个人简介
2004.9-2006.7 就读于中国药科大学，获药物代谢动力学专业理学博士学位，主要进行疾病模式下血脑屏障药物转运研究，荣获“中国药科大学优秀博士毕业生”嘉奖。
2006.7-2008.5于中国医学科学院进行博士后研究工作，从事创新药物及中药复方的药物代谢动力学研究，主持完成医科院青年基金“抗脑缺血新药匹诺塞林的代谢机制研究（2006QN38）”，并作为主要参加人参与完成“重大新药创制”快速体外药物代谢动力学ADME/T筛选平台的建设和研究工作。
2008年至今工作于中国医学科学院药用植物研究所。
研究领域
1、中药或天然产物临床前药物代谢动力学研究；
2、基于药物吸收、转运、代谢的药物相互作用研究；
3、中药复方配伍的药代机制研究。
近期论文
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1. Zhi-Hong Yang, Xiao Sun, Yun Qi, Chao Mei, Xiao-Bo Sun, Guan-Hua Du. Uptake characteristics of pinocembrin and its effect on p-glycoprotein at the blood-brain barrier in in vitro experiments. Journal of Asian Natural Products Research. 2012, 14(1): 14-21.
2. Zhi-Hong Yang, Xiao Sun, Chao Mei, Xiao-Bo Sun, Xiao-Dong Liu, Qi Chang. An in vitro transport model for rapid screening and predicting the permeability of candidate compounds at blood-brain barrier. Journal of Asian Natural Products Research. 2011, 13(12): 1087-1097.
3. Dan Yao, Zhi-Hong Yang, Li Liu, Jia Li, Yun-Li Yu, Lu-Lu Zhang, Xian Pan, Xiao-Dong Liu, Guang-Ji Wang. Verapamil exerts biphasic modulation on Phenobarbital transport across the blood-brain barrier: evidence from an in vivo and in vitro study. Naunyn-Schmiedeberg’s Archives of Pharmacology. 2011, 383(4): 393-402.
4. Zhang Jianpei, Yang Zhihong*. Mining top-k fault tolerant association rules by redundant pattern disambiguation in data streams. 2010 IEEE (2010 International Conference on Intelligent Computing and Cognitive Informatics, Kuala Lumpur, Malaysia). EI: 20104313331535.
5. Zhang Jianpei, Yang Zhihong*. Mining top-k fault tolerant frequent patterns with sliding windows in data streams. 2010 IEEE, (2010 International Conference on Intelligent Computing and Cognitive Informatics, Kuala Lumpur, Malaysia). EI: 20104313331445.
6. Qing-shan Liu, Jin-hua Wang, Jian Cui, Zhi-hong Yang, Guan-hua Du. A novel acute anemia model for pharmacological research in mice by compelled acute exercise. Acta Pharmacologica Sinica. 2009, 30(12): 1643-1647.
7. Zhihong Yang, Rui Liu, Xiaoxiu Li, Shuo Tian, Qingshan Liu, Guanhua Du. Development and validation of a high-performance liquid chromatographic method for determination of pinocembrin in rat plasma: Application to the pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis. 2009, 49(5): 1277-1281.
8. Rui Liu, Mei Gao, Zhi-Hong Yang, Guan-Hua Du. Pinocembrin protects rat brain against oxidation and apoptosis induced by ischemia-reperfusion both in vivo and in vitro. Brain Research. 2008, 1216, 104-115.
9. Liu Xiao-Dong, Yang Zhi-Hong, Yang Hui-Wen. Repetitive/temporal hypoxia increased P-glycoprotein expression in cultured rat brain microvascular endothelial cells in vitro. Neuroscience Letters. 2008, 432(3): 184-187.
10. Zhi-Hong Yang, Xiao-Dong Liu. P-glycoprotein-mediated efflux of phenobarbital at the blood-brain barrier evidence from transport experiments in vitro. Epilepsy Research. 2008, 78(1): 40-49.
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