li, S. S. Sheiko and H.-A. Klok. Poly[N-(2-hydroxypropyl)methacrylamide] nanogels by RAFT polymerization in inverse emulsion, in Polymer Chemistry, vol. 5, num. 5, p. 1711-1719, 2014. M. Nassajian Moghadam, V. Kolesov, H.-A. Klok and D. Pioletti. Controlled release from a mechanically-stimulated thermosensitive self-heating composite hydrogel, in Biomaterials, vol. 35, p. 450-455, 2014. F. Wurm, T. Steinbach and H.-A. Klok. One-pot squaric acid diester mediated aqueous protein conjugation, in Chemical Communications, vol. 49, num. 71, p. 7815-7817, 2013. R. Barbey, V. Laporte, S. Alnabulsi and H.-A. Klok. Postpolymerization Modification of Poly(glycidyl methacrylate) Brushes: An XPS Depth-Profiling Study, in Macromolecules, vol. 46, num. 15, p. 6151-6158, 2013. C. Sugnaux, L. Lavanant and H.-A. Klok. Aqueous Fabrication of pH-Gated, Polymer-Brush-Modified Alumina Hybrid Membranes, in Langmuir, vol. 29, num. 24, p. 7325-7333, 2013. C. Dingels, F. Wurm, M. Wagner, H.-A. Klok and H. Frey. Squaric Acid Mediated Chemoselective PEGylation of Proteins: Reactivity of Single-Step-Activated alpha-Amino Poly(ethylene glycol)s, in Chemistry-A European Journal, vol. 18, num. 52, p. 16828-16835, 2012. N. Schuewer, M.-L. Tercier-Waeber, M. Danial and H.-A. Klok. Voltammetric Detection of Hg2+ Using Peptide-Functionalized Polymer Brushes, in Australian Journal Of Chemistry, vol. 65, num. 8, p. 1104-1109, 2012. D. Paripovic, H. Hall-Bozic and H.-A. Klok. Osteoconductive surfaces generated from peptide functionalized poly(2-hydroxyethyl methacrylate-co-2-(methacryloyloxy)ethyl phosphate) brushes, in Journal Of Materials Chemistry, vol. 22, num. 37, p. 19570-19578, 2012. M. Danial, V. Dulmen, H. H. Tim, J. Aleksandrowicz and A. J. G. Poetgens et al. Site-Specific PEGylation of HR2 Peptides: Effects of PEG Conjugation Position and Chain Length on HIV-1 Membrane Fusion Inhibition and Proteolytic Degradation, in Bioconjugate Chemistry, vol. 23, num. 8, p. 1648-1660, 2012. Z. Kadlecova, L. Baldi, D. Hacker, F. M. Wurm and H.-A. Klok. Comparative Study on the In Vitro Cytotoxicity of Linear, Dendritic, and Hyperbranched Polylysine Analogues, in Biomacromolecules, vol. 13, num. 10, p. 3127-3137, 2012. M. Geissbuehler, Z. Kadlecova, H.-A. Klok and T. Lasser. Assessment of transferrin recycling by Triplet Lifetime Imaging in living cells, in Biomedical Optics Express, vol. 3, num. 10, p. 2526-2536, 2012. K. A. Guenay, N. Schuewer and H.-A. Klok. Synthesis and post-polymerization modification of poly(pentafluorophenyl methacrylate) brushes, in Polymer Chemistry, vol. 3, p. 2186-2192, 2012. Z. Kadlecova, Y. Rajendra, M. Matasci, D. Hacker and L. Baldi et al. Hyperbranched Polylysine: A Versatile, Biodegradable Transfection Agent for the Production of Recombinant Proteins by Transient Gene Expression and the Transfection of Primary Cells, in Macromolecular Bioscience, vol. 12, p. 794-804, 2012.