个人简介
2003.9-2006.7 就读于黑龙江中医药大学,获中药学专业理学博士学位,主要进行中药血清药化学研究。
2006.10-2008.10于清华大学进行博士后研究工作,从事新型制剂开发及中药复方的代谢组学研究,主持完成中国博士后科学基金“中药双龙方PK-PD动态多维时空网络模式建立”,并作为分课题负责人参与完成国家十一五科技支撑计划“中药复方作用和配伍评价研究(2006BAI08B04-01)的分课题:中药双龙方的系统生物学评价研究”;国家自然科学基金“中药干预骨髓间质干细胞向心肌细胞定向分化的分子机制研究(30500680)”
2008年至今工作于中国医学科学院药用植物研究所,任药用植物研究所云南分所副所长,国家自然科学基金一审评审专家。
研究领域
1、中药或天然产物血清药化学研究;
2、基于药物吸收、转运、代谢的药物相互作用研究;
3、中药代谢组学研究。
近期论文
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1. Juan Lu, Xia Zhan, Qingfei Liu, Xi Chen*, Xinge Zhao,Yiming Wang, Guoan Luo. Studies on tissue distribution of scutella rin and methyl polyethylene glycol (mPEG)-scu tellarin prodrug in mice Acta Pharmaceutica Sinica B 2012;2(3):274 – 277。
2. Juan Lu*, Jia-Zhang Qin, Ping Chen, Xi Chen, Ying-Zhi Zhangand Si-Jia Zhao. Quality difference study of six varieties of Ganoderma lucidum with different origins. Frontiers in pharmacology.2012,3:1-5
3. Haitao Lv,Lian Liu,Gustavo Palaciosa and Xi Chen* .Metabolomic analysis characterizes tissue specific indomethacin-induced metabolic perturbations of rats.Analyst, 2011, 136, 2260-2269
4. Xi Chen*. Protective effects of quercetin on liver injury induced by ethanol. Pharmacognosy Magazine [Phcog Mag.] . 2010, 6:135-141
5. Haitao Lv, Lian Liu, Yingzhi Zhang, Ting Song, Juan Lu and Xi Chen*. Ingenuity pathways analysis of urine metabonomics phenotypes toxicity of gentamicin in multiple organs.Molecular BioSystems.2010, 6, 2056-2067
6. Xi Chen*,Lian Liu,Gustavo Palacios,Jie Gao,Ning Zhang,Guang Li,Juan Lu1,Ting Song,Yingzhi Zhang,Haitao Lv .Plasma metabolomics reveals biomarkers of the atherosclerosis. Journal of Separaction Science 2010,33,2776–2783
7. Hongxin Cao, Xi Chen, Hui Suna, Tetsuro Sakurai, Jue Zhou,Wenjun Sun, Haitao Lv, Xijun Wang. Pharmacokinetics-based elucidation on disparity in clinical effectiveness between varieties of ZhiZhuWan, a Traditional Chinese Medical formula. Journal of Ethnopharmacology. 2010,28: 606–610
8. Liang X, Chen X, Liang Q, Zhang H, Hu P, Wang Y, Luo G.Metabonomic study of Chinese medicine Shuanglong formula as an effective treatment for myocardial infarction in rats.J Proteome Res. 2011 Feb 4;10(2):790-9.
9. 陈曦,雷勇,张宁,王业秋,逄居龙. 柱前衍生-反相高效液相色谱测定牛磺罗定及固体制剂含量,分析科学学报,2011,27(3):339-342
10. 张宁,雷勇,任燕冬,陈曦*.表面响应曲面法优化牛磺罗定衍生化条件的研究.药物分析杂志, 2011,31( 3):479-483
11. 陈曦,夏珂,张宁,王业秋,祁永华. 昼夜给予逍遥散对慢性肝损伤大鼠的保护作用,中药药理与临床 2010;26( 6):3-5
12.Duan X, Liu Q, Zhang Y, Bi K, Chen X, Wang Y, Luo G. Development of monolithic osmotic pump tablet system for isosorbide-5-mononitrate delivery and evaluation of it in vitro and in vivo.Drug Dev Ind Pharm. 2009 Apr;35(4):499-507.
13. Cong W, Liu Q, Chen X, Gao R, Lu J, Wang Y, Luo G.Characterization and pharmacokinetics of a novel pirarubicin liposome powder.Drug Dev Ind Pharm. 2010 Oct;36(10):1186-94.