孙桂波 - 中国医学科学院药用植物研究所 -

研究领域

主要从事中药心脑血管药理学研究及中药复方的配伍机制研究。

近期论文

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1. Sun, G. B., Qin, M., Ye, J. X., Pan, R. L., Meng, X. B., Wang, M., Luo, Y., Li, Z. Y., Wang, H. W., and Sun, X. B. (2013) Inhibitory effects of myricitrin on oxidative stress-induced endothelial damage and early atherosclerosis in ApoE-/- mice, Toxicol Appl Pharmacol 271, 114-126. 2.Sun, G. B., Sun, X., Wang, M., Ye, J. X., Si, J. Y., Xu, H. B., Meng, X. B., Qin, M., Sun, J., Wang, H. W., and Sun, X. B. (2012) Oxidative stress suppression by luteolin-induced heme oxygenase-1 expression, Toxicol Appl Pharmacol 265, 229-240. 3.Sun GB, Sun H, Meng XB, Hu J, Zhang Q, Liu B, Wang M, Xu HB, Sun XB. Aconitine-induced ca overload causes arrhythmia and triggers apoptosis through p38 mapk signaling pathway in rats. Toxicol Appl Pharmacol. 2014, Aug 15; 279(1):8-22. 4.Wang, M., Sun, G. B*., Sun, X., Wang, H. W., Meng, X. B., Qin, M., Sun, J., Luo, Y., and Sun, Sun X. B*. (2013) Cardioprotective effect of salvianolic acid B against arsenic trioxide-induced injury in cardiac H9c2 cells via the PI3K/Akt signal pathway, Toxicol Lett 216, 100-107. 5.Wang, M., Sun, G*., Wu, P., Chen, R., Yao, F., Qin, M., Luo, Y., Sun, H., Zhang, Q., Dong, X., and Sun, X.* (2013) Salvianolic Acid B prevents arsenic trioxide-induced cardiotoxicity in vivo and enhances its anticancer activity in vitro, Evid Based Complement Alternat Med 2013, 759483. 6.Sun, J., Sun, G.*, Meng, X., Wang, H., Wang, M., Qin, M., Ma, B., Luo, Y., Yu, Y., Chen, R., Ai, Q., and Sun, X.* (2013) Ginsenoside RK3 Prevents Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes via AKT and MAPK Pathway, Evid Based Complement Alternat Med 2013, 690190. 7.Meng, X., Sun, G.,* Wang, M., Sun, J., Qin, M., and Sun, X*. P90RSK and Nrf2 Activation via MEK1/2-ERK1/2 Pathways Mediated by Notoginsenoside R2 to Prevent 6-Hydroxydopamine-Induced Apoptotic Death in SH-SY5Y Cells, Evid Based Complement Alternat Med 2013,971712. 8.Chen RC, Xu XD, Zhi Liu X, Sun GB, Zhu YD, Dong X, Wang J, Zhang HJ, Zhang Q, Sun XB. Total flavonoids from Clinopodium chinense(Benth.) O. Ktze protect against doxorubicin- induced cardiotoxicity in vitro and in vivo. Evidence-based complementary and alternative medicine. 2015:472565. 9.Yun Luo, Xi Dong, Yingli Yu, Guibo Sun, Xiaobo Sun.Total aralosides of Aralia elata (Miq) Seem (TASAES) ameliorate nonalcoholic steatohepatitis by modulating IRE1α-mediated JNK and NF-κB pathways in ApoE-/- mice. Journal of Ethnopharmacology. 2015 Apr 2;163:241-50. doi:10.1016/j.jep.2015.01.017. 10.Yun Luo, Guibo Sun, Xi Dong, Min Wang, Meng Qin, Yingli Yu, Xiaobo Sun.Isorhamnetin Attenuates Atherosclerosis by Inhibiting Macrophage Apoptosis via PI3K/AKT Activation and HO-1 Induction[J].PLOS ONE. 2015 Mar 23;10(3):e0120259. . 11.Chen RC, Wang J, Yu YL, Sun GB* and Sun XB*. Protective effect of total saponins of Aralia elata (Miq) Seem on lipopolysaccharide-induced cardiac dysfunction via down-regulation of inflammatory signaling in mice. RSC Adv., 2015, 5, 22560-22570. 12.R. chen, G. Sun, J. wang, H. zhang and X. sun, Naringin protects against anoxia/reoxygenation-induced apoptosis in H9c2 cells via the Nrf2 signaling pathway. Food Funct., 2015 Apr 8;6(4):1331-44. 13.Qidi Ai,Guibo Sun,Yun Luo,Xi Dong,Ruifeng Hu,a Xiangbao Meng and Xiaobo Sun. Ginsenoside Rb1 Prevents Hypoxia–Reoxygenation-Induced Apoptosis in H9c2 Cardiomyocytes via an Estrogen Receptor-Dependent Crosstalk among the Akt, JNK, and ERK 1/2 Pathways Using a Label-Free Quantitative Proteomics Analysis. RSC Advances, 2015, 5, 26346 – 26363. 14. Min Wang, Gui-bo Sun,Jing-yi Zhang, Yun Luo, Ying-li Yu, Xu-dong Xu, Xiang-bao Meng,Miao-di Zhang, Wen-bin Lin, Xiao-bo Sun. Elatoside C protects the heart from ischaemia/reperfusion injury through the modulation of oxidative stress and intracellular Ca2+ homeostasis. International Journal of Cardiology 185 (2015) 167–176. 15.Meng Qin; Yun Luo; Xiang-bao Meng; Min Wang; Hong-wei Wang; Shi-yu Song; Jingxue Ye; Rui-le Pan; Fan Yao; Ping Wu; Gui-bo Sun*; Xiao-bo Sun*. Myricitrin Attenuates Endothelial Cell Apoptosis to Prevent Atherosclerosis: An Insight into PI3K/Akt Activation and STAT3 Signaling Pathways. VASCULAR PHARMACOLOGY, 2015 Apr 4. pii: S1537- 1891(15)00035-X. doi: 10.1016/j.vph.2015.03.002.