研究领域
利用动物模型，开展重大免疫性疾病的发病机制研究。
1. 免疫系统与心血管系统的对话机制：侧重于自身免疫性心血管病的发病机制研究
2. 疾病发生过程中免疫系统与肠道微生物菌群的相互协调拮抗的机制：探讨微生物菌群、细胞因子、免疫细胞之间的协调对话机制及对重大免疫性疾病发病的影响。
3. 胆固醇及脂类代谢与免疫系统的关系：探讨胆固醇及脂类代谢在免疫细胞信号传导中的调节机制。
4. 寻找并开发相关炎性因子抑制剂，早期诊断生物标记物等。
近期论文
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1. Applications of Next-generation Sequencing in Systemic Autoimmune Diseases. Genomics Proteomics Bioinformatics 13 (2015) 242–249
2. Intestinal Microbiota Metabolism and Atherosclerosis. Chinese Medicine Journal.(English). 2015 20th Oct;128(20):2805-2811
3. Activation of rheumatoid factor-specific B cells is antigen dependent and occurs preferentially outside of germinal centers in the lupus-prone NZM2410 mouse model. Journal of Immunology. 2014 Aug 15;193(4):1609-21
4. The function of hematopoietic stem cells is altered by both genetic and inflammatory factors in lupus mice. Blood. 2013 Mar 14;121(11):1986-94
5. Female mouse fetal loss mediated by maternal autoantibody. Journal of Experimental Medicine, 2012 Jun 4;209(6):1083-9
6. Murine lupus susceptibility locus Sle2 activates DNA-reactive B cells through two sub-loci with distinct phenotypes. Genes & Immunity, 2011 Apr;12(3):199-207
7. Autoreactive marginal zone B cells enter the follicles and interact with CD4+ T cells in lupus-prone mice. BMC immunology, 2011 Jan 20;12:7
学术兼职
2010-至今Molecular Medicine 杂志 (影响因子4.8) 副主编
2013-至今Bioelectronic Medicine副主编
2011-至今Clinical Immunology杂志 (影响因子3.7)编委
2010-Immunity, Blood，Journal of Autoimmunity等杂志审稿专家
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