Heinis, Christian - École polytechnique fédérale de Lausanne EPFL - Institute of Chemical Sciences and Engineering

个人简介

The main goal of Christian Heinis’ research is the development of therapeutics based on cyclic peptides. Towards this end, his laboratory is developing methods for synthesizing and screening large combinatorial libraries of cyclic peptides. Christian Heinis has studied biochemistry/chemistry at the ETH Zurich. After a PhD in the research group of Prof. Dr. Dario Neri at ETH, he did two post-docs, the first one with Prof. Dr. Kai Johnsson at the EPFL and the second one with Sir Gregory Winter at the LMB-MRC in Cambridge, UK. In 2008 he started as Assistant Professor at EPFL (supported with an SNSF professorship) and was promoted in 2015 to Associate Professor. Christian is a co-founder of Bicycle Therapeutics (BCYC) and the co-director of the NCCR Chemical Biology.

研究领域

Development of drugs based on cyclic peptides Phage display selection of bicyclic peptides High-throughput screening of macrocycles

近期论文

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Cyclative Release Strategy to Obtain Pure Cyclic Peptides Directly from the Solid Phase S. Habeshian; G. A. Sable; M. Schuettel; M. L. Merz; C. Heinis Acs Chemical Biology. 2022-01-11. DOI : 10.1021/acschembio.1c00843. Combining biological and chemical diversity C. Heinis Nature Chemistry. 2021-06-01. Vol. 13, num. 6, p. 512-513. DOI : 10.1038/s41557-021-00722-1. Chemical Biology and Drug Discovery Symposium at the LS2 Annual Meeting 2021 C. Heinis; A. Calvente Chimia. 2021-04-01. Vol. 75, num. 4, p. 342-342. DOI : 10.2533/chimia.2021.342. Cys-Cys and Cys-Lys Stapling of Unprotected Peptides Enabled by Hypervalent Iodine Reagents J. Ceballos; E. Grinhagena; G. Sangouard; C. Heinis; J. Waser Angewandte Chemie-International Edition. 2021-01-15. Vol. 60, num. 16, p. 9022-9031. DOI : 10.1002/anie.202014511. Generation of a Large Peptide Phage Display Library by Self-Ligation of Whole-Plasmid PCR Product X-D. Kong; V. Carle; C. Díaz-Perlas; K. Butler; C. Heinis ACS Chemical Biology. 2020-10-30. Vol. 15, num. 11, p. 2907-2915. DOI : 10.1021/acschembio.0c00497. A releasable disulfide-linked peptide tag facilitates the synthesis and purification of short peptides Y. Wu; A. Zorzi; J. Williams; C. Heinis Chemical Communications. 2020-03-07. Vol. 56, num. 19, p. 2917-2920. DOI : 10.1039/c9cc09247a. Synthesis of DNA‐encoded disulfide‐ and thioether‐cyclized peptides M. V. Pham; M. Bergeron‐Brlek; C. Heinis ChemBioChem. 2020. Vol. 21, num. 4, p. 543-549. DOI : 10.1002/cbic.201900390. The Partnership of DMCCB and LS2 C. von Schoultz; C. Heinis; Y. Auberson Chimia. 2018-11-01. Vol. 72, num. 11, p. 817-818. DOI : 10.2533/chimia.2018.817. Drugs Based on de novo-developed Peptides are Coming of Age K. Deyle; C. Heinis Chimia. 2018-06-01. Vol. 72, num. 6, p. 426-427. DOI : 10.2533/chimia.2018.426. Bypassing bacterial infection in phage display by sequencing DNA released from phage particles C. Villequey; X-D. Kong; C. Heinis Protein Engineering, Design and Selection. 2017-11-29. Vol. 30, num. 11, p. 761-768. DOI : 10.1093/protein/gzx057. Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides A. Zorzi; S. J. Middendorp; J. Wilbs; K. Deyle; C. Heinis Nature Communications. 2017. Vol. 8, p. 16092. DOI : 10.1038/ncomms16092. Precisely Regulated and Efficient Locking of Linear Peptides into Stable Multicyclic Topologies through a One-Pot Reaction W. Liu; Y. Zheng; X. Kong; C. Heinis; Y. Zhao et al. Angewandte Chemie-International Edition. 2017. Vol. 56, num. 16, p. 4458-4463. DOI : 10.1002/anie.201610942. Improving the binding affinity of in-vitro-evolved cyclic peptides by inserting atoms into the macrocycle backbone J. Wilbs; S. J. Middendorp; C. Heinis Chembiochem. 2016. Vol. 17, num. 24, p. 2299-2303. DOI : 10.1002/cbic.201600336. Phage Selection of Bicyclic Peptide Ligands of the Notch1 Receptor C. Urech-Varenne; F. Radtke; C. Heinis Chemmedchem. 2015. Vol. 10, num. 10, p. 1754-1761. DOI : 10.1002/cmdc.201500261. Identification of target-binding peptide motifs by high-throughput sequencing of phage-selected peptides I. R. Rebollo; M. Sabisz; V. Baeriswyl; C. Heinis Nucleic Acids Research. 2014. Vol. 42, num. 22, p. e169. DOI : 10.1093/nar/gku940. Chemical biology & drug discovery L. H. Jones; C. Heinis European Journal Of Medicinal Chemistry. 2014. Vol. 88, p. 1-2. DOI : 10.1016/j.ejmech.2014.10.017. Phage selection of bicyclic peptides binding Her2 P. Diderich; C. Heinis Tetrahedron. 2014. Vol. 70, num. 42, p. 7733-7739. DOI : 10.1016/j.tet.2014.05.106. Drug discovery: tools and rules for macrocycles C. Heinis Nature chemical biology. 2014. Vol. 10, num. 9, p. 696-8. DOI : 10.1038/nchembio.1605. Phage Selection of Photoswitchable Peptide Ligands S. Bellotto; S. Chen; I. R. Rebollo; H. A. Wegner; C. Heinis Journal Of The American Chemical Society. 2014. Vol. 136, num. 16, p. 5880-5883. DOI : 10.1021/ja501861m.