个人简介
1984年毕业于西安医学院药学系获学士学位。1998-2002年期间于香港中文大学药剂学院攻读博士，并获理学博士学位，2002-2004年在香港中文大学理学院从事博士后研究，进行中药活性成分的肠吸收转运机制和体内药代动力学研究（ADME）。2004年回药用植物研究所，现任药理毒理中心副主任。
研究领域
1. 创新中药的临床前药代动力学（ADME）研究；
2. 运用药代动力学方法进行中药体内药效物质基础研究；
3. 中药药效成分的吸收转运机制研究；
4. 基于药物转运和代谢的药物相互作用研究.
近期论文
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1. Wang GN, Pan RL, Liao YH, Chen Y, Tang JT, Chang Q. An LC-MS/MS method for determination of forsythiaside in rat plasma and application to a pharmacokinetic study. J Chromatogr B 2010：878 (1):102-106.
2. Chen Y, Liu XM, Pan RL, Wang GN, Fu Y, Chang Q. An LC-MS/MS method for determination of 3,6'-disinapoylsucrose in rat plasma and its application to a pharmacokinetic study. Biomed Chromatogr. 2009, 23 (12):1326-1332.
3. Chang Q, Chow MS, Zuo Z. Studies on the influence of esterase inhibitor to the pharmacokinetic profiles of oseltamivir and oseltamivir carboxylate in rats using an improved LC/MS/MS method. Biomed Chromatogr. 2009; 23: 852–857.
4. Xi J, Chang Q, Chan CK, Meng ZY, Wang GN, Sun JB, Wang YT, Tong HH, Zheng Y. Formulation Development and Bioavailability Evaluation of a Self-Nanoemulsified Drug Delivery System of Oleanolic Acid. AAPS PharmSciTech. 2009;10 (1):172-182.
5. Ma KY, Zhang ZS, Zhao SX, Chang Q, Wong YM, Yeung SYV, Huang Y, Chen ZY. Red yeast rice increases excretion of bile acids in hamsters. Biomedical and environmental sciences, 2009, 22: 269-277.
6. Peng B, Chang Q, Wang L, Hu Q, Wang Y, Tang J, Liu X. Suppression of human ovarian SKOV-3 cancer cell growth by Duchesnea phenolic fraction is associated with cell cycle arrest and apoptosis. Gynecol Oncol. 2008, 108(1):173-181.
7. Chang Q, Sun L, Zhao RH, Chow MSS, Zuo Z: Simultaneous determination of ten active components in traditional Chinese medicinal products containing both Gegen (Pueraria lobata) and Danshen (Salvia miltiorrhiza) by high performance liquid chromatography. Phytochemical analysis. 2008, 19(4):368-375.
8. Chang Q, Zuo Z, Ho WKK and Chow M Effect of storage temperature on phenolics stability in hawthorn fruits and a hawthorn drink. Food Chemistry 2006, 98: 423-430.
9. Chang Q, Zuo Z, Ho WKK and Chow M: Difference in absorption and bioavailability of the two structurally similar flavonoid glycosides, hyperoside and isoquercitrin, in rats. European Journal of Pharmaceutics and Biopharmaceutics 2005, 59:549-555.
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