韩晓男 - 中国医学科学院医学实验动物研究所 -

个人简介

2000年毕业于中国医学科学院和中国协和医科大学病理系，获病理学博士学位。先后在美国匹茨堡医学院重症医学，病理和分子细胞生物学中心以及美国辛辛那提儿童医院消化中心留学和工作。2016年被中国医学科学院医学实验动物研究所聘为教授。

研究领域

1. 建立慢性肠道感染、炎症和肠癌转基因工程小鼠模型和人诱导多能干细胞（iPSCs）模型，2. 细胞生长因子-转录激活信号（JAK2-STAT5）在调节肠道干细胞损伤和修复中的作用，3. 肠干细胞微环境与克隆氏病(Crohn’s diseases, CD) 和结肠癌（Colorectal Cancer， CRC）发病的关系，4. 利用人诱导多能干细胞（iPSCs）再建肠道屏障。

近期论文

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1. Nivarthi H, Gordziel C, Kramer N, Themanns M, Eberl M, Rabe B, Schlederer M, Knösel T, Kenner L, Freund P, Aberger F, Han X, Kralovics R, Dolznig H, Jennek S, Friedrich K, Moriggl R. The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth. Oncotarget, 2016 May 12. doi: 10.18632/oncotarget.9315. 2. Hainzl E, Stackingger S, Rauch I, Hieder S, Berry D, Lassnig C, Schwab C, Rosebock F, MilinovichG, schlederer M, Wagner, M, Schleper C, Loy, A, Urich T, Kenner L, Han X, Decker T, Strobl B,Muller M. Intestinal epithelial cell tyrosinekinase 2 transduces interleukin-22 signals to protect from acute colitis. J Immunol. 2015 Oct 2. pii: 1402565. 3. Han SS, Zhang R, Jain R, Shi H, Zhang L, Zhou G, Sangwung P, Tugal D, Atkins GB, Prosdocimo DA, Lu Y, Han X, Tso P, Liao X, Epstein JA, Jain MK. Circadian control of bile acid synthesis by a KLF15-Fgf15 axis. Nat Commun. 2015 Jun 4;6:7231. 4. Gilbert S1, Nivarthi H1, Mayhew CN1, Lo YH, Noah TK, Vallance J, Rülicke T, Müller M, Jegga AG, Tang W, Zhang D, Helmrath M, Shroyer N, Moriggl R, Han X*. Activated STAT5 confers resistance to intestinal injury by increasing intestinal stem cell proliferation and regeneration. Stem Cell Reports. 2015 Feb 10;4(2):209-25. 5. Zhang R1, Gilbert S1, Yao X1, Vallance J, Steinbrecher K, Moriggl R, Eluri M, Shroyer N, Cao H, Denson L, Han X*. Methyl Protodiosin Protests against Mucosal Injury by Promoting Commensal-induced Epithelial Innate Immunity. Pharmacology Research & Perspectives, 2015 2015 Mar;3(2):e00118. 6. Yang F, Zhou L, Wang Q, You X, Li Y, Zhao Y, Han X, Chang Z, He X, Cheng C, Wu C, Wang WJ, Hu FY, Zhao T, Li Y, Zhao M, Zheng GY, Dong J, Fan C, Yang J, Meng X, Zhang Y, Zhu X, Xiong J, Tian XL, Cao H. NEXN inhibits GATA4 and leads to atrial septal defects in mice and humans. Cardiovasc Res. 2014, 103(2):228-37. 7. Melendez J, Liu M, Sampson L, Akunuru S, Han X, Vallance J, Witte D, Shroyer N, Zheng Y. Cdc42 coordinates proliferation, polarity, migration, and differentiation of small intestinal epithelial cells in mice. Gastroenterology. 2013 Oct;145(4):808-19. 8. Gilbert S, Zhang R, Denson L, Moriggl R, Steinbrecher K, Shroyer N, Lin J, Han X*. Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation. EMBO Mol Med. 2012 Feb;4(2):109-24. 9. Han X*, Mann E, Gilbert S, Guan Y, Steinbrecher KA, Montrose MH, Cohen MB. Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier. PLoS One. 2011 Jan 31;6(1):e16139. 10. Han X*, Gilbert S, Groschwitz K, Hogan S, Jurickova I, Trapnell B, Samson C, Gully J. Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury. Gut. 2010 Aug;59(8):1066-78. 11. Munitz A, Cole ET, Waddell A, Groschwitz K, Ahrens R, Steinbrecher K, Willson T, Han X, Denson L, Rothenberg ME, Hogan SP. Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis. Gastroenterology. 2010 Aug;139(2):530-41. 12. Han X, Uchida K, Jurickova I, Koch D, Willson T, Samson C, Bonkowski E, Trauernicht A, Kim MO, Tomer G, Dubinsky M, Plevy S, Kugathsan S, Trapnell BC, Denson LA. Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease. Gastroenterology. 2009 Apr;136(4):1261-71, e1-3. 13. Han X*, Ren X, Jurickova I, Groschwitz K, Pasternak BA, Xu H, Wilson TA, Hogan SP, Denson LA*. Regulation of intestinal barrier function by signal transducer and activator of transcription 5b. Gut. 2009 Jan;58(1):49-58. 14. Groschwitz KR, Ahrens R, Osterfeld H, Gurish MF, Han X, Abrink M, Finkelman FD, Pejler G, Hogan SP. Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22381-6. 15. Han X, Osuntokun B, Benight N, Loesch K, Frank S, Denson L. Signal transducer and activator of transcription 5b (STAT5b) promotes mucosal tolerance in pediatric Crohn’s disease and murine colitis. Am J Pathol. 2006;169(6):1999-2013. 16. Han X, Benight N, Osuntokun B, Loesch K, Frank SJ, Denson LA. Tumour necrosis factor alpha blockade induces an anti-inflammatory growth hormone signalling pathway in experimental colitis. Gut. 2007 Jan;56(1):73-81. 17. Han X, Sosnowska D, Bonkowski EL, Denson LA. Growth hormone inhibits signal transducer and activator of transcription 3 activation and reduces disease activity in murine colitis. Gastroenterology. 2005 Jul;129(1):185-203.