Helm, Lothar - École polytechnique fédérale de Lausanne EPFL - Institute of Chemical Sciences and Engineering

个人简介

Lothar Helm was born in Germany in 1952. He studied physics at the University of Karlsruhe and got his diploma in 1977 in physical Chemistry and Electrochemistry. In 1980 he obtained his Ph.D. with a thesis on the interaction between ions in aqueous solution studied by nuclear magnetic relaxation, carried out under the supervision of Prof. H. G. Hertz. In 1980 he joined the Institute of Inorganic Chemistry at the University of Lausanne as post-doc. From 1982 to 1983 he was maître-assistant at the same institute. In 1983 he was appointed permanent researcher. Besides his research he became responsible technician for the NMR spectrometers of the institute and for the development of high-pressure NMR equipment. In 1999 he was appointed Privat Docent at the Faculty of Science of the University of Lausanne. Together with the whole chemistry department he moved 2001 to the EPFL. Since 2006 he is titular professor and director of the NMR service of the Institute of Chemical Sciences and Engineering.

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Dynamic aggregation of the mid-sized gadolinium complex {Ph-4[Gd(DTTA)(H2O)(2)](-)(3)}. H. Jaccard, P. Mieville, C. Cannizzo, C. R. Mayer and L. Helm. in Journal of Biological Inorganic Chemistry, vol. 19, num. 2, p. 145-159, 2014. Speciation of aqueous tellurium(IV) in hydrothermal solutions and vapors, and the role of oxidized tellurium species in Te transport and gold deposition. P. V. Grundler, J. Brugger, B. E. Etschmann, L. Helm, W. Liu, P. G. Spry, Y. Tian, D. Testemale and A. Pring. in Geochimica Et Cosmochimica Acta, vol. 120, p. 298-325, 2013. H-1 and O-17 NMR Relaxometric and Computational Study on Macrocyclic Mn(II) Complexes. G. A. Rolla, C. Platas-Iglesias, M. Botta, L. Tei and L. Helm. in Inorganic Chemistry, vol. 52, num. 6, p. 3268-3279, 2013. Gadolinium complexes of monophosphinic acid DOTA derivatives conjugated to cyclodextrin scaffolds: efficient MRI contrast agents for higher magnetic fields. Z. Kotkova, L. Helm, J. Kotek, P. Hermann and I. Lukes. in Dalton Transactions, vol. 41, num. 43, p. 13509-13519, 2012. NMR and Electron Paramagnetic Resonance Studies of [Gd(CH3CN)(9)](3+) and [Eu(CH3CN)(9)](2+): Solvation and Solvent Exchange Dynamics in Anhydrous Acetonitrile. G. Bodizs and L. Helm. in Inorganic Chemistry, vol. 51, p. 5881-5888, 2012. New Bisaqua Picolinate-Based Gadolinium Complexes as MRI Contrast Agents with Substantial High-Field Relaxivities. A. M. Nonat, C. Gateau, P. H. Fries, L. Helm and M. Mazzanti. in European Journal Of Inorganic Chemistry, p. 2049-2061, 2012. Serum Albumin Targeted, pH-Dependent Magnetic Resonance Relaxation Agents. L. Moriggi, M. A. Yaseen, L. Helm and P. Caravan. in Chemistry-A European Journal, vol. 18, p. 3675-3686, 2012. Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chelates as high relaxivity contrast agents for MRI. M. F. Ferreira, B. Mousavi, P. M. Ferreira, C. I. O. Martins, L. Helm, J. A. Martins and C. F. G. C. Geraldes. in Dalton Transactions, vol. 41, p. 5472-5475, 2012. Isoquinoline-Based Lanthanide Complexes: Bright NIR Optical Probes and Efficient MRI Agents. F. Caillé, C. S. Bonnet, F. Buron, S. Villette, L. Helm, S. Petoud, F. Suzenet and É. Tóth. in Inorganic Chemistry, vol. 51, num. 4, p. 2522-2532, 2012. Pyridine-Based Lanthanide Complexes Combining MRI and NIR Luminescence Activities. C. S. Bonnet, F. Buron, F. Caille, C. M. Shade, B. Drahos, L. Pellegatti, J. Zhang, S. Villette, L. Helm, C. Pichon, F. Suzenet, S. Petoud and E. Toth. in Chemistry-A European Journal, vol. 18, p. 1419-1431, 2012. O-17 NMR and Density Functional Theory Study of the Dynamics of the Carboxylate Groups in DOTA Complexes of Lanthanides in Aqueous Solution. F. Mayer, C. Platas-Iglesias, L. Helm, J. A. Peters and K. Djanashvili. in Inorganic Chemistry, vol. 51, p. 170-178, 2012. Electronic fine structure calculation of [Gd(DOTA)(H2O)]- using LF-DFT: The zero field splitting. F. Senn, L. Helm, A. Borel and C. A. Daul. in Comptes Rendus Chimie, vol. 15, num. 2-3, p. 250-254, 2012. Mn2+ Complexes with 12-Membered Pyridine Based Macrocycles Bearing Carboxylate or Phosphonate Pendant Arm: Crystallographic, Thermodynamic, Kinetic, Redox, and 1H/17O Relaxation Studies. B. Drahoš, J. Kotek, I. Cı́Sařová, P. Hermann, L. Helm, I. Lukeš and É. Tóth. in Inorganic Chemistry, vol. 50, num. 24, p. 12785-12801, 2011. NMR Study of Ligand Exchange and Electron Self-Exchange between Oxo-Centered Trinuclear Clusters [Fe3(μ3-O)(μ-O2CR)6(4-R´py)3]+/0. G. Novitchi, L. Helm, C. Anson, A. K. Powell and A. Merbach. in Inorganic Chemistry -American Chemical Society-, vol. 50, num. 20, p. 10402-10416, 2011. Synthesis, complexation and NMR relaxation properties of Gd3+ complexes of Mes(DO3A)3. P. Miéville, H. Jaccard, F. Reviriego, R. Tripier and L. Helm. in Dalton Transactions, num. 40, p. 4260-4267, 2011. NMR of Insensitive Nuclei Enhanced by Dynamic Nuclear Polarization. P. Miéville, S. Jannin, L. Helm and G. Bodenhausen. in CHIMIA International Journal for Chemistry, vol. 65, num. 4, p. 260-263, 2011. Isomerization Mechanisms of Stereolabile tris- and bis-Bidentate Octahedral Cobalt(II) Complexes: X-ray Structure and Variable Temperature and Pressure NMR Kinetic Investigation. F. Riblet, G. Novitchi, R. Scopelliti, L. Helm, A. Gulea and A. Merbach. in Inorganic Chemistry -American Chemical Society-, vol. 4, p. 414-4211, 2010. Geometrical confinement of gadolinium-based contrast agents in nanoporous particles enhances T1 contrast. J. S. Ananta, B. Godin, R. Sethi, L. Moriggi, X. Liu, R. E. Serda, R. Krishnamurthy, R. Muthupillai, R. D. Bolskar, L. Helm, M. Ferrari, L. J. Wilson and P. Decuzzi. in Nature Nanotechnology, vol. 203, p. doi:10.1038/nnano.2010.203, 2010. Kinetics of Yttrium-Ligand Complexation Monitored Using Hyperpolarized 89Y as a Model for Gadolinium in Contrast Agents. P. Miéville, S. Jannin, L. Helm and G. Bodenhausen. in Journal of the American Chemical Society, vol. 132, num. 14, p. 5006-5007, 2010.