谢勇 - 中国医学科学院药用植物研究所 -

个人简介

2000.4.-2005.3 在日本国立大阪大学研究生院物质化学专业学习。2005年3月获得博士学位。主要从事含铜或含锰离子的蛋白质的结构与功能研究。 2005.4.-2007.11 在日本理化学研究所基因科学研究中心任助理研究员，承担日本国家基础研究项目《蛋白质基本结构的系统分析》中嗜热古细菌Thermus Thermophilus HB8、Pyrococcus horokoshii OT3和高等动物来源蛋白质的空间结构特征的研究。 2007.12-2009.5 在日本高能量加速器研究机构结构生物学研究中心任研究员。承担日本国家基础研究项目《药物作用靶点蛋白质的结构生物学研究》中控制细胞内蛋白质输运的蛋白质-蛋白质复合体的结构研究。迄今发表SCI论文9篇。对脱氮菌Hyphomicrobium denitrificans体内的特殊亚硝酸还原酶的结构与功能研究中的单独完成它的空间结构研究，研究论文发表在著名科技期刊《美国科学院院刊（PNAS）》上。2009年6月作为药用植物研究所引进人才到药理毒理研究中心工作，任副研究员、硕士研究生导师。

研究领域

1) 结核杆菌H37Rv体内潜在的药物作用靶点蛋白质的空间结构研究； 2）与DNA相互作用蛋白质的结构与功能研究； 3）同功酶空间结构多样性研究。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

(1) Masaki Nojiri*, Yong Xie*, Tsuyoshi Inoue, Takahiko Yamamoto, Hiroyoshi Matsumura, Kunishige Kataoka, Deligeer, Kazuya Yamaguchi, Yasushi Kai, and Shinnichirou Suzuki. Structure and function of a novel hexameric copper-containing nitrite reductase. Proc. Natl. Acad. Sci. USA. 104, (2007), 4315-4320. *These authors contributed equally to this work。 (2) Yong Xie, Chie Takemoto, Seiichiro Kishishita, Tomomi Uchikubo, Kazutaka Murayama, Lirong Chen, Zhi-Jie Liu, Bi-Cheng Wang, Miho Manzoku, Akio Ebihara, Seiki Kuramitsu, Mikako Shirozu, and Shigeyuki Yokoyama. Crystal structure of the minimized????-hydrolase fold frotein from Thermus Thermophilus HB8. Acta Cryst. F63, (2007), 993-997. (3) Yong Xie, Tsuyoshi Inoue, Youichi Miyamoto, Hiroyoshi Matsumura, Kunishige Kataoka, Kazuya Yamaguchi, Shinnichirou Suzuki, and Yasushi Kai. Structural Reorganization of the Copper Binding Site Involving Thr15 of Macyanin from Cucurbita pepo medullosa (Zucchini) upon Reduction. J. Biochem. 137, (2005), 455-461. (4) Yong Xie, Tsuyoshi Inoue, Nozomu Seike, Hiroyoshi Matsumura, Koji Kanbayashi, Deligeer, Koushi Itoh, Kunishige Kataoka, Kazuya Yamaguchi, Shinnichirou Suzuki, and Yasushi Kai. Crystallization and Preliminary X-ray Crystallographic Studies of Dissimilatory Nitrite Reductase isolated from Hyphomicrobium denitrificans A315. Acta Cryst. D60, (2004), 2383-2386. (5) Yong Xie, Tsuyoshi Inoue, Youichi Miyamoto, Hiroyoshi Matsumura, Kunishige Kataoka, Kazuya Yamaguchi, Shinnichirou Suzuki, and Yasushi Kai. Crystallization and preliminary X-ray crystallographic studies of mavicyanin from Cucurbita pepo medullosa. Acta Cryst. D59, (2003), 1474-1476. (6) Hiroyoshi Matsumura, Yong Xie, Shunsuke Shirakata, Tsuyoshi Inoue, Takeo Yoshinaga, Yoshihisa Ueno, Katsura Izui, and Yasushi Kai. Crystal Structures of C4 Form Maize andQuaternary Complex of E. coli Phosphoenolpyruvate Carboxylases. Structure 10, (2002), 1721-1730. (7) Tsuyoshi Inoue, Shinnichiro Suzuki, Nobuya Nishio, Kazuya Yamaguchi, Jiro Tobari, Xie yong, Sawako Hamanaka, Hiroyoshi Matsumura, Yasushi Kai. The Significant of the Flexible Loop in the Azurin (Az-Iso2) from the Obligate Methylotroph Methylomonas sp. Strain J. J. Mol. Biol. 333, (2003), 117-124. (8) Yousuke Okano, Eiichi Mizohata, Yong Xie, Hiroyoshi Matsumura, Hajime Sugawara, Tsuyoshi Inoue, Akiho Yokota, and Yasushi Kai. X-ray Structure of Galdieria Rubisco Complexed with One Sulfate Ion per Activite Site. FEBS letters 527, (2002), 33-36. (9) Heitato Yamane, Yasuo Nakao, Satoru Kawabe, Yong Xie, Nobuko Kanehisa, Yasushi Kai, Masashi Kinosita, Wasuke Mori, and Yasushisa Hayashi. Synthesis, Structures and [(1-ethyl-2-benzimidzolyl)-methyl]-2-hydroxy- 1,3-diaminopropane and their Urea Complexes Relevant to the Urease Active Site. Bulletin of the Chemical Society of Japan 74, (2001), 2107-2112.