齐云 - 中国医学科学院药用植物研究所 -

个人简介

1999年从成都中医药大学博士毕业后进入中国中医科学院中西医结合专业博士后流动站

研究领域

中药与植物药的抗炎免疫药理从整体、离体及细胞分子角度研究感染性炎症及I型过敏反应，重点聚焦于植物提取物及其有效组分或成分。抗炎上主要研究内毒素通过巨噬细胞TLR4通路的经典炎症反应的影响；在I型过敏反应方面，集中于对sIgE生成及肥大细胞脱颗粒细胞动物模型的建立及植物药活性的筛查，中药注射剂变态反应毒性及分子机制的研究。

近期论文

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1、Evaluation of the intestinal transport of phenylethanoid glycosides-rich extract from Cistanche deserticola across the Caco-2 cell monolayer model [J]. Plos one. 2015, 10(2): e011649. (IF: 3.534 ISSN: 1932-6203) 2.Shuang-Huang-Lian Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice Involving Anti-Inflammatory and Antioxidative Activities. Evid Based Complement Alternat Med, 2015, doi: 10.1155/2015/283939. (IF:2.175 ISSN: 1741-427X) 3.Rhein exerts pro- and anti-inflammatory actions by targeting IKKβ inhibition in LPS-activated macrophages　[J]. Free Radic Biol Med. 2014, 72: 104-112　(IF: 5.71 ISSN: 0891-5849) 4.Genkwanin inhibits proinflammatory mediators mainly through the regulation of miR-101/MKP-1/MAPK pathway in LPS-activated macrophages [J]. Plos one. 2014, 9(5): e96741. (IF: 3.534 ISSN: 1932-6203) 5.Suppressive effects of irisflorentin on LPS-induced inflammatory responses in RAW 264.7 macrophages [J]. Exp Biol Med. 2014, 16;239(8):1018-1024 (IF: 2.226 ISSN: 1535-3702) 6.Comparison of the endothelial toxicity induced by short-term amiodarone and diazepam exposure in a human umbilical vein endothelial cell line (EVC304) [J]. Pharm Biol. 2014, 52(10):1256-61. (IF: 1.337 ISSN: 1388-0209) 7.Shuang-Huang-Lian exerts anti-inflammatory and antioxidative activities in lipopolysaccharide stimulated murine alveolar macrophages [J]. Phytomedicine, 2014, 21: 461-469 (IF: 2.877 ISSN: 0944-7113) 8.Curcumol exhibits anti-inflammatory properties by interfering with the JNK-mediated AP-1 pathway in lipopolysaccharide-activated RAW264.7 cells [J]. Eur J Pharmacol, 2014, 723: 339-345 (IF: 2.684 ISSN: 0014-2999) 9.Preparation of highly specific anti-zearalenone antibodies by using the cationic protein conjugate and development of an indirect competitive enzyme-linked immunosorbentassay [J]. Analyst, 2012, 137, 229-236 (IF 3.969 ISSN: 0003-2654) 10.Pharmacological basis for the medicinal use of muskmelon base (Pedicellus Melo.) for abdominal distention and constipation [J].J Ethnopharmacol. 2012, 142:129-135. (IF 2.755 ISSN: 0378-8741 )　 11.Salvia miltiorrhiza lipid-soluble extract inhibits LPS-induced inflammatory mediators production via the NF-κB modulation in RAW 264.7 cells and performs anti-inflammatory effect in vivo [J]. Phytother. Res. 2012, 26: 1195-1204. (IF 2.068 ISSN: 0951-418X )　 12.Antihypertensive effect of total flavone extracts from PuerariaeRadix [J]. J Ethnopharmacol. 2011, 133:177–183 (IF: 3.014 ISSN: 0378-8741 )