Johnsson, Kai - École polytechnique fédérale de Lausanne EPFL - Institute of Chemical Sciences and Engineering

个人简介

Kai Johnsson is Associate Editor of ACS Chemical Biology since 2005. He is member of the Editorial Advisory Board of Science and of the Research Council of the Swiss National Science Foundation. He is co-founder of Covalys Biosciences which was based on protein labeling technologies developed in his laboratory; these technologies are now available through New England BioLabs. He received the Prix APLE for the invention of the year 2003 of EPFL, the Novartis Lectureship Award 2012/13 and is elected member of EMBO.

研究领域

Kai Johnsson is Full Professor at the Institute of Chemical Sciences and Engineering of the École Polytechnique Fédérale de Lausanne (EPFL) and co-director of the NCCR Chemical Biology. His current research interests are the development and application of chemical approaches to study and manipulate protein function. His past achievements include the introduction of different approaches to specifically label proteins in living cells; among these the SNAP-tag and CLIP-tag have become popular in the biological community.

近期论文

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Activatable fluorescent probes for hydrolase enzymes based on coumarin-hemicyanine hybrid fluorophores with large Stokes shifts H. Fujioka; S-n. Uno; M. Kamiya; R. Kojima; K. Johnsson et al. Chemical Communications. 2020-05-25. Vol. 56, num. 42, p. 5617-5620. DOI : 10.1039/d0cc00559b. SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand H. Farrants; V. A. Gutzeit; A. Acosta-Ruiz; D. Trauner; K. Johnsson et al. Acs Chemical Biology. 2018-09-01. Vol. 13, num. 9, p. 2682-2688. DOI : 10.1021/acschembio.8b00628. Luciferases with tunable emission wavelengths K. Johnsson; J. Hiblot; Q. Yu; M. Sabbadini; L. Reymond et al. Angewandte Chemie International Edition. 2017. Vol. 56, num. 46, p. 14556-14560. DOI : 10.1002/anie.201708277. Bioluminescent Antibodies for Point-of-Care Diagnostics L. Xue; Q. Yu; R. Griss; A. Schena; K. Johnsson Angewandte Chemie International Edition. 2017. Vol. 56, num. 25, p. 7112-7116. DOI : 10.1002/anie.201702403. Chemical Genetic Screen Identifies Natural Products that Modulate Centriole Number M. Graciotti; Z. Fang; K. Johnsson; P. Gönczy ChemBioChem. 2016. Vol. 17, num. 21, p. 2063-2074. DOI : 10.1002/cbic.201600327. A General Strategy for the Semisynthesis of Ratiometric Fluorescent Sensor Proteins with Increased Dynamic Range L. Xue; E. Prifti; K. Johnsson Journal of the American Chemical Society. 2016. Vol. 138, num. 16, p. 5258-5261. DOI : 10.1021/jacs.6b03034. Tetrahydrobiopterin Biosynthesis as a Potential Target of the Kynurenine Pathway Metabolite Xanthurenic Acid H. Haruki; R. Hovius; M. G. Pedersen; K. Johnsson Journal Of Biological Chemistry. 2015. Vol. 291, num. 2, p. 652-657. DOI : 10.1074/jbc.C115.680488. Imaging and manipulating proteins in live cells through covalent labeling L. Xue; I. A. Karpenko; J. Hiblot; K. Johnsson Nature Chemical Biology. 2015. Vol. 11, num. 12, p. 917-923. DOI : 10.1038/nchembio.1959. Modulating protein activity using tethered ligands with mutually exclusive binding sites A. Schena; R. Griss; K. Johnsson Nature Communications. 2015. Vol. 6, p. 7830. DOI : 10.1038/ncomms8830. FLUORESCENCE MICROSCOPY Strategic blinking G. Lukinavicius; K. Johnsson Nature Chemistry. 2014. Vol. 6, num. 8, p. 663-664. DOI : 10.1038/nchem.2020. Yeast Three-Hybrid Screening for Identifying Anti-Tuberculosis Drug Targets S. Moser; K. Johnsson Chembiochem. 2013. Vol. 14, num. 17, p. 2239-2242. DOI : 10.1002/cbic.201300472. Sensing Acetylcholine and Anticholinesterase Compounds A. Schena; K. Johnsson Angewandte Chemie-International Edition. 2013. Vol. 53, num. 5, p. 1302-1305. DOI : 10.1002/anie.201307754. Commercial Cdk1 antibodies recognize the centrosomal protein Cep152 G. Lukinavičius; D. Lavogina; P. Gönczy; K. Johnsson Biotechniques. 2013. Vol. 55, num. 3, p. 111-114. DOI : 10.2144/000114074. Tetrahydrobiopterin Biosynthesis as an Off-Target of Sulfa Drugs H. Haruki; M. G. Pedersen; K. I. Gorska; F. Pojer; K. Johnsson Science. 2013. Vol. 340, num. 6135, p. 987-991. DOI : 10.1126/science.1232972. Investigating Endocytic Pathways to the Endoplasmic Reticulum and to the Cytosol Using SNAP-Trap R. Geiger; S. Luisoni; K. Johnsson; U. F. Greber; A. Helenius Traffic. 2013. Vol. 14, num. 1, p. 36-46. DOI : 10.1111/tra.12018. Protein tag-mediated conjugation of oligonucleotides to recombinant affinity binders for proximity ligation G. J. Gu; M. Friedman; C. Jost; K. Johnsson; M. Kamali-Moghaddam et al.New Biotechnology. 2013. Vol. 30, num. 2, p. 144-152. DOI : 10.1016/j.nbt.2012.05.005. A Fluorescent Sensor for GABA and Synthetic GABA(B) Receptor Ligands A. Masharina; L. Reymond; D. Maure; K. Umezawa; K. Johnsson Journal Of The American Chemical Society. 2012. Vol. 134, num. 46, p. 19026-19034. DOI : 10.1021/ja306320s. Exploiting Ligand-Protein Conjugates to Monitor Ligand-Receptor Interactions H. Haruki; M. R. Gonzalez; K. Johnsson Plos One. 2012. Vol. 7, num. 5, p. e37598. DOI : 10.1371/journal.pone.0037598. A Caged, Localizable Rhodamine Derivative for Superresolution Microscopy S. Banala; D. Maurel; S. Manley; K. Johnsson ACS Chemical Biology. 2012. Vol. 7, num. 2, p. 289-293. DOI : 10.1021/cb2002889.