Hubbell, Jeffrey A. - École polytechnique fédérale de Lausanne EPFL - Institute of Chemical Sciences and Engineering

个人简介

Jeffrey Hubbell was born in 1959 in Kansas City, Missouri, and is a citizen of the United States of America. He obtained his Bachelor of Science degree in chemical engineering at Kansas State University in 1982 and his doctorate in chemical engineering at Rice University in 1986. He was assistant and associate professor of chemical engineering at the University of Texas, Austin, from 1986 - 1994, and professor of chemical engineering at the California Institute of Technology from 1995 - 1997. Jeffrey A. Hubbell has been full Professor of Biomedical Engineering and director of the Institute for Biomedical Engineering of the ETH and the University of Zurich, Professor of Materials Science since 1 June 1997 and an ETH professor of Material Science and an University professor at the Medical Faculty.

研究领域

Research in Prof. Hubbell's laboratory is directed toward biomaterials issues in tissue engineering, cell-based therapies, drug delivery, and medical devices. It involves polymer chemistry and cell biology ultimately directed toward altering some medical outcome. Current research addresses means by which the recognition of biological and synthetic polymers may be controlled, for example means by which to use polymers to block recognition in wound healing and immunity, by which to incorporate protein-like structures into synthetic materials, and by which to endow synthetic materials with the ability to be degraded by the cellular processes involved in tissue remodeling. Current clinical targets are cardiovascular implants and healing, nerve regeneration, post-surgical healing, and general aspects of the controlled delivery of proteins and genes.

近期论文

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J. L. Zakrzewski, M. R. M. Van Den Brink and J. A. Hubbell. Overcoming immunological barriers in regenerative medicine, in Nature Biotechnology, vol. 32, num. 8, p. 786-794, 2014. V. Manzoli, C. Villa, A. Pileggi, R. Molano and Y. Torrente et al. Conformal Coating of Islets of Langerhans: a Microfluidic Approach for Transplantation Without Immunosuppression. TERMIS-AM Conference, Washington, DC, 2014. O. F. Vila, M. M. Martino, L. Nebuloni, G. Kuhn and S. Perez-Amodio et al. Bioluminescent and micro-computed tomography imaging of bone repair induced by fibrin-binding growth factors, in Acta Biomaterialia, vol. 10, num. 10, p. 4377-4389, 2014. V. Sacchi, M. M. Martino, R. Gianni-Barrera, M. Heberer and J. A. Hubbell et al. Normalization and Accelerated Stabilization of VEGF-Induced Angiogenesis by Co-Delivery of Engineered PDGF-BB and VEGF Proteins From Fibrin Matrices. 17th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Washington, DC, 2014. L. Jeanbart, M. Ballester, A. De Titta, P. Corthesy and P. Romero et al. Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes, in Cancer Immunology Research, vol. 2, num. 5, p. 436-447, 2014. H. M. Larsson, F. Gorostidi, J. A. Hubbell, Y. Barrandon and P. Frey. Human and porcine urothelial stem cells. , 2014. V. Sacchi, M. M. Martino, R. Gianni-Barrera, J. A. Hubbell and A. Banfi. Normalization and accelerated stabilization of VEGF-induced angiogenesis by co-delivery of engineered PDGF-BB and VEGF proteins from fibrin matrices. , 2014. P. Briquez, F. Tortelli, M. Martino, M. Pisano and J. Hubbell. Extracellular matrix molecules regulate growth factor and cytokine delivery through their heparin-binding domains and promote wound healing. , 2014. E. Vardar, P. Frey and J. A. Hubbell. Engineered fibrin based scaffolds for urological tissue engineering applications. , 2014. M. Martino, P. Briquez, E. Guec, F. Tortelli and W. Kilarski et al. Growth factors engineered for super-affinity to extracellular matrix enhance tissue healing. , 2014. A. A. Tomei, V. Manzoli, C. A. Fraker, J. Giraldo and D. Velluto et al. Device design and materials optimization of conformal coating for islets of Langerhans, in Proceedings Of The National Academy Of Sciences Of The United States Of America, vol. 111, num. 29, p. 10514-10519, 2014. A. E. Vasdekis, E. A. Scott, C. P. O'Neil, D. Psaltis and J. A. Hubbell. Cytoplasmic Stopped Flow at the Single Cell Level Based on Photosensitive Polymersomes. [u'58th Annual Meeting of the Biophysical-Society', u'58th Annual Meeting of the Biophysical-Society'], 2014. A. de Titta, M. Swartz and J. A. Hubbell (Dirs.). Engineering adjuvants for prophylactic and therapeutic subunit vaccines. EPFL, Lausanne, 2014. V. Sacchi, R. Mittermayr, J. Hartinger, M. M. Martino and K. M. Lorentz et al. Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF(164), in Proceedings Of The National Academy Of Sciences Of The United States Of America, vol. 111, num. 19, p. 6952-6957, 2014. C.-Y. Lee, F. Teymour, H. Camastral, N. Tirelli and J. A. Hubbell et al. Characterization of the Network Structure of PEG Diacrylate Hydrogels Formed in the Presence of N-Vinyl Pyrrolidone, in Macromolecular Reaction Engineering, vol. 8, num. 4, p. 314-328, 2014. R. P. H. Meier, J. D. Seebach, P. Morel, R. Mahou and S. Borot et al. Survival of Free and Encapsulated Human and Rat Islet Xenografts Transplanted into the Mouse Bone Marrow, in Plos One, vol. 9, num. 3, 2014. H. M. Larsson, F. Gorostidi, J. A. Hubbell, Y. Barrandon and P. Frey. Clonal, Self-Renewing and Differentiating Human and Porcine Urothelial Cells, a Novel Stem Cell Population, in Plos One, vol. 9, num. 2, 2014. M. M. Martino, P. S. Briquez, E. Guc, F. Tortelli and W. W. Kilarski et al. Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing, in Science, vol. 343, num. 6173, p. 885-888, 2014. S. N. Thomas, E. Vokali, A. W. Lund, J. A. Hubbell and M. A. Swartz. Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response, in Biomaterials, vol. 35, num. 2, p. 814-824, 2014.